MMP-7 Modulation by Short and Long Term Radiotherapy in Rectal Cancer Patients

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

77 participants

Study Classification

OBSERVATIONAL

Study Start Date

2002-11-06

Study Completion Date

2007-03-16

Brief Summary

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To analyse the effects of radiation therapy on inflammation and matrilysin levels in rectal cancer patients.

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Detailed Description

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Conditions

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Rectal Cancer

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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No radiotherapy

Surgery only

No interventions assigned to this group

25 Gray radiotherapy

Surgery after short term radiotherapy

Neoadjuvant radiotherapy

Intervention Type RADIATION

Neoadjuvant radiotherapy prior to rectal cancer surgery

50 Gray radiotherapy

Surgery after long term radiotherapy

Neoadjuvant radiotherapy

Intervention Type RADIATION

Neoadjuvant radiotherapy prior to rectal cancer surgery

Interventions

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Neoadjuvant radiotherapy

Neoadjuvant radiotherapy prior to rectal cancer surgery

Intervention Type RADIATION

Eligibility Criteria

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Inclusion Criteria

Adenocarcinoma of the rectum, ability to understand written and oral information, written consent.

Exclusion Criteria

Colon cancer, benign tumors, impaired general condition of patient, declining to participate in the study, synchronous colonic tumors, logistical reasons, inability to understand written and/or oral information, previous pelvic irradiation, ongoing immunosuppressive therapy, diabetes with systemic complications.

Eligible Sex

ALL

Accepts Healthy Volunteers

No