Zero-fluoroscopic Navigation Versus Conventional Fluoroscopic Navigation for Single-chamber Pacemaker Implantation

NCT ID: NCT03118440

Last Updated: 2017-04-18

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

100 participants

Study Classification

INTERVENTIONAL

Study Start Date

2013-01-31

Study Completion Date

2020-12-31

Brief Summary

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This study is intended to compare the feasibility, safety and efficacy of Ensite-NavX zero-fluoroscopic navigation system to conventional fluoroscopic X-ray approach as to performing single-chamber pacemaker implantation.

Detailed Description

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Permanent pacemaker is a well-established treatment to treat patients with a wide range of heart rhythm disturbances.

Fluoroscopy is the imaging modality routinely used for cardiac device implantation and electrophysiological procedures.Due to the rising concern regarding the harmful effects of radiation exposure to both the patients and operation staffs, novel 3D mapping systems have been developed and implemented in electrophysiological procedure for the navigation of catheters inside the heart chambers.

Ensite NavX system can be used for cardiac imaging as a reliable and safe zero-fluoroscopy approach for implantation of single- or dual-chamber permanent pacemaker in patients. Our method offered a choice for some special population of patient in whom radiation exposure need to be avoided or in the extreme circumstances when the X-ray machine is out-of-order.

Conditions

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Sick Sinus Syndrome Complete Atrioventricular Block High Degree Second Degree Atrioventricular Block Bradycardia

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

SINGLE

Participants

Study Groups

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Zero-fluoroscopy implantation

Pacemaker implantation performed for all patients in this group with zero-fluoroscopy 3D navigation.

Group Type EXPERIMENTAL

zero-fluoroscopy 3D navigation

Intervention Type PROCEDURE

Pacemaker implantation will be performed without fluoroscopy using 3D navigation systems.

Conventional fluoroscopy implantation

Pacemaker implantation performed for all patients with conventional x-ray navigation.

Group Type ACTIVE_COMPARATOR

conventional x-ray navigation

Intervention Type PROCEDURE

Pacemaker implantation will be performed with fluoroscopy using conventional X-ray navigation.

Interventions

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zero-fluoroscopy 3D navigation

Pacemaker implantation will be performed without fluoroscopy using 3D navigation systems.

Intervention Type PROCEDURE

conventional x-ray navigation

Pacemaker implantation will be performed with fluoroscopy using conventional X-ray navigation.

Intervention Type PROCEDURE

Other Intervention Names

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non-fluoroscopy 3D navigation fluoroscopy navigation

Eligibility Criteria

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Inclusion Criteria

* Sick Sinus Syndrome
* complete Atrioventricular Block
* high degree second Degree Atrioventricular Block
* Bradycardia

Exclusion Criteria

* pacemaker replacement
* severe structural l cardiac malformations
* severe cardiac enlargement
* venous malformations
Minimum Eligible Age

18 Years

Maximum Eligible Age

90 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Fu Wai Hospital, Beijing, China

OTHER

Sponsor Role collaborator

Xinyang Central Hospital

OTHER

Sponsor Role collaborator

First Affiliated Hospital of Guangxi Medical University

OTHER

Sponsor Role collaborator

Guangdong Provincial People's Hospital

OTHER

Sponsor Role collaborator

Wuhan Asia Heart Hospital

OTHER

Sponsor Role collaborator

Shenzhen Sun Yat-sen Cardiovascular Hospital

OTHER

Sponsor Role collaborator

Ningbo No. 1 Hospital

OTHER

Sponsor Role collaborator

Tongji Hospital

OTHER

Sponsor Role lead

Responsible Party

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Yan Wang

Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Yan Wang, PhD

Role: PRINCIPAL_INVESTIGATOR

Tongji Hospital

Locations

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Tongji Hospital

Wuhan, Hubei, China

Site Status RECRUITING

Countries

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China

Central Contacts

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Yan Wang, PhD

Role: CONTACT

86-027-83663280

Guangzhi Chen, PhD

Role: CONTACT

86-027-83662842

Facility Contacts

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Yan Wang, PhD

Role: primary

86-13697326307

Guangzhi Chen, PhD

Role: backup

86-027-83662842

References

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Miller DL, Balter S, Schueler BA, Wagner LK, Strauss KJ, Vano E. Clinical radiation management for fluoroscopically guided interventional procedures. Radiology. 2010 Nov;257(2):321-32. doi: 10.1148/radiol.10091269.

Reference Type BACKGROUND
PMID: 20959547 (View on PubMed)

Ventura R, Rostock T, Klemm HU, Lutomsky B, Demir C, Weiss C, Meinertz T, Willems S. Catheter ablation of common-type atrial flutter guided by three-dimensional right atrial geometry reconstruction and catheter tracking using cutaneous patches: a randomized prospective study. J Cardiovasc Electrophysiol. 2004 Oct;15(10):1157-61. doi: 10.1046/j.1540-8167.2004.04064.x.

Reference Type BACKGROUND
PMID: 15485440 (View on PubMed)

Gepstein L, Hayam G, Ben-Haim SA. A novel method for nonfluoroscopic catheter-based electroanatomical mapping of the heart. In vitro and in vivo accuracy results. Circulation. 1997 Mar 18;95(6):1611-22. doi: 10.1161/01.cir.95.6.1611.

Reference Type BACKGROUND
PMID: 9118532 (View on PubMed)

Lemery R. Interventional electrophysiology at the crossroads: cardiac mapping, ablation and pacing without fluoroscopy. J Cardiovasc Electrophysiol. 2012 Oct;23(10):1087-91. doi: 10.1111/j.1540-8167.2012.02373.x. Epub 2012 Aug 6. No abstract available.

Reference Type BACKGROUND
PMID: 22882722 (View on PubMed)

Richter S, Doring M, Gaspar T, John S, Rolf S, Sommer P, Hindricks G, Piorkowski C. Cardiac resynchronization therapy device implantation using a new sensor-based navigation system: results from the first human use study. Circ Arrhythm Electrophysiol. 2013 Oct;6(5):917-23. doi: 10.1161/CIRCEP.113.000066. Epub 2013 Sep 3.

Reference Type BACKGROUND
PMID: 24002003 (View on PubMed)

Wittkampf FH, Wever EF, Derksen R, Wilde AA, Ramanna H, Hauer RN, Robles de Medina EO. LocaLisa: new technique for real-time 3-dimensional localization of regular intracardiac electrodes. Circulation. 1999 Mar 16;99(10):1312-7. doi: 10.1161/01.cir.99.10.1312.

Reference Type BACKGROUND
PMID: 10077514 (View on PubMed)

Schreieck J, Ndrepepa G, Zrenner B, Schneider MA, Weyerbrock S, Dong J, Schmitt C. Radiofrequency ablation of cardiac arrhythmias using a three-dimensional real-time position management and mapping system. Pacing Clin Electrophysiol. 2002 Dec;25(12):1699-707. doi: 10.1046/j.1460-9592.2002.01699.x.

Reference Type BACKGROUND
PMID: 12520670 (View on PubMed)

Other Identifiers

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TJHCDC-ZF-PMSC-20130101

Identifier Type: -

Identifier Source: org_study_id

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