Clinical AML Registry and Biomaterial Database of the Study Alliance Leukemia (SAL)
NCT ID: NCT03188874
Last Updated: 2024-04-18
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
15000 participants
OBSERVATIONAL
2010-09-30
2030-09-30
Brief Summary
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Investigator's sites: 51 sites in Germany.
Primary objectives:
* Identification of epidemiological data on AML: age, prognostic factors and subgroup distributions. Incidence and age distribution are compared with the data of population-related tumor registry.
* Evaluation of the most important patient-relevant clinical endpoints (outcomes): relapse-free survival (RFS) / time to relapse (TTR), calculation of cumulative incidence of relapse (CIR) and overall survival (OS)
* Documentation of treatment strategy
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Detailed Description
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Conditions
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Study Design
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CASE_ONLY
PROSPECTIVE
Eligibility Criteria
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Inclusion Criteria
* Age ≥ 18 years. There is no upper age limit.
* Signed written informed consent
18 Years
ALL
No
Sponsors
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Technische Universität Dresden
OTHER
Responsible Party
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Principal Investigators
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Christoph Röllig, Prof. Dr.
Role: STUDY_DIRECTOR
Universitätsklinikum Carl Gustav Carus
Locations
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Klinikum Mittelbaden
Baden-Baden, Baden-Wurttemberg, Germany
Universtitätsklinikum Heidelberg
Heidelberg, Baden-Wurttemberg, Germany
Klinikum Mannheim GmbH
Mannheim, Baden-Wurttemberg, Germany
Diakonie-Klinikum
Schwäbisch Hall, Baden-Wurttemberg, Germany
Kliniken Sindelfingen-Böblingen gGmbH
Sindelfingen, Baden-Wurttemberg, Germany
Robert-Bosch-Krankenhaus GmbH
Stuttgart, Baden-Wurttemberg, Germany
Rems-Murr-Klinikum Winnenden
Winnenden, Baden-Wurttemberg, Germany
Klinikum Augsburg
Augsburg, Bavaria, Germany
Sozialstiftung Bamberg
Bamberg, Bavaria, Germany
Klinikum Bayreuth GmbH
Bayreuth, Bavaria, Germany
MVZ Klinikum Coburg GmbH
Coburg, Bavaria, Germany
Universitätsklinikum Erlangen
Erlangen, Bavaria, Germany
Klinikum Nürnberg
Nuremberg, Bavaria, Germany
Universitätsklinikum Würzburg
Würzburg, Bavaria, Germany
Carl-Thiem-Klinikum Cottbus gGmbH
Cottbus, Brandenburg, Germany
Klinikum Frankfurt (Oder) GmbH
Frankfurt (Oder), Brandenburg, Germany
Universitätsklinikum Frankfurt
Frankfurt am Main, Hesse, Germany
Klinikum Fulda / MVZ Osthessen GmbH
Fulda, Hesse, Germany
Universitätsklinikum Gießen und Marburg
Marburg, Hesse, Germany
Dr. Horst Schmidt Kliniken GmbH
Wiesbaden, Hesse, Germany
St. Bernward Krankenhaus Hildesheim
Hildesheim, Lower Saxony, Germany
Agaplesion Diakonieklinikum Rotenburg
Rotenburg (Wümme), Lower Saxony, Germany
Diakonie Klinikum Dietrich Bonhoeffer
Neubrandenburg, Mecklenburg-Vorpommern, Germany
Klinikum Südstadt Rostock
Rostock, Mecklenburg-Vorpommern, Germany
Marien Kliniken, St. Marien-Krankenhaus
Siegen, Nordhein-Westfalen, Germany
