An Open-label Study of the Effects of Acetyl-L-Carnitine on Cardiovascular Outcomes in Friedreich's Ataxia

NCT ID: NCT01921868

Last Updated: 2016-04-12

Basic Information

• Recruitment Status: UNKNOWN
• Clinical Phase: NA
• Total Enrollment: 20 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2013-08-31
• Study Completion Date: 2017-06-30

Brief Summary

The purpose of this study is to learn how treatment with acetyl-L-carnitine (ALCAR) will affect the hearts of patients with Friedreich's Ataxia as well as how it may affect other symptoms of Friedreich's Ataxia such as difficulties with balance, walking, or upper arm function.

Detailed Description

This study is an open label, pilot study of ALCAR in subjects with FA. In this study 20 patients with FA will receive ALCAR every day for 24 months. At the study endpoint, subjects will be assessed for changes in cardiovascular outcomes and FA symptoms. To determine the effects of LC on changes in cardiomyopathy, echocardiography with strain rate will be calculated. This technique has been validated in clinical studies and used in other studies of FA patients for the comparison of regional deformation and myocardial wall thickness.

Conditions

Friedreich's Ataxia

Study Design

• Allocation Method: NA
• Intervention Model: SINGLE_GROUP
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

Acetyl-L-Carnitine

Open-label administration of Acetyl-L-Carnitine, up to 2 g/day for 24 months.

Group Type: EXPERIMENTAL

Acetyl-L-Carnitine

Intervention Type: DRUG

Acetyl-L-Carnitine, 2 g/day, up to 24 months.

Interventions

Acetyl-L-Carnitine

Acetyl-L-Carnitine, 2 g/day, up to 24 months.

Intervention Type: DRUG

Other Intervention Names

ALCAR

Eligibility Criteria

Inclusion Criteria

1. Outpatients with Friedreich's Ataxia diagnosed by a movement disorder specialist and confirmed by genetic testing (of the patient or in a first degree relative of the patient). Subject may be non-ambulatory.

2. Age 18 years to 80 years.

3. Stable medical condition for 3 months prior to screening.

4. Women of child-bearing potential must use a reliable method of contraception and must provide a negative pregnancy test at entry into the study.

5. If on cardiac medications such as beta-blockers or ace inhibitors, patients must be on a stable dose for 6 months prior to study entry and for the duration of the study.

6. Friedreich's Ataxia patients with systolic or diastolic dysfunction present on echocardiogram and ejection fraction between 35% - 65% at screening.

7. Subjects with ejection fractions < 50% need to be stable and on optimal heart failure therapy for at least 2 weeks prior to screening.

Exclusion Criteria

1. Any unstable illness or concomitant medical condition that, in the investigator's opinion, precludes participation in this study. This includes other disorders that may affect gait or balance (stroke, arthritis, etc).

2. Pregnancy or lactation.

3. Concurrent participation in another clinical study where use of an investigational product is used. Subjects who are currently enrolled in the Friedreich's Ataxia Clinical Outcome Measures Study at any site will be allowed to enroll in this study as well.

4. Any use of the investigational product within the past 30 days.

5. Dementia or other psychiatric illness that prevents the patient from giving informed consent (Mini Mental Status Exam score less than 25).

6. Legal incapacity or limited legal capacity.

7. History of stroke.

8. Subjects with a history of thyroid disease (hypothyroidism). Clinical laboratory evaluations of thyroid stimulating hormone levels taken 3 months prior to the study or at screening will be used to confirm absence of current thyroid problems.

9. Subjects with a history of seizures.

10. Subjects taking warfarin or acenocoumarol.

11. Presence of severe renal disease (estimated creatinine clearance <50 mL/min) or hepatic disease (AST or Alanine transaminase(ALT)>2x times normal) (as evidenced by labs reported within the past 6 months).

12. Clinically significantly abnormal white blood cell, hemoglobin or platelet count (as evidenced by labs reported within the past 6 months).

13. Subjects with blood work showing carnitine deficiency (<60nmol/mg total carnitine in the urine or <35umol/L total carnitine in the plasma).

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• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 80 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

University of South Florida

OTHER

Sponsor Role: lead

Responsible Party

Theresa Zesiewicz

Professor, Director of USF Ataxia Research Center

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Theresa A Zesiewicz, MD

Role: PRINCIPAL_INVESTIGATOR

University of South Florida

Locations

University of South Florida

Tampa, Florida, United States

Site Status: RECRUITING

Countries

United States

Central Contacts

Tanya Aranca, BS

Role: CONTACT

taranca@health.usf.edu

813-974-5909

Jessica Shaw, MPH

Role: CONTACT

jshaw@health.usf.edu

813-974-5909

Facility Contacts

Tanya Aranca, B.S.

Role: primary

taranca@health.usf.edu

813-974-5909

Jessica Shaw, MPH

Role: backup

jshaw@health.usf.edu

813-974-5909

Other Identifiers

ALCAR-8499

Identifier Type: -

Identifier Source: org_study_id