Combination of Irreversible Electroporation and NK Immunotherapy for Recurrent Liver Cancer
NCT ID: NCT03008343
Last Updated: 2019-09-12
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
PHASE1/PHASE2
20 participants
INTERVENTIONAL
2016-12-01
2019-07-01
Brief Summary
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Detailed Description
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The safety will be evaluated by statistics of adverse reactions. The efficacy will be evaluated according to local relief degree, progress free survival (PFS) and overall survival (OS).
Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
SINGLE
Study Groups
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Electroporation and natural killer
In this group, the patients will receive regular irreversible electroporation (IRE) treatment in combination with multiple natural killer (NK) immunotherapies. The check indexes are CT scan and blood tests (including tumor markers, lymphocyte subsets and circulating tumor cell).
Irreversible Electroporation
One kind of electric ablation machine from Angiodynamic company (USA)
Natural killer
Each treatment: 8-10 billion cells in all, transfuion in 3 times, i.v.
Electroporation
In this group, the patients will receive regular irreversible electroporation (IRE) treatment to control the tumor growth. The check indexes are CT scan and blood tests (including tumor markers, lymphocyte subsets and circulating tumor cell).
Irreversible Electroporation
One kind of electric ablation machine from Angiodynamic company (USA)
Interventions
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Irreversible Electroporation
One kind of electric ablation machine from Angiodynamic company (USA)
Natural killer
Each treatment: 8-10 billion cells in all, transfuion in 3 times, i.v.
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* Body tumor 1-6, the maximum tumor length \< 5 cm
* KPS ≥ 70, lifespan \> 6 months
* Platelet count ≥ 80×109/L，white blood cell count ≥ 3×109/L, neutrophil count ≥ 2×109/L, hemoglobin ≥ 80 g/L
Exclusion Criteria
* Patients with brain metastasis
* Patients with grade 3 hypertension or diabetic complication, severe cardiac and pulmonary dysfunction
30 Years
60 Years
ALL
No
Sponsors
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Shenzhen Hank Bioengineering Institute
OTHER
Fuda Cancer Hospital, Guangzhou
OTHER
Responsible Party
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Locations
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Fuda cancer institute of Fuda cancer hospital
Guangzhou, Guangdong, China
Countries
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Other Identifiers
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IRE-NK-Liver
Identifier Type: -
Identifier Source: org_study_id
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