Study Results
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View full resultsBasic Information
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COMPLETED
40 participants
OBSERVATIONAL
2015-11-01
2018-06-30
Brief Summary
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The aim of the study: Evaluation of the relationship between GCX damage and duration of various organ supporting measures.
Type of the study: Observational. Subjects: Adult patients admitted to ICU and requiring organ supporting therapy.
Sample size: We plan enrollment of 75 patients on invasive ventilatory support in the duration of least 5 days, 50 patients on renal supporting therapy lasting at least 5 days and 20 patients with target temperature management for neuroprotection.
Intervention: none Data to be recorded and analysed: Demographics, type of patients (trauma, post surgical, medical, after cardiac arrest), severity score - Apache II, SOFA, fluid balance, presence of delirium, clinical outcome, sublingual microcirculation by SDF imaging at time points: before or at the start of organ support, after 24 hours (day 1), day 3, 5, 7 and/or at discharge or before death, microcirculatory data, and Perfused Boundary Region.
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Detailed Description
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Conditions
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Study Design
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COHORT
PROSPECTIVE
Study Groups
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Patients on artificial ventilation
PBR assessment
Sublingual microcirculation will be investigated by specialized handheld videomicroscopy device for PBR index.
Patients on renal replacement therapy
PBR assessment
Sublingual microcirculation will be investigated by specialized handheld videomicroscopy device for PBR index.
Patients with targeted temperature management
PBR assessment
Sublingual microcirculation will be investigated by specialized handheld videomicroscopy device for PBR index.
Interventions
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PBR assessment
Sublingual microcirculation will be investigated by specialized handheld videomicroscopy device for PBR index.
Eligibility Criteria
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Inclusion Criteria
* artifitial ventilation
* renal replacement therapy
* targeted temperatura management
Exclusion Criteria
18 Years
ALL
No
Sponsors
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University Hospital Hradec Kralove
OTHER
Responsible Party
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Vladimir Cerny
Clinical Professor
Principal Investigators
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Vladimir Cerny, MD, PhD, FCCM
Role: PRINCIPAL_INVESTIGATOR
University Hospital Hradec Kralove
Locations
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University Hospital Hradec Kralove
Hradec Králové, Třebeš, Czechia
Countries
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Provided Documents
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Document Type: Study Protocol and Statistical Analysis Plan
Other Identifiers
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AZVCR 9307_3
Identifier Type: -
Identifier Source: org_study_id
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