LYmphangiogenesis FacTors in Heart Failure States

NCT ID: NCT03141567

Last Updated: 2023-07-14

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

100 participants

Study Classification

OBSERVATIONAL

Study Start Date

2017-05-18

Study Completion Date

2023-01-24

Brief Summary

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Heart failure often causes fluid to accumulate in the body, leading to congestion and swelling. However, some people who have had heart failure for a long time seem to have very little congestion or swelling, even when the heart failure is poorly treated. The investigators think that this is because lymphatic vessels are able to grow and remove fluid to prevent congestion. The investigators do not know how lymphatic vessels grow. This study will investigate the blood levels of various proteins to try to figure out how the lymph vessels of people with long-standing heart failure might grow.

Detailed Description

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Conditions

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Heart Failure Heart Failure With Reduced Ejection Fraction Heart Failure With Normal Ejection Fraction

Study Design

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Observational Model Type

OTHER

Study Time Perspective

OTHER

Study Groups

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Outpatient

Individuals undergoing clinically indicated Right Heart Catheterization.

No interventions assigned to this group

Inpatient

Individuals undergoing clinically indicated Right Heart Catheterization.

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Undergoing clinically indicated right heart catheterization.

Exclusion Criteria

* Unable to provide consent.
* Use of medications which may alter lymphangiogenesis factor expression within 365 days
* Thalidomide, lenalidomide, pomalidomide
* Bevacizumab
* Any cytotoxic chemotherapy agents
* Pregnant
* Any potentially pregnant patient (based on age and gender) undergoes Beta Human chorionic gonadotropin testing as standard of care prior to any right heart catheterization.
* Active cancer within 365 days
* Diagnosis of familial or secondary lymphedema
* Treatment of active bacterial infection within 7 days
* Active inflammatory rheumatologic disease requiring anti-inflammatory therapy administration within 60 days
* Conditions
* Systemic lupus erythematosus
* Rheumatoid arthritis
* Scleroderma
* Inflammatory myositis
* Vasculitis
* Behcet's disease
Minimum Eligible Age

18 Years

Maximum Eligible Age

99 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Medical University of South Carolina

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Brian Houston, M.D.

Role: PRINCIPAL_INVESTIGATOR

Assistant Professor

Locations

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Ralph H. Johnson VAMC

Charleston, South Carolina, United States

Site Status

Medical University of South Carolina

Charleston, South Carolina, United States

Site Status

Countries

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United States

Other Identifiers

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Pro00062457

Identifier Type: -

Identifier Source: org_study_id

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