A Study Comparing Upadacitinib (ABT-494) to Placebo in Participants With Active Psoriatic Arthritis Who Have a History of Inadequate Response to at Least One Biologic Disease Modifying Anti-Rheumatic Drug

NCT ID: NCT03104374

Last Updated: 2025-09-11

Study Results

Results available

Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE3

Total Enrollment

642 participants

Study Classification

INTERVENTIONAL

Study Start Date

2017-05-01

Study Completion Date

2024-09-30

Brief Summary

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This is a Phase 3 multicenter study that included two periods. Period 1 was designed to compare the safety, tolerability, and efficacy of upadacitinib 15 mg once daily (QD) and 30 mg QD versus placebo in participants with moderately to severely active Psoriatic Arthritis (PsA) who had an inadequate response to Biological Disease Modifying Anti-Rheumatic Drug (bDMARDs). Period 2 evaluated the safety, tolerability and efficacy of upadacitinib 15 mg QD and 30 mg QD in subjects with PsA who completed Period 1.

Detailed Description

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The study included a 35-day screening period; a 56-week blinded period which included 24 weeks of randomized, double-blind, parallel-group, placebo-controlled treatment followed by an additional 32 weeks of treatment blinded to the dose of upadacitinib (Period 1); a long-term extension period of up to a total treatment duration of up to approximately 3 years (Period 2); and a 30-day follow-up call or visit.

All participants in Period 1 who were randomized to receive Placebo up to 24 weeks were pooled for the assessment of all outcome measures. All participants receiving upadacitinib 30 mg QD during Period 2 were switched to upadacitinib 15 mg QD following a protocol amendment and were pooled for AE reporting.

Conditions

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Psoriatic Arthritis

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

QUADRUPLE

Participants Caregivers Investigators Outcome Assessors

Study Groups

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Upadacitinib 15 mg

Administered once daily.

Group Type EXPERIMENTAL

Upadacitinib

Intervention Type DRUG

Oral tablet

Placebo / Upadacitinib 30 mg

Administered once daily.

Group Type PLACEBO_COMPARATOR

Placebo

Intervention Type DRUG

Oral tablet

Upadacitinib

Intervention Type DRUG

Oral tablet

Upadacitinib 30 mg

Administered once daily.

Group Type EXPERIMENTAL

Upadacitinib

Intervention Type DRUG

Oral tablet

Placebo / Upadacitinib 15 mg

Administered once daily.

Group Type PLACEBO_COMPARATOR

Placebo

Intervention Type DRUG

Oral tablet

Upadacitinib

Intervention Type DRUG

Oral tablet

Interventions

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Placebo

Oral tablet

Intervention Type DRUG

Upadacitinib

Oral tablet

Intervention Type DRUG

Other Intervention Names

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ABT-494

Eligibility Criteria

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Inclusion Criteria

* Clinical diagnosis of PsA with symptom onset at least 6 months prior to the Screening Visit and fulfillment of the Classification Criteria for PsA (CASPAR) criteria
* Participant has active disease at Baseline defined as \>= 3 tender joints (based on 68 joint counts) and \>= 3 swollen joints (based on 66 joint counts) at Screening and Baseline Visits
* Diagnosis of active plaque psoriasis or documented history of plaque psoriasis
* Participant has had an inadequate response (lack of efficacy after a minimum 12 week duration of therapy) or intolerance to treatment with at least 1 bDMARD.

Exclusion Criteria

* Prior exposure to any Janus Kinase (JAK) inhibitor (including but not limited to ruxolitinib, tofacitinib, baricitinib, and filgotinib)
* Current treatment with \> 2 non-biologic DMARDs or use of DMARDs other than Methotrexate (MTX), Sulfasalazine (SSZ), Leflunomide (LEF), apremilast, Hydroxychloroquine (HCQ), bucillamine or iguratimod or use of MTX in combination with LEF at Baseline.
* History of fibromyalgia, any arthritis with onset prior to age 17 years, or current diagnosis of inflammatory joint disease other than PsA (including, but not limited to rheumatoid arthritis, gout, overlap connective tissue diseases, scleroderma, polymyositis, dermatomyositis, systemic lupus erythematosus). Prior history of reactive arthritis or axial spondyloarthritis including ankylosing spondylitis and non-radiographic axial spondyloarthritis is permitted if documentation of change in diagnosis to PsA or additional diagnosis of PsA is made. Prior history of fibromyalgia is permitted if documentation of change in diagnosis to PsA or documentation that the diagnosis of fibromyalgia was made incorrectly.
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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AbbVie

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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ABBVIE INC.