Universitätsklinikum Aachen
Aachen, North Rhine-Westphalia, Germany
Städt. Kliniken Bielefeld gem. GmbH - Klinikum Mitte
Bielefeld, North Rhine-Westphalia, Germany
Augusta Kranken Anstalt Bochum
Bochum, North Rhine-Westphalia, Germany
Helios Klinikum Duisburg
Duisburg, North Rhine-Westphalia, Germany
Krankenhaus Düren gGmbH
Düren, North Rhine-Westphalia, Germany
Universitätsklinikum Düsseldorf
Düsseldorf, North Rhine-Westphalia, Germany
Universitätsklinikum Essen
Essen, North Rhine-Westphalia, Germany
Klinikum Gütersloh
Gütersloh, North Rhine-Westphalia, Germany
St. Barbara-Klinik Hamm GmbH
Hamm, North Rhine-Westphalia, Germany
Universitätsklinikum Münster
Münster, North Rhine-Westphalia, Germany
Diakonie Klinikum GmbH Jung-Stilling-Krankenhaus
Siegen, North Rhine-Westphalia, Germany
Stiftungsklinikum Mittelrhein GmbH
Koblenz, Rhineland-Palatinate, Germany
Klinikum Chemnitz gGmbH
Chemnitz, Saxony, Germany
Universitätsklinikum Carl Gustav Carus
Dresden, Saxony, Germany
Universitätsklinikum Leipzig
Leipzig, Saxony, Germany
Klinikum St. Georg gGmbH
Leipzig, Saxony, Germany
Elblandkliniken Stiftung & Co.KG
Riesa, Saxony, Germany
Krankenhaus Martha-Maria Halle-Dölau
Halle, Saxony-Anhalt, Germany
Universitätsklinikum Halle (Saale)
Halle, Saxony-Anhalt, Germany
Johanniter-Krankenhaus Genthin-Stendal
Stendal, Saxony-Anhalt, Germany
Universitätsklinikum Schleswig-Holstein
Kiel, Schleswig-Holstein, Germany
Städtisches Krankenhaus Kiel GmbH
Kiel, Schleswig-Holstein, Germany
Klinikum Altenburger Land GmbH
Altenburg, Thuringia, Germany
Universitätsklinikum Jena
Jena, Thuringia, Germany
Helios Klinikum Berlin-Buch
Berlin, , Germany
Ev. Diakonie-Krankenhaus gemeinn. GmbH Bremen
Bremen, , Germany
Countries
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Central Contacts
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Facility Contacts
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Kai Neben, Prof.
Role: primary
Carsten Müller-Tidow, Prof.
Role: primary
Stefan Klein, PD Dr.
Role: primary
Thomas Geer, Dr.
Role: primary
Markus Ritter, PD Dr.
Role: primary
Martin Kaufmann, Dr.
Role: primary
Markus Schaich, Prof.
Role: primary
Andreas Rank, PD Dr.
Role: primary
Ruth Seggewiß-Bernhard, PD Dr.
Role: primary
Alexander Kiani, Prof.
Role: primary
Christof Lamberti, PD. Dr.
Role: primary
Stefan Krause, Prof.
Role: primary
Kerstin Schäfer-Eckart, Dr.
Role: primary
Hermann Einsele, Prof.
Role: primary
Martin Schmidt-Hieber, PD Dr.
Role: primary
Michael Kiehl, Prof.
Role: primary
Hubert Serve, Prof.
Role: primary
Heinz-Gert Höffkes, Prof.
Role: primary
Andreas Neubauer, Prof.
Role: primary
Natalia Heinz, Dr.
Role: primary
Ulrich Kaiser, Prof.
Role: primary
Achim Meinhardt, Dr.
Role: primary
Philipp Hemmati, PD Dr.
Role: primary
Beate Krammer-Steiner, Dr.
Role: primary
Winfried Gassmann, Prof. Dr.
Role: primary
Tim H. Brümmendorf, Prof.
Role: primary
Martin Görner, PD Dr.
Role: primary
Dirk Behringer, Prof.
Role: primary
Götz Ulrich Grigoleit, PD Dr.
Role: primary
Michael Flaßhove, PD Dr.
Role: primary
Paul Jäger, Dr.
Role: primary
Maher Hanoun, Dr.
Role: primary
Gero Massenkeil, Prof.
Role: primary
Heinz Dürk, Dr.
Role: primary
Wolfgang Berdel, Prof.
Role: primary
Ralph Naumann, Prof. Dr.
