Safety And Efficacy of Sofosbuvir/Velpatasvir/Voxilaprevir Fixed-Dose Combination for 12 Weeks in Adults Who Participated in a Prior Gilead-Sponsored HCV Treatment Study

NCT ID: NCT03118843

Last Updated: 2019-04-03

Study Results

Results available

Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE3

Total Enrollment

31 participants

Study Classification

INTERVENTIONAL

Study Start Date

2017-04-25

Study Completion Date

2018-03-19

Brief Summary

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The primary objectives of this study are to determine the efficacy, safety, and tolerability of treatment with sofosbuvir/velpatasvir/voxilaprevir (SOF/VEL/VOX) fixed-dose combination (FDC) for 12 weeks in participants with chronic hepatitis C virus (HCV) infection with or without cirrhosis, who did not achieve sustained viral response (SVR) after receiving prior treatment in a Gilead-sponsored HCV treatment study of direct-acting antiviral (DAA)-containing regimens.

Detailed Description

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Conditions

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Hepatitis C Virus Infection

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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SOF/VEL/VOX

SOF/VEL/VOX for 12 weeks

Group Type EXPERIMENTAL

SOF/VEL/VOX

Intervention Type DRUG

400/100/100 mg FDC tablet administered orally once daily with food

Interventions

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SOF/VEL/VOX

400/100/100 mg FDC tablet administered orally once daily with food

Intervention Type DRUG

Other Intervention Names

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GS-7997/GS-5816/GS-9857 Vosevi®

Eligibility Criteria

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Inclusion Criteria

* Chronically HCV-infected males and non-pregnant/non-lactating females aged 18 years or older who did not achieve sustained virologic response (SVR) in a prior Gilead-sponsored HCV treatment study
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Gilead Sciences

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Gilead Study Director

Role: STUDY_DIRECTOR

Gilead Sciences

Locations

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Ruane Clinical Research Group Inc.

Los Angeles, California, United States

Site Status

Cedars Sinai Medical Center

Los Angeles, California, United States

Site Status

Stanford Hospital and Clinics

Palo Alto, California, United States

Site Status

Inland Empire Liver Foundation

Rialto, California, United States

Site Status

Kaiser Permanente

San Diego, California, United States

Site Status

University of Colorado Denver (Leprino Building)

Aurora, Colorado, United States

Site Status

Orlando Immunology Center

Orlando, Florida, United States

Site Status

Emory Hospital Midtown Infectious Disease Clinic

Atlanta, Georgia, United States

Site Status

Gastrointestinal Specialists of Georgia

Marietta, Georgia, United States

Site Status

Saint Louis University, Gastroenterology & Hepatology, Clinical Research Unit

St Louis, Missouri, United States

Site Status

NYU Langone Medical Center

New York, New York, United States

Site Status

Columbia University Medical Center/ New York Presbyterian

New York, New York, United States

Site Status

Center for Liver Diseases, Oakland

Pittsburgh, Pennsylvania, United States

Site Status

University Gastroenterology

Providence, Rhode Island, United States

Site Status

Gastro One

Germantown, Tennessee, United States

Site Status

New Orleans Center for Clinical Research

Knoxville, Tennessee, United States

Site Status

University of Washington/Harborview Medical Center

Seattle, Washington, United States

Site Status

Royal Prince Alfred Hospital

Camperdown, New South Wales, Australia

Site Status

Translational Research Centre

Darlinghurst, New South Wales, Australia

Site Status

Kay Edmonton Clinic

Edmonton, , Canada

Site Status

Toronto Centre for Liver Disease (TCLD), Toronto General Hospital

Toronto, , Canada

Site Status

Centre Hospitalier Universitaire de Rouen

Rouen, , France

Site Status

Leber- and Studienzentrum am Checkpoint

Berlin, , Germany

Site Status

Universitatsklinikum Bonn

Bonn, , Germany

Site Status

Auckland Clinical Studies Ltd

Grafton, Auckland, New Zealand

Site Status

Christchurch Clinical Studies Trust, Ltd

Christchurch, , New Zealand

Site Status

Kings College Hospital NHS Trust

London, , United Kingdom

Site Status

Countries

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United States Australia Canada France Germany New Zealand United Kingdom

References

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Ruane P, Strasser SJ, Gane EJ, Hyland RH, Shao J, Dvory-Sobol H, et al. Retreatment with Sofosbuvir/Velpatasvir/Voxilaprevir for 12 weeks is safe and effective for patients who have previously received Sofosbuvir/Velpatasvir or Sofosbuvir/Velpatasvir/Voxilaprevir [Abstract LBO-06]. 16th International Symposium on Viral Hepatitis and Liver Diseases (ISVHLD); 2018 14-17 June; Toronto, Canada

Reference Type RESULT

Provided Documents

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Document Type: Study Protocol

View Document

Document Type: Statistical Analysis Plan

View Document

Other Identifiers

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2017-000179-98

Identifier Type: EUDRACT_NUMBER

Identifier Source: secondary_id

GS-US-367-4181

Identifier Type: -

Identifier Source: org_study_id

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