Role: STUDY_DIRECTOR

AbbVie

Locations

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Alabama Medical Group, PC /ID# 159836

Mobile, Alabama, United States

Site Status

Arizona Arthritis & Rheumatology Research, PLLC /ID# 160047

Mesa, Arizona, United States

Site Status

Sun Valley Arthritis Center Ltd. /ID# 161203

Peoria, Arizona, United States

Site Status

Duplicate_AZ Arthritis and Rheumotology Research, PLLC /ID# 160006

Phoenix, Arizona, United States

Site Status

Osteoporosis Medical Center /ID# 161411

Beverly Hills, California, United States

Site Status

Covina Arthritis Clinic /ID# 159919

Covina, California, United States

Site Status

Triwest Research Associates /ID# 159915

El Cajon, California, United States

Site Status

Duplicate_Providence Medical Foundation /ID# 160005

Fullerton, California, United States

Site Status

C.V. Mehta MD, Med Corporation /ID# 161192

Hemet, California, United States

Site Status

Care Access Research, Huntington Beach /ID# 160049

Huntington Beach, California, United States

Site Status

Purushotham & Akther Kotha MD, Inc /ID# 159834

La Mesa, California, United States

Site Status

Stanford University School of Med /ID# 161402

Stanford, California, United States

Site Status

Inland Rheum Clin Trials Inc. /ID# 159839

Upland, California, United States

Site Status

Medvin Clinical Research /ID# 160045

Whittier, California, United States

Site Status

Denver Arthritis Clinic /ID# 159899

Denver, Colorado, United States

Site Status

Colorado Arthritis Associates /ID# 159856

Lakewood, Colorado, United States

Site Status

Duplicate_Arthritis & Rheumatic Disease Specialties /ID# 161409

Aventura, Florida, United States

Site Status

International Medical Research /ID# 160051

Daytona Beach, Florida, United States

Site Status

Precision Research Organization /ID# 161293

Miami Lakes, Florida, United States

Site Status

Duplicate_Suncoast Clinical Research /ID# 161417

New Port Richey, Florida, United States

Site Status

Millennium Research /ID# 159833

Ormond Beach, Florida, United States

Site Status

Arthritis Center, Inc. /ID# 163463

Palm Harbor, Florida, United States

Site Status

Gulf Region Clinical Res Inst /ID# 159860

Pensacola, Florida, United States

Site Status

Sarasota Arthritis Center /ID# 159854

Sarasota, Florida, United States

Site Status

BayCare Medical Group /ID# 161405

St. Petersburg, Florida, United States

Site Status

West Broward Rheumatology Associates /ID# 161412

Tamarac, Florida, United States

Site Status

Clinical Research of West Florida - Tampa /ID# 160069

Tampa, Florida, United States

Site Status

Clinical Research of West Florida, Inc /ID# 159840

Tampa, Florida, United States

Site Status

USF Health Morsani Center for /ID# 161291

Tampa, Florida, United States

Site Status

BayCare Medical Group, Inc. /ID# 159912

Tampa, Florida, United States

Site Status

Florida Medical Clinic /ID# 160013

Zephyrhills, Florida, United States

Site Status

Jefrey D. Lieberman, MD, P.C. /ID# 159842

Decatur, Georgia, United States

Site Status

Atlanta Research Center for Rheumatology /ID# 161201

Marietta, Georgia, United States

Site Status

Velocity Clinical Research - Boise /ID# 159922

Meridian, Idaho, United States

Site Status

Great Lakes Clinical Trials /ID# 163438

Chicago, Illinois, United States

Site Status

Deerbrook Medical Associates /ID# 159815

Libertyville, Illinois, United States

Site Status

Duplicate_Clinic of Robert Hozman/Clinical Investigation Specialists /ID# 160068

Skokie, Illinois, United States

Site Status

The Arthritis & Diabetes Clinic, Inc. /ID# 161294

Monroe, Louisiana, United States

Site Status

Arthritis Treatment Center /ID# 160053

Frederick, Maryland, United States

Site Status

The Center for Rheumatology and Bone Research /ID# 159900

Wheaton, Maryland, United States

Site Status

Clinical Pharmacology Study Group /ID# 158712

