Prevalence of Early Childhood Caries in Egyptian Children With Serum Vitamin D Deficiency.

NCT ID: NCT03158155

Last Updated: 2017-06-07

Basic Information

• Recruitment Status: UNKNOWN
• Total Enrollment: 288 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2017-07-15
• Study Completion Date: 2018-07-18

Brief Summary

To detect the effect of vitamin D deficiency in the development of early childhood caries (ECC) among Egyptian children.

Detailed Description

Justification for undertaking the trial:

American Academy of Pediatric Dentistry (2012), defined early childhood caries (ECC) as the presence of one or more decayed, missing teeth (resulting from caries), or filled surfaces in the primary tooth of child 6 years old or younger.

Early childhood caries is a chronic childhood disease, that decreasing quality of life, this include pain, disturbed sleep, poor aesthetics, difficulty in eating and speaking and behavioral changes that affect the child's self-esteem. (Guay, 2004).

Due to the rising incidence of dental carries in early childhood, contributory factors need to be investigated in order to facilitate treatment of such a large population of children in desperate need of dental care (Guay, 2004).These multiple risk factors include the lack of a dental home, poor oral hygiene, diet, and nutrition ( Najeeb et al., 2016).

Enamel is the most mineralized substance in the human body; it is mainly made of calcium and phosphate. Vitamin D plays an important role in increasing the absorption of calcium and phosphate from food. Which calcium and phosphate improve the strength of the teeth as make them able to fight the demineralization from bacteria (Youssef et al., 2011). Therefore, it is responsible of promoting the calcification of teeth, having a topical fluoride like effect, and in the forming of enamel, dentin, and bone. (Mellanby & Pattison, 1928).

Vitamin D receptors are present on the cells of immune system and on the teeth. It binds to these receptors and increases the amount of good antimicrobial proteins as cathelicidin and other special defense in saliva (Youssef et al., 2011). These antimicrobial peptides have antibacterial neutralizing activity against periodonto pathogens as gram negative and gram positive bacteria and candida albicans, its effective in vitro against oral microorganisms such as streptococcus mutants, prophyromonas gingivalis and actinobacillus, so it prevents dental caries.( Potturu et al., 2014).

East, (1939) study concluded that children who consumed a high vitamin D diet, vitamin D played an indispensable role in 1) preventing the initiation of new caries, 2) inhibiting the spread of existing caries, and 3) arresting the caries. Likewise, an examination of children found a decreased caries prevalence in areas of increased vitamin D exposure.

Conditions

Vitamin D Deficiency

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: CROSS_SECTIONAL

Study Groups

Patients with vitamin D deficiency

1\. children with vitamin D deficiency with age group from 2-5 years old

No interventions assigned to this group

Eligibility Criteria

Inclusion Criteria

1. Children ages from two to five years

2. Both sexes.

3. Parent and children cooperation.

4. Healthy children.

5. Children with serum vitamin D deficiency.

Exclusion Criteria

1. Children age more than 5 years.

2. Children had a complex metabolic or medical disorder.

3. Parents that will not sign the consent.

• Minimum Eligible Age: 2 Years
• Maximum Eligible Age: 5 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

Nancy Ahmed El Salmawy

OTHER

Sponsor Role: lead

Responsible Party

Nancy Ahmed El Salmawy

Principal Investigator,

Responsibility Role: SPONSOR_INVESTIGATOR

Principal Investigators

Nourhan A. El dokky, A. Professor

Role: STUDY_DIRECTOR

neldokky@hotmail.com

Central Contacts

Nancy A El salmawy, Master

Role: CONTACT

nancyyy_911@hotmain.com

+201001891010

References

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Reference Type: BACKGROUND

PMID: 27931420 (View on PubMed)

Anthonappa, R. P., and King, N. M. (2015). Enamel defects in the permanent dentition: prevalence and etiology. Springer-Verlag Berlin Heidelberg 2015; B.K. Drummond, N. Kilpatrick (eds.), Planning and Care for Children and Adolescents with Dental Enamel Defects: Etiology, Research and Contemporary Management, pp. 15-30

Reference Type: BACKGROUND

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Reference Type: BACKGROUND

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Reference Type: BACKGROUND

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Other Identifiers

CEBD-2017-5-101

Identifier Type: -

Identifier Source: org_study_id