Impulsivity and Time Perception

NCT ID: NCT03162640

Last Updated: 2023-08-29

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 38 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2017-05-05
• Study Completion Date: 2020-03-12

Brief Summary

Cannabis smokers having begun prematurely their consumption (before 16 years) present a persistent impulsivity much later after have stopped their consumptions. The literature highlights that the impulsivity promotes the passage towards a compulsive consumption, and the loss of control. To explain this phenomenon, some authors hypothesized that impulsivity would lead the subjects to overestimate the duration of events and to choose immediate rewards than preferred but delayed rewards. This hypothesis questions the role of the temporal anticipation in the impulsive choices. In a first hypothesis, the temporal impulsivity could be an endogenous deficit bound to the reward, and would be responsible for disorders of the temporal anticipation. In this case, the disorders should be observed especially when the subject anticipates a reward. Alternately, a disorder of the temporal anticipation could provoke impulsivity, and in this case, would be present with or without reward. To separate these hypotheses, we propose to test the capacities of temporal anticipation of non-smokers and early smokers of cannabis by means of a behavioral task " Hazard function task ", which allow to measure the capacity of a subject to anticipate the apparition of an event on the basis of a temporal cue. The neuronal correlates will be measured by a recording EEG of the wave ' CNV ' (fix a quota for denial of variation) which reflects the temporal accumulation and the processes of anticipation.

Conditions

Cannabis Use

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: PROSPECTIVE

Study Groups

P

for cannabis

No interventions assigned to this group

C

for the control group

No interventions assigned to this group

Eligibility Criteria

Inclusion Criteria

• Healthy volunteers Man or woman of age between 18 and 50 years-old
• Absence of consumption of cannabis and tobacco for 1 year and absence of substance use disorder in history
• Matching in age and sex to the group consumers of cannabis
• Early consumers of cannabis (at the beginning of the consumptions before 16 years)
• Man or woman of age between 18 and 50 years old
• Statement of more than three consumptions a day of cannabis for at least one year and consumption of cannabis having begun before the age of 16 years.
• Urinary analysis is positive for the presence of cannabis
• Positive auto-questionnaire CAST: 2 positive answers to CAST questionnaire
• Hospitalized or not

Exclusion Criteria

• Presence or history of a severe and invalidating somatic pathology (neurological, cardiovascular, lung, metabolic, renal, hepatic, gastro-intestinal)

• History of cranial trauma with loss of consciousness.
• substance use disorder except the substance tested in the protocol (cannabis).
• Invalidating sensory disorders in particular visual: glaucoma, any retinal pathology. Visual acuteness 0.8
• History of general anesthesia in the previous 3 months the study
• Any evolutionary neurological or psychiatric pathology
• Subject under guardianship
• pregnancy
• Feeding

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 50 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

University Hospital, Strasbourg, France

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Laurence LALANNE-TONGIO, MD

Role: PRINCIPAL_INVESTIGATOR

Hôpitaux Universitaires de Strasbourg

Locations

Les Hôpitaux Universitaires de Strasbourg

Strasbourg, Alsace, France

Countries

France

Other Identifiers

6526

Identifier Type: -

Identifier Source: org_study_id