Worcester, Massachusetts, United States

Site Status

Clinvest Research LLC /ID# 161208

Springfield, Missouri, United States

Site Status

Westroads Clinical Research /ID# 160004

Omaha, Nebraska, United States

Site Status

Atlantic Coast Research /ID# 159810

Toms River, New Jersey, United States

Site Status

Duplicate_Arthritis and Osteo Assoc /ID# 160015

Las Cruces, New Mexico, United States

Site Status

Center for Rheumatology LLP /ID# 167046

Albany, New York, United States

Site Status

St. Lawrence Health System /ID# 159857

Potsdam, New York, United States

Site Status

DJL Clinical Research, PLLC /ID# 161414

Charlotte, North Carolina, United States

Site Status

Physicians East, PA /ID# 159898

Greenville, North Carolina, United States

Site Status

Shanahan Rheuma & Immuno /ID# 160012

Raleigh, North Carolina, United States

Site Status

PMG Research of Wilmington LLC /ID# 161403

Wilmington, North Carolina, United States

Site Status

Trinity Health Med Arts Clinic /ID# 159811

Minot, North Dakota, United States

Site Status

STAT Research, Inc. /ID# 161416

Vandalia, Ohio, United States

Site Status

Health Research of Oklahoma /ID# 159913

Oklahoma City, Oklahoma, United States

Site Status

Altoona Ctr Clinical Res /ID# 159861

Duncansville, Pennsylvania, United States

Site Status

University of Pittsburgh MC /ID# 161193

Pittsburgh, Pennsylvania, United States

Site Status

Articularis Healthcare Group, Inc d/b/a Low Country Rheumatology /ID# 163462

Summerville, South Carolina, United States

Site Status

Rheumatology Consultants, PLLC /ID# 161408

Knoxville, Tennessee, United States

Site Status

Dr. Ramesh Gupta /ID# 160067

Memphis, Tennessee, United States

Site Status

Tekton Research, Inc. /ID# 160008

Austin, Texas, United States

Site Status

Diagnostic Group /ID# 161406

Beaumont, Texas, United States

Site Status

Arthritis and Osteoporosis Clinic Of Brazos Valley /ID# 163439

College Station, Texas, United States

Site Status

Adriana Pop-Moody MD Clinic PA /ID# 160009

Corpus Christi, Texas, United States

Site Status

Metroplex Clinical Research /ID# 159818

Dallas, Texas, United States

Site Status

Rheumatic Disease Clin Res Ctr /ID# 161252

Houston, Texas, United States

Site Status

Accurate Clinical Research /ID# 160052

Houston, Texas, United States

Site Status

P&I Clinical Research /ID# 159837

Lufkin, Texas, United States

Site Status

SW Rheumatology Res. LLC /ID# 160014

Mesquite, Texas, United States

Site Status

DM Clinical Research - Tomball /ID# 161753

Tomball, Texas, United States

Site Status

Arthritis & Osteoporosis Clinic /ID# 161400

Waco, Texas, United States

Site Status

Arthritis Clinic of N. VA, P.C /ID# 159858

Arlington, Virginia, United States

Site Status

Duplicate_Swedish Medical Center /ID# 159918

Seattle, Washington, United States

Site Status

Emeritus Research Sydney /ID# 166751

Botany, New South Wales, Australia

Site Status

The Queen Elizabeth Hospital /ID# 200840

Woodville South, South Australia, Australia

Site Status

Box Hill Hospital /ID# 166752

Box Hill, Victoria, Australia

Site Status

Heidelberg Repatriation Hospital /ID# 167441

Heidelberg West, Victoria, Australia

Site Status

ReumaClinic /ID# 164214

Genk, Limburg, Belgium

Site Status

UZ Gent /ID# 164210

Ghent, Oost-Vlaanderen, Belgium

Site Status

CIP - Centro Internacional de Pesquisa /ID# 161808

Goiânia, Goiás, Brazil

Site Status

Faculdade de Medicina do ABC /ID# 163489

Santo André, La Spezia, Brazil

Site Status

Hospital de Clínicas da Universidade Federal de Uberlândia /ID# 161794

Uberlândia, Minas Gerais, Brazil

Site Status

Hospital de Clinicas de Porto Alegre /ID# 161795

Porto Alegre, Rio Grande do Sul, Brazil

Site Status

LMK Sevicos Medicos S/S /ID# 161806

Porto Alegre, Rio Grande do Sul, Brazil

Site Status

Duplicate_Hospital das Clinicas da Faculdade de Medicina de Ribeirao Preto - USP /ID# 163317

