Tongji Maternal and Child Health Cohort

NCT ID: NCT03099837

Last Updated: 2020-08-04

Basic Information

• Recruitment Status: UNKNOWN
• Total Enrollment: 8649 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2013-01-10
• Study Completion Date: 2023-01-10

Brief Summary

This is a population-based study to obtain data for the evaluation of current used recommendations for weight gain during pregnancy released by IOM (2007) and investigate the association between maternal diet and the health outcomes of mother and offspring.

Detailed Description

This is an ongoing population-based prospective cohort study to obtain data for the evaluation of current used recommendations for weight gain during pregnancy released by IOM (2007) and investigate the association between maternal diet and the health outcomes of mother and offspring. 8649 pregnant have been recuited from the first trimester of pregnancy. All datas including the general information, sociodemographic facts, physical exam (body weight, height, blood pressure, etc), laboratory test (hemoglobin, glucose concentration, etc.) and dietary survey (FFQ, 24h food recall) have been collected during the cohort study. Blood sample leftover from the clinical use are remained and stored at -80℃for further measurements. Obstetric characteristics, maternal and perinatal outcomes have been observed and recorded. Growth and development paremeters such as weight, length and head circumference as well as disease information of infants have been collected , feeding pattern and feeding history will be surveyed. All data collected will be used for group analysis only and all private and individual records will be kept secret.

Conditions

Weight Gain; Maternal; Diabetes Mellitus, Affecting Fetus; Diet Habit; Pregnancy Complications; Birth Outcomes; Breast Feeding; Growth and Development

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: PROSPECTIVE

Study Groups

Pregnant mothers

No interventions assigned to this group

infants

No interventions assigned to this group

children

No interventions assigned to this group

Eligibility Criteria

Inclusion Criteria

• Pregnant women attending the first visit (<16 weeks ) at at a maternity clinic in one of these following hospitals in Wuhan, China: HMCHH, CHW,WMCHH,JMCHH.

Intention to visit the maternity clinic regularly in HMCHH or CHW or WMCHH or JMCHH.

• Intention to eventually deliver in HMCHH or CHW or WMCHH.
• The pregnant woman and her husband are Chinese.

Exclusion Criteria

• Pregnant women on chemotherapy.
• Exclude women on certain medications - e.g. psychotropic drugs.
• Exclude women with significant medical conditions e.g. psychosis etc.

• Eligible Sex: FEMALE
• Accepts Healthy Volunteers: No

Sponsors

Maternal and Child Health Hospital of Hubei Province

OTHER

Sponsor Role: collaborator

Wuhan Central Hospital

OTHER

Sponsor Role: collaborator

Wuhan Maternal and Child Health Hospital

UNKNOWN

Sponsor Role: collaborator

Huazhong University of Science and Technology

OTHER

Sponsor Role: lead

Responsible Party

Nianhong Yang

Professor

Responsibility Role: PRINCIPAL_INVESTIGATOR

References

Kong M, Zhong C, Gao Q, Zhou X, Chen R, Xiong G, Hao L, Yang X, Lu Z, Yang N. Association of elevated mid-pregnancy maternal plasma ferritin concentrations and triglyceride concentrations with the risk of gestational diabetes mellitus: A prospective cohort study. Diabetes Metab Res Rev. 2023 Sep;39(6):e3637. doi: 10.1002/dmrr.3637. Epub 2023 Apr 13.

Reference Type: DERIVED

PMID: 36958940 (View on PubMed)

Zhong C, Xiong G, Lin L, Li Q, Chen X, Zhang X, Zhang Y, Xu S, Wang X, Gao D, Wu M, Yang S, Han W, Sun G, Yang X, Hao L, Jin Z, Yang N. The association of maternal vaginal bleeding and progesterone supplementation in early pregnancy with offspring outcomes: a prospective cohort study. BMC Pregnancy Childbirth. 2022 May 5;22(1):390. doi: 10.1186/s12884-022-04711-1.

Reference Type: DERIVED

PMID: 35513779 (View on PubMed)

Li Y, Zhou X, Zhang Y, Zhong C, Huang L, Chen X, Chen R, Wu J, Li Q, Sun G, Yin H, Xiong G, Hao L, Yang N, Yang X. Association of Maternal Dietary Patterns With Birth Weight and the Mediation of Gestational Weight Gain: A Prospective Birth Cohort. Front Nutr. 2021 Nov 26;8:782011. doi: 10.3389/fnut.2021.782011. eCollection 2021.

Reference Type: DERIVED

PMID: 34901129 (View on PubMed)

Xiong T, Wu Y, Huang L, Chen X, Zhang Y, Zhong C, Gao Q, Hong M, Hu X, Yang X, Yang N, Hao L. Association of the maternal serum albumin level with fetal growth and fetal growth restriction in term-born singletons: a prospective cohort study. Fertil Steril. 2022 Feb;117(2):368-375. doi: 10.1016/j.fertnstert.2021.09.016. Epub 2021 Oct 20.

Reference Type: DERIVED

PMID: 34686372 (View on PubMed)

Gao Q, Zhong C, Zhou X, Chen R, Xiong T, Hong M, Li Q, Kong M, Xiong G, Han W, Sun G, Yang X, Yang N, Hao L. Inverse association of total polyphenols and flavonoids intake and the intake from fruits with the risk of gestational diabetes mellitus: A prospective cohort study. Clin Nutr. 2021 Feb;40(2):550-559. doi: 10.1016/j.clnu.2020.05.053. Epub 2020 Jun 13.

Reference Type: DERIVED

PMID: 32593522 (View on PubMed)

Zhou X, Chen R, Zhong C, Wu J, Li X, Li Q, Cui W, Yi N, Xiao M, Yin H, Xiong G, Han W, Hao L, Yang X, Yang N. Fresh fruit intake in pregnancy and association with gestational diabetes mellitus: A prospective cohort study. Nutrition. 2019 Apr;60:129-135. doi: 10.1016/j.nut.2018.09.022. Epub 2018 Oct 24.

Reference Type: DERIVED

PMID: 30572275 (View on PubMed)

Other Identifiers

HuazhongU-2013-02

Identifier Type: -

Identifier Source: org_study_id