Effects of Regional Nerve Block on Cancer Recurrence

NCT ID: NCT03134430

Last Updated: 2018-05-25

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

400 participants

Study Classification

INTERVENTIONAL

Study Start Date

2017-07-10

Study Completion Date

2023-05-01

Brief Summary

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It has been reported local anesthetics could inhibit tumor cell proliferation, metastasis and invasion ability,but it is still lack of clinical evidence. Our study aims to explore the effects of regional nerve block on cancer recurrence and the mechanism.

Detailed Description

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1. To study the effects of TAP block under ultrasound guide on the recurrence of gastric carcinoma, colon cancer, rectal carcinoma and liver cancer and the underlying mechanisms.
2. To clarify the effects of Lateral thoracic nerve block under ultrasound guide on the recurrence of lung cancer and the underlying mechanisms.

Conditions

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Cancer Patient

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

the patients in treatment group will received reginoal nerve block with 0.35% Ropivacane and 0.5% lidocaine in normal saline under ultrasound guide, while those in control group received equal volume of normal saline.
Primary Study Purpose

TREATMENT

Blinding Strategy

QUADRUPLE

Participants Caregivers Investigators Outcome Assessors

Study Groups

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Normal saline

equal volume of normal saline as treatment group

Group Type PLACEBO_COMPARATOR

Normal saline

Intervention Type OTHER

Injection of Normal saline around peripheral nerve

peripheral Nerve block

0.35% ropivacaine and 0.5% lidocaine in normal saline

Group Type ACTIVE_COMPARATOR

peripheral Nerve block

Intervention Type OTHER

Injection of local anesthetics around peripheral nerve

Interventions

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Normal saline

Injection of Normal saline around peripheral nerve

Intervention Type OTHER

peripheral Nerve block

Injection of local anesthetics around peripheral nerve

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Patients with primary cancer undergoing elective surgery under general anesthesia

Exclusion Criteria

* Disagree to participate,drop out,lose track, infectious abdominal wall,abnormal puncture point,coagulation dysfunction,allergy of local anesthetic ,immune disease,cancer metastasis,mental disease, acute and chronic infectious disease or other severe disease.
Minimum Eligible Age

18 Years

Maximum Eligible Age

80 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Luo Foquan

OTHER

Sponsor Role lead

Responsible Party

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Luo Foquan

Professor

Responsibility Role SPONSOR_INVESTIGATOR

Principal Investigators

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Foquan Luo, professor

Role: STUDY_CHAIR

The First Affiliated Hospital of Nanchang University

Locations

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The first affiliated hospital of nanchang university

Nanchang, Jiangxi, China

Site Status

Countries

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China

Other Identifiers

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LFoquan

Identifier Type: -

Identifier Source: org_study_id

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