Ribeirão Preto, São Paulo, Brazil

Site Status

Hospital das Clinicas da Faculdade de Medicina da Universidade de Sao /ID# 161793

São Paulo, , Brazil

Site Status

Percuro Clinical Research, Ltd /ID# 157835

Victoria, British Columbia, Canada

Site Status

CIADS Research Co Ltd /ID# 157843

Winnipeg, Manitoba, Canada

Site Status

The Waterside Clinic /ID# 157838

Orillia, Ontario, Canada

Site Status

Groupe de Recherche en Maladies Osseuses Inc /ID# 157836

Sainte-Foy, Quebec, Canada

Site Status

Centre de Recherche Musculo-Squelettique /ID# 163557

Trois-Rivières, Quebec, Canada

Site Status

CTR Estudios Clinicos /ID# 206038

Providencia, Aysén, Chile

Site Status

Duplicate_Clinica Dermacross /ID# 169537

Santiago, , Chile

Site Status

Duplicate_Centro Internacional de Estudios Clinicos /ID# 169543

Santiago, , Chile

Site Status

Prosalud Ltda. /ID# 169542

Santiago, , Chile

Site Status

Revmatologie Bruntal, s.r.o /ID# 159632

Prostějov, , Czechia

Site Status

Medical Plus, s.r.o. /ID# 159631

Uherské Hradiště, , Czechia

Site Status

Hopital Saint Joseph /ID# 163755

Marseille, Bouches-du-Rhone, France

Site Status

CHU Toulouse /ID# 163743

Toulouse, Occitanie, France

Site Status

Centre Hospitalier du Mans /ID# 163746

Le Mans, Sarthe, France

Site Status

CHRU Tours - Hopital Trousseau /ID# 163772

Chambray-lès-Tours, , France

Site Status

Duplicate_CHU-Hospital Henri Mondor /ID# 163895

Créteil, , France

Site Status

Duplicate_AP-HP - Hopital Lariboisiere /ID# 163773

Paris, , France

Site Status

General Hospital of Athens Laiko /ID# 163474

Athens, Attica, Greece

Site Status

Naval Hospital of Athens /ID# 163495

Athens, , Greece

Site Status

Reg Gen Univ Hosp Larissa /ID# 163493

Larissa, , Greece

Site Status

Gyor-Moson-Sopron Varmegyei Petz Aladar Egyetemi Oktato Korhaz /ID# 162573

Győr, Győr-Moson-Sopron, Hungary

Site Status

Vital Medicina Kft /ID# 162571

Veszprém, Veszprém megye, Hungary

Site Status

Betegapolo Irgalmasrend Budai Irgalmasrendi Korhaz /ID# 170911

Budapest, , Hungary

Site Status

Revita Reumatologiai Rendelo /ID# 162575

Budapest, , Hungary

Site Status

Obudai Egeszsegugyi Centrum Kft. /ID# 162576

Budapest, , Hungary

Site Status

Debreceni Egyetem Kenezy Gyula Egyetemi Korhaz /ID# 162572

Debrecen, , Hungary

Site Status

MÁV Kórház /ID# 162574

Szolnok, , Hungary

Site Status

Azienda Ospedaliera Universitaria Federico II /ID# 202410

Napoli, L Aquila, Italy

Site Status

Duplicate_Fondazione Policlinico Universitario Campus Bio-Medico di Roma /ID# 164123

Rome, Roma, Italy

Site Status

Duplicate_Fondazione PTV Policlinico Tor Vergata /ID# 162749

Rome, Roma, Italy

Site Status

Duplicate_Azienda Ospedaliero Universitaria Ospedali Riuniti di Ancona /ID# 162748

Ancona, , Italy

Site Status

Duplicate_A.O.U. Policlinico G. Rodolico S.Marco- Presidio G.Rodolico /ID# 164126

