HIV Care Cascade and Linkage to Antiretroviral Therapy Among Hospitalized Adults in Lusaka, Zambia

NCT ID: NCT03158844

Last Updated: 2024-09-19

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

250 participants

Study Classification

OBSERVATIONAL

Study Start Date

2017-05-16

Study Completion Date

2018-05-31

Brief Summary

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The population of inpatients is large in Zambia; however, because of poor linkages between hospitals and community HIV care, there are few data to analyze their engagement in HIV care before and after hospitalization. The goal of the study is to learn more about Zambian adults who are HIV-infected and get hospitalized. The purpose of this study is to gather formative, preliminary data, to be used in future grant applications to improve linkage and engagement in HIV care in Zambia.

Detailed Description

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The main objective of this study is to generate preliminary data on the outcomes of Zambian HIV-infected individuals after discharge from University Teaching Hospital (UTH) Internal Medicine wards which can inform development of a linkage intervention. Our central hypothesis is that in Sub-Saharan African settings like Zambia hospitalizations among HIV-infected individuals are driven by suboptimal linkage and initiation of ART following HIV diagnosis. Specific Aims: (a) Characterize the distribution of hospitalized 300 HIV-infected adults across the HIV care continuum. (b) Identify structural, psychosocial, clinic, and medical factors that predict suboptimal linkage to care and ART initiation after 90 days of hospital discharge among HIV-infected Zambians.

Conditions

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Hiv

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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HIV+ patients (Standard of care)

300 HIV-infected and hospitalized adult patients at the University Teaching Hospital (UTH) will be recruited.

Standard of care

Intervention Type OTHER

Routine standard of care per Ministry of Health protocol, including blood draws and examinations.

Health systems informants

15 key Zambian health systems informants and leaders who can discuss inpatient care and the process of linking hospitalized patients to HIV care.

Standard of care

Intervention Type OTHER

Routine standard of care per Ministry of Health protocol, including blood draws and examinations.

Interventions

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Standard of care

Routine standard of care per Ministry of Health protocol, including blood draws and examinations.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* 18 years or older
* HIV-infected as documented in the UTH file
* Admitted to Internal Medicine Ward at UTH

Exclusion Criteria

* Unable to provide informed consent
* Not planning to remain in Lusaka province for 3 months after discharge
Minimum Eligible Age

18 Years

Maximum Eligible Age

99 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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University Teaching Hospital

UNKNOWN

Sponsor Role collaborator

Centre for Infectious Disease Research in Zambia

OTHER

Sponsor Role collaborator

University of Alabama at Birmingham

OTHER

Sponsor Role lead

Responsible Party

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Michael Vinikoor

Assistant Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Michael J Vinikoor, MD

Role: PRINCIPAL_INVESTIGATOR

University of Alabama at Birmingham

Locations

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University Teaching Hospital

Lusaka, , Zambia

Site Status

Countries

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Zambia

Other Identifiers

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F160812007

Identifier Type: -

Identifier Source: org_study_id

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