Survival in Patients Older Than 60 Years With Newly Diagnosed AML in Spain

NCT ID: NCT03435341

Last Updated: 2021-05-21

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

151 participants

Study Classification

OBSERVATIONAL

Study Start Date

2018-02-28

Study Completion Date

2020-04-30

Brief Summary

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Prospective, multicenter, observational, national study (EPA-SP) that aims to describe the survival and the quality of life, the clinical management strategies and the prognostic factors for survival related to the patient, in a prospective cohort of patients over 60 with AML diagnosis in Spain and treated outside of clinical trials; that is, under conditions of standard clinical practice.

The study will last 24 months in total from the inclusion of the first patient until the end of the last patient's follow-up

Detailed Description

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Following the baseline enrolment visit, the following data corresponding to the patient's visits scheduled according to routine clinical practice will be collected in accordance with the following model:

1. Recruitment period: One year of recruitment period, data collection at the baseline visit, every 3 months in one year (month 3, 6, 9 and 12).
2. Follow-up period: data collection at the baseline visit, every 3 months in one year (month 3, 6, 9 and 12).

The patient clinical history and the study´s questionnaires will be the source documents. The study will be carried out in the facilities of the Hematology and Hemotherapy Services of the participating centers, collecting the conditions of medical action according to the standard clinical practice.

Being an observational study, no intervention out of standard clinical practice will be performed. No additional diagnostic or treatment procedures will be applied for the patients.

Conditions

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Leukemia, Myeloid, Acute

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Patients diagnosed with AML

The study population will consist of approximately 150 patients over 60 with AML diagnosis according to WHO 2016 criteria.

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Patient of both sexes, aged 65 years and older.
* Any race, nationality or socioeconomic status.
* AML (defined according to WHO 2016 criteria de novo, with previous hematological history or secondary.
* Diagnosis date later than 1st November 2017 and later than each center activation date.
* Patients on first line treatment with any therapeutic strategy (intensive, attenuated or palliative).
* Having given informed consent prior to start the data collection.

Exclusion Criteria

* Inability to understand the informed consent form.
* AML previously treated (with or without HSCT).
* Acute promyelocytic leukemia.
* Participation in a clinical trial that includes first-line treatment for AML.
* Do not grant consent.
Minimum Eligible Age

60 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Celgene

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Montserrat Rafel, RML Advocacy

Role: STUDY_DIRECTOR

Celgene

Locations

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Hospital de Jerez

Jerez de la Frontera, Andalucía/Cádiz, Spain

Site Status

Hospital Virgen de las Nieves

Granada, Andalucía/Granada, Spain

Site Status

Hospital Carlos Haya

Málaga, Andalucía/Málaga, Spain

Site Status

Hospital Virgen del Rocio

Seville, Andalucía/Sevilla, Spain

Site Status

Hospital Universitario Nuestra Señora de Valme

Seville, Andalucía/Sevilla, Spain

Site Status

Hospital Univ. Reina Sofia

Córdoba, Andalusia, Spain

Site Status

Hospital Universitario Virgen Macarena

Seville, Andalusia, Spain

Site Status

Hospital Clínico Lozano Blesa

Zaragoza, Aragon, Spain

Site Status

Hospital Son Espases

Palma de Mallorca, Balearic Islands, Spain

Site Status

Hospital de Basurto

Bilbao, Vizcaya, Basque Country, Spain

Site Status

Hospital Universitario de Donostia

San Sebastián, Guipúzcoa, Basque Country, Spain

Site Status

Hospital de Txagorritxu

Vitoria-Gasteiz, Basque Country, Spain

Site Status

Hospital Dr. Negrín

Las Palmas de Gran Canaria, Canary Islands, Spain

Site Status

Hospital Nuestra Señora de Candelaria

Santa Cruz de Tenerife, Canary Islands, Spain

Site Status

Hospital Universitario Canarias

Santa Cruz de Tenerife, Canary Islands, Spain

Site Status

Hospital Universitario de Burgos

Burgos, Castille and León, Spain

Site Status

Hospital de León

León, Castille and León, Spain

Site Status

Complejo Hospitalario de Salamanca

Salamanca, Castille and León, Spain

Site Status

Clínico de Valladolid

Valladolid, Castille and León, Spain

Site Status

Hospital del Mar

Barcelona, Catalonia, Spain

Site Status

Hospital Arnau de Vilanova Lleida

Lleida, Catalonia, Spain

Site Status

Hospital de Althaia (H. Sant Juan de Deu de Manresa)

Manresa, Barcelona, Catalonia, Spain

Site Status

Hospital Infanta leonor

Madrid, Comunidad Madrid, Spain

Site Status

Hospital Infanta Cristina

Badajoz, Extremadura, Spain

Site Status

Complejo Hospitalario Universitario de A Coruña

A Coruña, Galicia, Spain

Site Status

Complejo Hospitalario Universitario de Orense

Ourense, Galicia, Spain

Site Status

Hospital Santa Lucía

Cartagena, Murcia, Murcia, Spain

Site Status

Complejo Hospitalario de Navarra

Pamplona, Navarra, Navarre, Spain

Site Status

Hospital Universitario Cabueñes

Gijón, Principality of Asturias, Spain

Site Status

Hospital Universitario Central de Asturias

Oviedo, Principality of Asturias, Spain

Site Status

Hospital General Alicante

Alicante, Valencia, Spain

Site Status

Hospital General Universitario de Valencia

Valencia, Valencia, Spain

Site Status

Hospital Universitario La Princesa

Madrid, , Spain

Site Status

Hospital Universitario Ramón y Cajal

Madrid, , Spain

Site Status

Fundación Jiménez Díaz

Madrid, , Spain

Site Status

Hospital Clínico San Carlos

Madrid, , Spain

Site Status

Hospital Universitario 12 de Octubre

Madrid, , Spain

Site Status

Hospital Universitario La Paz

Madrid, , Spain

Site Status

Hospital de Fuenlabrada

Madrid, , Spain

Site Status

Hospital de Getafe

Madrid, , Spain

Site Status

Countries

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Spain

Other Identifiers

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U1111-1207-6661

Identifier Type: REGISTRY

Identifier Source: secondary_id

NDS-AML-001

Identifier Type: -

Identifier Source: org_study_id

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