Catania, , Italy

Site Status

Duplicate_AOU Arcispedale Sant Anna di /ID# 164127

Cona, , Italy

Site Status

ASST Gaetano Pini/Presidio Ospedaliero Pini /ID# 164125

Milan, , Italy

Site Status

Duplicate_Azienda Unita Sanitaria Locale/IRCCS /ID# 162751

Reggio Emilia, , Italy

Site Status

Daido Hospital /ID# 163639

Nagoya, Aichi-ken, Japan

Site Status

Nagoya City University Hospital /ID# 162563

Nagoya, Aichi-ken, Japan

Site Status

Fukuoka University Hospital /ID# 161774

Fukuoka, Fukuoka, Japan

Site Status

Duplicate_Kitakyushu Municipal Medical Center /ID# 163516

Kitakyushu-shi, Fukuoka, Japan

Site Status

Hospital of the University of Occupational and Environmental Health, Japan /ID# 161472

Kitakyushu-shi, Fukuoka, Japan

Site Status

Asahikawa Medical University Hospital /ID# 200684

Asahikawa-shi, Hokkaido, Japan

Site Status

Mie University Hospital /ID# 162085

Tsu, Mie-ken, Japan

Site Status

Tohoku University Hospital /ID# 164035

Sendai, Miyagi, Japan

Site Status

Oribe Clinic of Rheumatism and Medicine /ID# 163704

Ōita, Oita Prefecture, Japan

Site Status

Kansai Medical University Hospital /ID# 162081

Hirakata-shi, Osaka, Japan

Site Status

National Hospital Organization Osaka Minami Medical Center /ID# 162589

Kawachinagano Shi, Osaka, Japan

Site Status

Osaka Metropolitan University Hospital /ID# 162082

Osaka, Osaka, Japan

Site Status

Nippon Life Saiseikai Public Interest Foundation Nippon Life Hospital /ID# 161773

Osaka, Osaka, Japan

Site Status

Juntendo University Hospital /ID# 162089

Bunkyo-ku, Tokyo, Japan

Site Status

St.Luke's International Hospital /ID# 162013

Chuo-ku, Tokyo, Japan

Site Status

Keio University Hospital /ID# 162130

Shinjuku-ku, Tokyo, Japan

Site Status

Medisch Centrum Leeuwarden /ID# 163049

Leeuwarden, South Holland, Netherlands

Site Status

Duplicate_Erasmus Medisch Centrum /ID# 163052

Rotterdam, South Holland, Netherlands

Site Status

Maasstad Ziekenhuis /ID# 163050

Rotterdam, South Holland, Netherlands

Site Status

Sint Maartenskliniek /ID# 163703

Ubbergen, , Netherlands

Site Status

Duplicate_Middlemore Hospital /ID# 166411

Otahuhu, Auckland, New Zealand

Site Status

Timaru Medical Specialists Ltd /ID# 166410

Timaru, Canterbury, New Zealand

Site Status

Waikato Hospital /ID# 166412

Hamilton, Waikato Region, New Zealand

Site Status

Porter Rheumatology Ltd /ID# 200422

Nelson, , New Zealand

Site Status

Duplicate_Centro Hospitalar de Vila Nova de Gaia/Espinho, EPE /ID# 165897

Vila Nova de Gaia, Porto District, Portugal

Site Status

Unidade Local de Saúde do Alto Minho, EPE - Hospital Conde de Bertiandos /ID# 165898

