UVX as an Adjuvant in the Treatment of Fungal Keratitis
NCT ID: NCT03138785
Last Updated: 2017-05-03
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
NA
20 participants
INTERVENTIONAL
2015-01-01
2017-07-01
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
SINGLE
Study Groups
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conventional treatment
In this arm, patients with documented fungal keratitis undergo conventional medical treatment.
topical voriconazole / levofloxacin systemic itraconazole
starting topical voriconazole every hour tapering after 4 days , levofloxacin every 6 hours, Itraconazole 100mg /BD for 2 weeks
conventional treatment +CXL
In this arm, patients with documented fungal keratitis undergo conventional medical treatment plus CXL, beginning on the first day
topical voriconazole / levofloxacin systemic itraconazole
starting topical voriconazole every hour tapering after 4 days , levofloxacin every 6 hours, Itraconazole 100mg /BD for 2 weeks
CXL
30 min Riboflavin prescription to the cornea followed by 30 min UV-A radiation at 3mW/cm2 associated with Riboflavin administration
Interventions
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topical voriconazole / levofloxacin systemic itraconazole
starting topical voriconazole every hour tapering after 4 days , levofloxacin every 6 hours, Itraconazole 100mg /BD for 2 weeks
CXL
30 min Riboflavin prescription to the cornea followed by 30 min UV-A radiation at 3mW/cm2 associated with Riboflavin administration
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
* Thinning at presentation
* Perforation
* Associated with other microbial or viral keratitis
ALL
No
Sponsors
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Farabi Eye Hospital
OTHER
Responsible Party
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mohammad soleimani
assistant professor
References
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Davis SA, Bovelle R, Han G, Kwagyan J. Corneal collagen cross-linking for bacterial infectious keratitis. Cochrane Database Syst Rev. 2020 Jun 17;6(6):CD013001. doi: 10.1002/14651858.CD013001.pub2.
Other Identifiers
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32768
Identifier Type: -
Identifier Source: org_study_id
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