Oxygen as a Limiting Factor for Performing Multitasking

NCT ID: NCT03126669

Last Updated: 2024-07-03

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 24 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2014-11-01
• Study Completion Date: 2017-03-25

Brief Summary

The aim of the present study was to evaluate whether hyperbaric oxygen (HBO) environment, with increased oxygen supply to the brain, will enable better performance of complex and/or multiple activities.

Detailed Description

The Brain uses 20% of the total oxygen supply consumed by the entire body. Even though, less than 10% of the brain is active at every given time, the brain utilizes almost all the oxygen delivered. In order to perform different tasks or more than one task (multi-tasking), the oxygen supply is shifted from one brain region to another, via modulation of blood perfusion.

The aim of the present study was to evaluate whether hyperbaric oxygen (HBO) environment, with increased oxygen supply to the brain, will enable better performance of complex and/or multiple activities.

Methods: a prospective, double blind randomized control, cross over trial including healthy volunteers. Participants were asked to perform a cognitive task, a motor task and a simultaneous cognitive-motor task (multi-tasking). Participants were randomized to perform the tasks at 2 environments: (a) normobaric air (1ATA 21% oxygen) (b) HBO (2ATA 100% oxygen). Two weeks later participants were crossed to the alternative environment. Blinding of the normobaric environment was achieved in the same chamber with masks on while hyperbaric sensation was simulated by increasing pressure in the first minute and gradually decreasing to normobaric environment prior to tasks performance.

Conditions

Cognitive Change

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: CROSSOVER
• Primary Study Purpose: SUPPORTIVE_CARE
• Blinding Strategy: SINGLE

Study Groups

Treratment

100% oxygen at 2 ATA at the hyperbaric chamber

Group Type: ACTIVE_COMPARATOR

Hyperbaric oxygen

Intervention Type: DEVICE

Breathing 100% oxygen at 2ATA in the hyperbaric chamber

Placebo

normal air, in the hyperbaric chamber

Group Type: PLACEBO_COMPARATOR

Hyperbaric chamber, normal air

Intervention Type: DEVICE

Hyperbaric chamber with normal air

Interventions

Hyperbaric oxygen

Breathing 100% oxygen at 2ATA in the hyperbaric chamber

Intervention Type: DEVICE

Hyperbaric chamber, normal air

Hyperbaric chamber with normal air

Intervention Type: DEVICE

Eligibility Criteria

Inclusion Criteria

• healthy volunteers,
• minimum of 12 years of formal education

Exclusion Criteria

• any inner ear pathologies,
• any lung disease,
• any mental or physical limitation of participat in going into oxygen chamber environment

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

Assaf-Harofeh Medical Center

OTHER_GOV

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Shai a Efrati, MD

Role: PRINCIPAL_INVESTIGATOR

Asaf-Harofhe MC

Locations

Assaf-Harofeh Medical Center

Ẕerifin, , Israel

Countries

Israel

Other Identifiers

213/13

Identifier Type: -

Identifier Source: org_study_id