Clinical Study of Umbilical Cord Mesenchymal Stem Cells (UC-MSC) for Treatment of Knee Osteoarthritis
NCT ID: NCT03166865
Last Updated: 2018-06-04
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
PHASE1/PHASE2
60 participants
INTERVENTIONAL
2018-10-01
2020-10-01
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
DOUBLE
Study Groups
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Intervention group
Intraarticular injection of 2×10\~7 Umbilical-cord mesenchimal stem cells with plateler Rich Plasma(5ml)
Umbilical-cord mesenchymal stromal cells (UC-MSCs)
Allogeneic UC-MSCs 1 x 10\~7 diluted on 5 mL of Platelet Rich Plasma
Control group
Intraarticular injection of hyaluronic acid
Hyaluronic acid
intra-articular injection of Hyaluronic Acid
Interventions
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Umbilical-cord mesenchymal stromal cells (UC-MSCs)
Allogeneic UC-MSCs 1 x 10\~7 diluted on 5 mL of Platelet Rich Plasma
Hyaluronic acid
intra-articular injection of Hyaluronic Acid
Eligibility Criteria
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Inclusion Criteria
* No serious infection, chronic diseases, diabetes and tuberculosis.
* Osteoarthritis of the knee with grade1-3 defined by the modified Kellgren-Lawrence classification.
* Written informed consents were obtained from all subjects.
Exclusion Criteria
* Inflammatory or post infectious arthritis.
* Intra-articular drug injection within the previous 2 months.
* Serious medical illness with a life expectancy of less than 1 year.
* Prior admission for substance abuse.
* Arthroscopy during the previous 6 months.
* Systemic autoimmune rheumatic disease.
* Poorly controlled diabetes mellitus.
* Immunosuppressive or anticoagulant treatments.
* Treatment with corticosteroids in the 3 months prior to inclusion in the study.
* NSAID therapy within 15 days prior to inclusion in the study.
30 Years
70 Years
ALL
No
Sponsors
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Liaocheng People's Hospital
OTHER
Responsible Party
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Principal Investigators
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Dawang Wang, Ph.D.
Role: STUDY_DIRECTOR
Liaocheng People's Hospital
Locations
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Liaocheng city people's hospital
Liaocheng, Shandong, China
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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lcsrmyygk
Identifier Type: -
Identifier Source: org_study_id
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