Prevelance of Fragmented QRS Complex and Prolonged QT Interval in Cirrhotic Patients
NCT ID: NCT03158701
Last Updated: 2017-05-18
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
100 participants
OBSERVATIONAL
2017-06-01
2018-06-01
Brief Summary
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.Cirrhotic patients with cardiac abnormality have higher mortality rates compared to patients without cardiac affection.
The suggested pathophysiologic mechanisms of cardiac affection in cirrhotic patients are; alterations in the beta-adrenergic signaling pathway and, myocardial fibrosis formation, sympathetic nervous system activation and changes in ion channels.
.As a component of cardiac involvement in cirrhotic patients fragmented QRS complex and prolongation of the corrected QT interval has been documented in most of the cases with liver cirrhosis (LC) and its prevalence increases with the severity of the disease
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Detailed Description
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.Cirrhotic patients with cardiac abnormality have higher mortality rates compared to patients without cardiac affection.
The suggested pathophysiologic mechanisms of cardiac affection in cirrhotic patients are; alterations in the beta-adrenergic signaling pathway and, myocardial fibrosis formation, sympathetic nervous system activation and changes in ion channels.
.As a component of cardiac involvement in cirrhotic patients fragmented QRS complex and prolongation of the corrected QT interval has been documented in most of the cases with liver cirrhosis (LC) and its prevalence increases with the severity of the disease.
.Fragmented QRS (fQRS) is a convenient marker of myocardial scar evaluated by 12-lead electrocardiogram (ECG) recording. fQRS is defined as additional spikes within the QRS complex. In patients with CAD, fQRS was associated with myocardial scar detected by single photon emission tomography and was a predictor of cardiac events. fQRS was also a predictor of mortality and arrhythmic events in patients with reduced left ventricular function. The usefulness of fQRS for detecting myocardial scar and for identifying high-risk patients has been expanded to various cardiac diseases, such as cardiac cirrhosis, arrhythmogenic right ventricular cardiomyopathy, acute coronary syndrome. fQRS can be caused by zigzag conduction around the scarred myocardium, resulting in multiple spikes within the QRS complex .
Conditions
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Study Design
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COHORT
PROSPECTIVE
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
2. Patients known to be hypertensive
3. patients with documented significant coronary artery disease
4. patients taking drugs that affect QT interval
18 Years
ALL
No
Sponsors
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Assiut University
OTHER
Responsible Party
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Fady Refaat Edwar Nasrallah
internal medicine resident,Assiut University hospital
Other Identifiers
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assiut university 7000
Identifier Type: -
Identifier Source: org_study_id
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