Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
20 participants
OBSERVATIONAL
2017-08-29
2023-01-11
Brief Summary
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HYPOTHESIS: The TCA cycle rate will be lower in FRDA subjects than in controls APPROACH: The investigators will infuse carbon-13 (13C) labeled glucose and measure the rate of 13C label incorporation from glucose to glutamate in the brain using in vivo magnetic resonance spectroscopy.
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Detailed Description
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The investigators aim to obtain adequate data in 16 subjects grouped as follows:
* n=4 pilot subjects (healthy subjects) for testing and optimization of the experimental setup.
* n=6 healthy controls
* n=6 FRDA patients
In other to reach this goal, the investigators plan to recruit up to 20 subjects, in case some subjects withdraw before completion of the MR scan, or in case the measured data are not adequate (e.g. technical problem with the scanner).
Conditions
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Study Design
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CASE_CONTROL
PROSPECTIVE
Study Groups
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Control
Healthy subjects
MR
MR
Friedreich's Ataxia
Diagnosed for Friedreich's Ataxia
MR
MR
Interventions
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MR
MR
Eligibility Criteria
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Inclusion Criteria
* able to consent for themselves
* considered healthy (controls) OR be diagnosed with FRDA.
Exclusion Criteria
* Participants who cannot have an MRI, as determined by the CMRR safety screening form (e.g. metal implant)
* Pregnancy
* Clautrophobia
* Diabetes
* Clinically significant cardiac disease
Control subjects:
\- Neurological disease
18 Years
ALL
Yes
Sponsors
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University of Minnesota
OTHER
Responsible Party
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Principal Investigators
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Pierre-Gilles Henry, PhD
Role: PRINCIPAL_INVESTIGATOR
University of Minnesota
Locations
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CMRR
Minneapolis, Minnesota, United States
Countries
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Other Identifiers
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RAD-2017-25500
Identifier Type: -
Identifier Source: org_study_id
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