Ponte de Lima, Viana do Castelo District, Portugal

Site Status

Instituto Portugues De Reumatologia /ID# 165894

Lisbon, , Portugal

Site Status

Centro Hospitalar de Lisboa Ocidental, EPE - Hospital Egas Moniz /ID# 165896

Lisbon, , Portugal

Site Status

Unidade Local de Saude de Santa Maria, EPE /ID# 165895

Lisbon, , Portugal

Site Status

Alma M. Cruz Santana, MD-Private practice /ID# 163308

Carolina, , Puerto Rico

Site Status

Ponce Medical School Foundation /ID# 163918

Ponce, , Puerto Rico

Site Status

GCM Medical Group PSC /ID# 163716

San Juan, , Puerto Rico

Site Status

Duplicate_Ajou University Hospital /ID# 163893

Suwon, Gyeonggido, South Korea

Site Status

Duplicate_Inha University Hospital /ID# 163892

Junggu, Incheon Gwang Yeogsi, South Korea

Site Status

Hospital Clinico Universitario Virgen de la Arrixaca /ID# 163138

El Palmar, Murcia, Spain

Site Status

Duplicate_Hospital Universitario A Coruna - CHUAC /ID# 161019

A Coruña, , Spain

Site Status

Duplicate_Hospital Universitario Reina Sofia /ID# 170764

Córdoba, , Spain

Site Status

Hospital Campus de la Salud /ID# 170768

Granada, , Spain

Site Status

Hospital Universitario Ramon y Cajal /ID# 161020

Madrid, , Spain

Site Status

Royal United Hospitals Bath /ID# 161054

Bath, Bath And North East Somerset, United Kingdom

Site Status

Barts Health NHS Trust /ID# 161053

London, London, City of, United Kingdom

Site Status

Guys and St Thomas NHS Foundation Trust /ID# 161063

London, London, City of, United Kingdom

Site Status

Duplicate_NHS Greater Glasgow and Clyde /ID# 162712

Glasgow, , United Kingdom

Site Status

Duplicate_Bedfordshire Hospitals NHS Foundation Trust /ID# 162713

Luton, , United Kingdom

Site Status

Duplicate_Christchurch University Hospitals Dorset NHS University Hospitals Dors /ID# 162711

Poole, , United Kingdom

Site Status

Countries

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United States Australia Belgium Brazil Canada Chile Czechia France Greece Hungary Italy Japan Netherlands New Zealand Portugal Puerto Rico South Korea Spain United Kingdom

References

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Burmester GR, Deodhar A, Irvine AD, Panaccione R, Winthrop KL, Vleugels RA, Levy G, Suravaram S, Palac H, Wegrzyn L, Ford S, Meerwein S, Guttman-Yassky E. Safety Profile of Upadacitinib: Descriptive Analysis in Over 27,000 Patient-Years Across Rheumatoid Arthritis, Psoriatic Arthritis, Axial Spondyloarthritis, Atopic Dermatitis, and Inflammatory Bowel Disease. Adv Ther. 2025 Oct;42(10):5215-5237. doi: 10.1007/s12325-025-03328-y. Epub 2025 Aug 28.

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Burmester GR, Stigler J, Rubbert-Roth A, Tanaka Y, Azevedo VF, Coombs D, Lagunes I, Lippe R, Wung P, Gensler LS. Safety Profile of Upadacitinib up to 5 Years in Psoriatic Arthritis, Ankylosing Spondylitis, and Non-radiographic Axial Spondyloarthritis: An Integrated Analysis of Clinical Trials. Rheumatol Ther. 2024 Jun;11(3):737-753. doi: 10.1007/s40744-024-00671-4. Epub 2024 Apr 29.

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PMID: 38683479 (View on PubMed)

Cantini F, Marchesoni A, Novelli L, Gualberti G, Marando F, McDearmon-Blondell EL, Gao T, McGonagle D, Salvarani C. Effects of upadacitinib on enthesitis in patients with psoriatic arthritis: a post hoc analysis of SELECT-PsA 1 and 2 trials. Rheumatology (Oxford). 2024 Nov 1;63(11):3146-3154. doi: 10.1093/rheumatology/keae057.

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Rubbert-Roth A, Kakehasi AM, Takeuchi T, Schmalzing M, Palac H, Coombs D, Liu J, Anyanwu SI, Lippe R, Curtis JR. Malignancy in the Upadacitinib Clinical Trials for Rheumatoid Arthritis, Psoriatic Arthritis, Ankylosing Spondylitis, and Non-radiographic Axial Spondyloarthritis. Rheumatol Ther. 2024 Feb;11(1):97-112. doi: 10.1007/s40744-023-00621-6. Epub 2023 Nov 20.

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Charles-Schoeman C, Choy E, McInnes IB, Mysler E, Nash P, Yamaoka K, Lippe R, Khan N, Shmagel AK, Palac H, Suboticki J, Curtis JR. MACE and VTE across upadacitinib clinical trial programmes in rheumatoid arthritis, psoriatic arthritis and ankylosing spondylitis. RMD Open. 2023 Nov;9(4):e003392. doi: 10.1136/rmdopen-2023-003392.

Reference Type DERIVED
PMID: 37945286 (View on PubMed)

Mease P, Setty A, Papp K, Van den Bosch F, Tsuji S, Keiserman M, Carter K, Li Y, McCaskill R, McDearmon-Blondell E, Wung P, Tillett W. Upadacitinib in patients with psoriatic arthritis and inadequate response to biologics: 3-year results from the open-label extension of the randomised controlled phase 3 SELECT-PsA 2 study. Clin Exp Rheumatol. 2023 Nov;41(11):2286-2297. doi: 10.55563/clinexprheumatol/8l7bbk. Epub 2023 Jul 5.

