Study of the Performance of the KeyPath MRSA/MSSA Blood Culture Test - BTA

NCT ID: NCT01640886

Last Updated: 2013-01-15

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

TERMINATED

Total Enrollment

764 participants

Study Classification

OBSERVATIONAL

Study Start Date

2012-06-30

Study Completion Date

2012-12-31

Brief Summary

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In vitro identification of S. aureus,methicillin-sensitive S. aureus (MSSA) and methicillin-resistant S. aureus (MRSA)from positive blood culture using MicroPhage's bacteriophage-based diagnostic platform.

Detailed Description

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This is a multi-center clinical study to investigate the effectiveness of the performance of the KeyPath MRSA/MSSA Blood Culture Test - BTA. The KeyPath test is performed directly on positive blood culture specimens from bioMerieux BacT/ALERT blood culture bottles. The MicroPhage test will be compared to standards and market available tests with similar indications (comparators). It is estimated that the study will last 3-4 months depending on the accural rate at the institutions.

Conditions

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Bacteremia

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

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Standard of Care

1. Comparison of S. aureus to the reference methods for S. aureus (tube coagulase and Staphaurex.)
2. Comparison to the reference method (30 ug cefoxitin disc diffusion).

No interventions assigned to this group

KeyPath Test Group

All specimens collected that meet the inclusion criteria will be tested using the KeyPath BTA Test.

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

1. Blood culture samples determined to be Gram-positive from subjects aged 18+, inclusive, with any of the following bottle types:

* bioMerieux BacT/ALERT® Standard Aerobic and Anaerobic
* bioMerieux BacT/ALERT® FAN Aerobic and FAN Anaerobic
2. Completion of the KeyPathTM BTA Test on the sample.
3. Completion of the reference method for S. aureus identification (tube coagulase and Remel Staphaurex ) and completion of the reference method for methicillin resistance determination (30 µg cefoxitin disc diffusion) for S. aureus positive samples.

Exclusion Criteria

1. Samples from blood culture positives over 24 hours from alarm
2. Samples deemed contaminated.
3. Violations and/or deviations from the KeyPathTM BTA Test protocol and/or other included test protocols under study.
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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MicroPhage, Inc.

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Dipankar Manna, Ph.D.

Role: PRINCIPAL_INVESTIGATOR

MicroPhage, Inc.

Locations

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University of Arizona, Infectious Disease Research

Tuscon, Arizona, United States

Site Status

UCLA Clinical Laboratory

Los Angeles, California, United States

Site Status

Medical University of South Carolina

Charleston, South Carolina, United States

Site Status

Countries

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United States

Other Identifiers

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MP2012-A

Identifier Type: -

Identifier Source: org_study_id

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