Online Adaptive Radiation Therapy for Rectal Cancer

NCT ID: NCT05911789

Last Updated: 2023-08-01

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

PHASE1/PHASE2

Total Enrollment

15 participants

Study Classification

INTERVENTIONAL

Study Start Date

2023-08-05

Study Completion Date

2025-06-01

Brief Summary

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In the present study, the investigators will evaluate the efficacy, toxicities, and of online adaptive radiation therapy (ART) for patients with rectal cancer treated with neoadjuvant chemoradiotherapy.

Detailed Description

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Conditions

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Rectal Cancer

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Online adaptive radiation therapy

Patients receive adaptive radiotherapy therapy and concurrent chemotherapy.

Group Type EXPERIMENTAL

Online adaptive radiation therapy

Intervention Type RADIATION

A dose of 45Gy will be delivered to planning target volume (PTV)

Interventions

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Online adaptive radiation therapy

A dose of 45Gy will be delivered to planning target volume (PTV)

Intervention Type RADIATION

Other Intervention Names

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ART

Eligibility Criteria

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Inclusion Criteria

1. ≥18 years old;
2. Diagnose with rectal cancer;
3. T3-T4 or N+, and no distant metastasis
4. Neoadjuvant chemoradiotherapy intended;
5. Surgery is expected after neoadjuvant therapy;
6. ECOG score 0-2, expected to lie in the treatment bed for at least half an hour;

Exclusion Criteria

1. With contraindications to rectal MRI;
2. Received surgery, radiotherapy or chemotherapy for rectal cancer;
3. History of pelvic radiotherapy.
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Peking Union Medical College Hospital

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Other Identifiers

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ART-rectal cancer

Identifier Type: -

Identifier Source: org_study_id

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