Reference Type DERIVED
PMID: 37404160 (View on PubMed)

Burmester GR, Cohen SB, Winthrop KL, Nash P, Irvine AD, Deodhar A, Mysler E, Tanaka Y, Liu J, Lacerda AP, Palac H, Shaw T, Mease PJ, Guttman-Yassky E. Safety profile of upadacitinib over 15 000 patient-years across rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis and atopic dermatitis. RMD Open. 2023 Feb;9(1):e002735. doi: 10.1136/rmdopen-2022-002735.

Reference Type DERIVED
PMID: 36754548 (View on PubMed)

Mease P, Kavanaugh A, Gladman D, FitzGerald O, Soriano ER, Nash P, Feng D, Lertratanakul A, Douglas K, Lippe R, Gossec L. Disease Control with Upadacitinib in Patients with Psoriatic Arthritis: A Post Hoc Analysis of the Randomized, Placebo-Controlled SELECT-PsA 1 and 2 Phase 3 Trials. Rheumatol Ther. 2022 Aug;9(4):1181-1191. doi: 10.1007/s40744-022-00449-6. Epub 2022 May 23.

Reference Type DERIVED
PMID: 35606663 (View on PubMed)

Burmester GR, Winthrop K, Blanco R, Nash P, Goupille P, Azevedo VF, Salvarani C, Rubbert-Roth A, Lesser E, Lippe R, Lertratanakul A, Mccaskill RM, Liu J, Ruderman EM. Safety Profile of Upadacitinib up to 3 Years in Psoriatic Arthritis: An Integrated Analysis of Two Pivotal Phase 3 Trials. Rheumatol Ther. 2022 Apr;9(2):521-539. doi: 10.1007/s40744-021-00410-z. Epub 2021 Dec 30.

Reference Type DERIVED
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Nash P, Richette P, Gossec L, Marchesoni A, Ritchlin C, Kato K, McDearmon-Blondell EL, Lesser E, McCaskill R, Feng D, Anderson JK, Ruderman EM. Upadacitinib as monotherapy and in combination with non-biologic disease-modifying antirheumatic drugs for psoriatic arthritis. Rheumatology (Oxford). 2022 Aug 3;61(8):3257-3268. doi: 10.1093/rheumatology/keab905.

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Strand V, Van den Bosch F, Ranza R, Leung YY, Drescher E, Zueger P, Saffore CD, Lertratanakul A, Lippe R, Nash P. Patient-Reported Outcomes in Psoriatic Arthritis Patients with an Inadequate Response to Biologic Disease-Modifying Antirheumatic Drugs: SELECT-PsA 2. Rheumatol Ther. 2021 Dec;8(4):1827-1844. doi: 10.1007/s40744-021-00377-x. Epub 2021 Oct 18.

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Mease PJ, Lertratanakul A, Papp KA, van den Bosch FE, Tsuji S, Dokoupilova E, Keiserman MW, Bu X, Chen L, McCaskill RM, Zueger P, McDearmon-Blondell EL, Pangan AL, Tillett W. Upadacitinib in Patients with Psoriatic Arthritis and Inadequate Response to Biologics: 56-Week Data from the Randomized Controlled Phase 3 SELECT-PsA 2 Study. Rheumatol Ther. 2021 Jun;8(2):903-919. doi: 10.1007/s40744-021-00305-z. Epub 2021 Apr 28.

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Mease PJ, Lertratanakul A, Anderson JK, Papp K, Van den Bosch F, Tsuji S, Dokoupilova E, Keiserman M, Wang X, Zhong S, McCaskill RM, Zueger P, Pangan AL, Tillett W. Upadacitinib for psoriatic arthritis refractory to biologics: SELECT-PsA 2. Ann Rheum Dis. 2021 Mar;80(3):312-320. doi: 10.1136/annrheumdis-2020-218870. Epub 2020 Dec 3.

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Provided Documents

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Document Type: Study Protocol

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Document Type: Statistical Analysis Plan

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Other Identifiers

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2016-004152-30

Identifier Type: EUDRACT_NUMBER

Identifier Source: secondary_id

M15-554

Identifier Type: -

Identifier Source: org_study_id

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