Human Umbilical Cord Mesenchymal Stem Cells in the Treatment of Knee Osteoarthritis

NCT ID: NCT05160831

Last Updated: 2021-12-16

Basic Information

• Recruitment Status: UNKNOWN
• Clinical Phase: NA
• Total Enrollment: 50 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2022-01-20
• Study Completion Date: 2024-01-20

Brief Summary

This study aims to investigate the effectiveness and safety of human umbilical cord mesenchymal stem cell injection in the articular cavity to treat moderate to severe knee osteoarthritis (OA), and whether it can achieve articular cartilage regeneration, reduction of joint pain, and restoration of joint function.

Detailed Description

There are more than 100 types of arthritis, and the most common ones are rheumatoid arthritis (RA) and osteoarthritis (OA). The main cause of its pathogenesis is the compensatory hyperplasia of the articular cartilage caused by the body's degenerative changes, which will eventually cause the joint to partially or completely lose its function.

In the past few decades, continuous efforts have been made to treat OA. The treatment of OA changes with the development of the patient's condition. At present, there are many diagnosis and treatment options for knee OA, including conservative treatment and surgical treatment. There is an urgent need for an effective treatment to postpone or terminate the course of OA.

Cell therapy for OA has developed rapidly in recent years and has received widespread attention. Mesenchymal stem cells (MSCs) are pluripotent stem cells with potential of self-renewal, proliferation and differentiation. Stem cells are extracted from the patient's body and then implanted back. Their ability of regeneration and reproduction can fill the damaged cartilage tissue, so as to achieve an effective treatment of the joint damage.

This study aims to investigate the effectiveness and safety of human umbilical cord mesenchymal stem cell injection in the articular cavity to treat moderate to severe knee osteoarthritis (OA), and whether it can achieve articular cartilage regeneration, reduction of joint pain, and restoration of joint function.

Conditions

Knee Osteoarthritis

Keywords

knee joint; osteoarthritis; human umbilical cord mesenchymal stem cells

Study Design

• Allocation Method: NA
• Intervention Model: SINGLE_GROUP
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

Human umbilical cord mesenchymal stem cells

Human umbilical cord mesenchymal stem cells injection is applied for knee OA patients.

Group Type: EXPERIMENTAL

Human umbilical cord mesenchymal stem cells

Intervention Type: BIOLOGICAL

Human umbilical cord mesenchymal stem cell injection is applied for treating knee OA patients.

Interventions

Human umbilical cord mesenchymal stem cells

Human umbilical cord mesenchymal stem cell injection is applied for treating knee OA patients.

Intervention Type: BIOLOGICAL

Eligibility Criteria

Inclusion Criteria

• Patients who have no major organ dysfunction.
• Diagnosed as moderate to severe knee osteoarthritis according to internationally recognized criteria: a). Meets the criteria of the "Guidelines for the Diagnosis and Treatment of Osteoarthritis (2018 Edition)" revised by the Chinese Medical Association Rheumatology Branch in 2018; b). Meets the criteria of Grade 3 or more according to the American College of Rheumatology (ACR); c).Meets the criteria of Grade Ⅲ or more according to Kellgren-Lawrence's OA radiology grading standard.
• Those who have the ability to move independently, except those who use wheelchairs, walkers or crutches, and who have no history of mental illness.
• There is no obvious contraindication to articular cavity injection in hematology and biochemical testing.
• No local or systemic infection.
• Subjects and their families understand the clinical trial protocol and agree to participate in the trial, and sign a written Informed Consent.
• Patients whose pain has lasted for more than half a year, and the routine clinical treatment of oral hormones, opioids and other drugs have been ineffective.

Exclusion Criteria

• Those who are older than 70 years old or younger than 18 years old, or have no full capacity for civil conduct.
• HIV, hepatitis virus or syphilis virus infection or positive serological test.
• Body mass index (BMI) greater than 30 kg/m2.
• Congenital or acquired knee deformity; severe knee arthritis accompanied by severe varus deformity, with varus greater than 10°.
• Pregnant or lactating women, or women of childbearing age who have a positive pregnancy test within 7 days before receiving treatment.
• Complicated with severe cardiovascular and cerebrovascular, liver, kidney, and endocrine, blood system diseases, malignant tumors, allergies, mental disorders, acute infections or local knee joint infections.
• Patients with immunodeficiency.
• Patients with a history of intra-articular injection within 3 months; patients being treated with immunosuppressive agents and glucocorticoids.
• Patients who are still participating in other clinical trials.
• Subjects who refuse to sign Informed Consent or refuse to participate in this clinical trial.

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 70 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Southwest Hospital, China

OTHER

Sponsor Role: lead

Responsible Party

Liu Yang, MD

Professor of Center for Joint Surgery

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Liu Yang, MD

Role: PRINCIPAL_INVESTIGATOR

Center for Joint Surgery, Southwest Hospital, China

Fuyou Wang, MD

Role: PRINCIPAL_INVESTIGATOR

Center for Joint Surgery, Southwest Hospital, China

Central Contacts

Fuyou Wang, MD

Role: CONTACT

Phone: 86-23-68765290

Email: arthro@126.com

Other Identifiers

SCforKneeOA

Identifier Type: -

Identifier Source: org_study_id