Role: primary
Martin Klump, Dr.
Role: backup
Dirk Niemann, Dr.
Role: primary
Mathias Hänel, PD Dr.
Role: primary
Christoph Röllig, Prof.
Role: primary
Madlen Jentzsch, PD Dr.
Role: primary
Luisa Mantovani-Löffler, Dr.
Role: primary
Jörg Schubert, Prof.
Role: primary
Wolfgang Schütte, Prof.
Role: primary
Lutz Peter Müller, Prof.
Role: primary
Martin Mohren, PD Dr.
Role: primary
Claudia Baldus, Prof.
Role: primary
Roland Repp, Prof.
Role: primary
Romy Pomper, Dr.
Role: primary
Andreas Hochhaus, Prof.
Role: primary
Bertram Glaß, Prof.
Role: primary
Ulrich Trappe, Prof. Dr.
Role: primary
References
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Hanoun M, Ruhnke L, Kramer M, Hanoun C, Schafer-Eckart K, Steffen B, Sauer T, Krause SW, Schliemann C, Mikesch JH, Kaufmann M, Hanel M, Jost E, Brummendorf TH, Fransecky L, Kraus S, Einsele H, Niemann D, Neubauer A, Kullmer J, Seggewiss-Bernhard R, Gorner M, Held G, Kaiser U, Scholl S, Hochhaus A, Reinhardt HC, Platzbecker U, Baldus CD, Muller-Tidow C, Bornhauser M, Serve H, Rollig C; Study Alliance Leukemia (SAL). Intensified cytarabine dose during consolidation in adult AML patients under 65 years is not associated with survival benefit: real-world data from the German SAL-AML registry. J Cancer Res Clin Oncol. 2023 Jul;149(8):4611-4621. doi: 10.1007/s00432-022-04356-9. Epub 2022 Sep 28.
Kunadt D, Stasik S, Metzeler KH, Rollig C, Schliemann C, Greif PA, Spiekermann K, Rothenberg-Thurley M, Krug U, Braess J, Kramer A, Hochhaus A, Scholl S, Hilgendorf I, Brummendorf TH, Jost E, Steffen B, Bug G, Einsele H, Gorlich D, Sauerland C, Schafer-Eckart K, Krause SW, Hanel M, Hanoun M, Kaufmann M, Wormann B, Kramer M, Sockel K, Egger-Heidrich K, Herold T, Ehninger G, Burchert A, Platzbecker U, Berdel WE, Muller-Tidow C, Hiddemann W, Serve H, Stelljes M, Baldus CD, Neubauer A, Schetelig J, Thiede C, Bornhauser M, Middeke JM, Stolzel F; A. M. L. Cooperative Group (AMLCG), Study Alliance Leukemia (SAL). Impact of IDH1 and IDH2 mutational subgroups in AML patients after allogeneic stem cell transplantation. J Hematol Oncol. 2022 Sep 5;15(1):126. doi: 10.1186/s13045-022-01339-8.
Rollig C, Kramer M, Schliemann C, Mikesch JH, Steffen B, Kramer A, Noppeney R, Schafer-Eckart K, Krause SW, Hanel M, Herbst R, Kunzmann V, Einsele H, Jost E, Brummendorf TH, Scholl S, Hochhaus A, Neubauer A, Sohlbach K, Fransecky L, Kaufmann M, Niemann D, Schaich M, Frickhofen N, Kiani A, Heits F, Krumpelmann U, Kaiser U, Kullmer J, Wass M, Stolzel F, von Bonin M, Middeke JM, Thiede C, Schetelig J, Berdel WE, Ehninger G, Baldus CD, Muller-Tidow C, Platzbecker U, Serve H, Bornhauser M. Does time from diagnosis to treatment affect the prognosis of patients with newly diagnosed acute myeloid leukemia? Blood. 2020 Aug 13;136(7):823-830. doi: 10.1182/blood.2019004583.
Related Links
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Website study alliance leukemia
Other Identifiers
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SAL-AML-REG-BIO
Identifier Type: -
Identifier Source: org_study_id
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