Personalized Smoking Cessation Tool Based on Patient Lung CT Image

NCT ID: NCT03087617

Last Updated: 2022-10-05

Study Results

Results available

Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

321 participants

Study Classification

INTERVENTIONAL

Study Start Date

2018-10-03

Study Completion Date

2021-08-23

Brief Summary

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Imbio is developing a Smoking Cessation Report (Report) that includes data analysis from a CT lung cancer screening exam. This randomized controlled (RCT) trial will clinically validate the Report's effectiveness at motivating smokers to call a Quitline.

Detailed Description

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Imbio is developing a Smoking Cessation Report (Report) that includes data analysis from a CT lung cancer screening exam. This randomized controlled (RCT) trial will clinically validate the Report's impact on: (a) Lung screening participants' motivation to make a quit attempt by calling a Quitline, and (b) the effectiveness of a 45-minute telephone smoking cessation counseling session for motivating an actual quit attempt and abstinence. The RCT will enroll approximately 400 randomly selected participants from lung screening programs at HealthPartners and University of Michigan. Participants will be randomly assigned to one of four conditions: 1) Usual Care + quitline phone number (created specifically for the trial and maintained for the length of the trial); 2) Usual Care + Report (Report will list Quitline number) 3) Usual Care + Counseling, or 4) Usual Care + Report + Counseling. Follow up assessment calls will be conducted with participants at three weeks, three months, and six months following the mailing of the report.

Conditions

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Smoking Cessation

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

FACTORIAL

Primary Study Purpose

OTHER

Blinding Strategy

SINGLE

Outcome Assessors
University of Minnesota Office of Measurements Services will administer follow up calls to assess outcomes. Callers will be blinded to the arm to which the patients were assigned.

Study Groups

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Usual Care

Usual Care includes a lung cancer screening CT exam. Following the screen, a radiologist will analyze the CT scan image and send the results to the patient's Primary Care Physician (PCP). If the scan is read as a category 1 or 2 in the Lung Reporting and Data System (Lung-RADS), patients are provided a letter in the mail with their results. If the scan is read as a category 3, 4A, 4B, or 4X in Lung-RADS the patient will be contacted by their primary care physician's office and told to schedule a follow up appointment. Either in the letter or at the follow up appointment, patients will be given a Quitline number created specifically for this trial and maintained for the duration.

Group Type ACTIVE_COMPARATOR

Usual Care

Intervention Type OTHER

Usual Care for Lung Cancer Screening patients.

Usual Care + Imbio Smoking Cessation Report

In this arm, patients will receive the Usual Care described above and will additionally be provided with the Report. In this arm, the Report will provide the Quitline number.

Group Type EXPERIMENTAL

Imbio Smoking Cessation Report

Intervention Type DEVICE

Research coordinators at the University of Michigan and HealthPartners will be provided access to the research version of LDA via an Imbio website. Following consent and lung screen, research coordinators will manually upload the study participants' images and download a resulting Report. Radiologists have been designated at both sites to review and approve the Report prior to mailing to participants. The Report will include information including the percent of damaged lung volume.

Usual Care

Intervention Type OTHER

Usual Care for Lung Cancer Screening patients.

Usual Care + Counseling

In addition to the Usual Care described above, patients in this arm will participate in a 45 minute smoking cessation counseling session. Approximately three Tobacco Treatment Specialists will be trained to ensure consistent counseling methodology. Counselors will utilize a patient centered approach grounded in Motivational Interviewing skills to elicit perceived benefits for stopping smoking and to enhance self-efficacy for stopping. A major emphasis of a call is to enroll the caller in formal cessation programs and/or convince them to use FDA approved medication as part of a quit attempt. Study participants who desire further smoking cessation support after their session will be connected with the appropriate organization.

Group Type ACTIVE_COMPARATOR

Smoking Cessation Counseling

Intervention Type BEHAVIORAL

45 minute counseling session with a tobacco treatment specialist.

Usual Care

Intervention Type OTHER

Usual Care for Lung Cancer Screening patients.

Usual Care + Imbio Smoking Cessation Report + Counseling

In addition to the Usual Care and Counseling described above, patients in this arm will also receive the Report.

Group Type EXPERIMENTAL

Imbio Smoking Cessation Report

Intervention Type DEVICE

Research coordinators at the University of Michigan and HealthPartners will be provided access to the research version of LDA via an Imbio website. Following consent and lung screen, research coordinators will manually upload the study participants' images and download a resulting Report. Radiologists have been designated at both sites to review and approve the Report prior to mailing to participants. The Report will include information including the percent of damaged lung volume.

Smoking Cessation Counseling

Intervention Type BEHAVIORAL

45 minute counseling session with a tobacco treatment specialist.

Usual Care

Intervention Type OTHER

Usual Care for Lung Cancer Screening patients.

Interventions

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Imbio Smoking Cessation Report

Research coordinators at the University of Michigan and HealthPartners will be provided access to the research version of LDA via an Imbio website. Following consent and lung screen, research coordinators will manually upload the study participants' images and download a resulting Report. Radiologists have been designated at both sites to review and approve the Report prior to mailing to participants. The Report will include information including the percent of damaged lung volume.

Intervention Type DEVICE

Smoking Cessation Counseling

45 minute counseling session with a tobacco treatment specialist.

Intervention Type BEHAVIORAL

Usual Care

Usual Care for Lung Cancer Screening patients.

Intervention Type OTHER

Other Intervention Names

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Smoking Cessation Report Report

Eligibility Criteria

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Inclusion Criteria

* 30-pack year smoking history
* currently smoke OR quit within the last 15 years and a category 1 or 2 Lung-RADS scan

Exclusion Criteria

* current use of smoking cessation medications
* scan read as a category 3, 4A, 4B or 4X in Lung-RADS
* unstable medical or psychiatric conditions
* current alcohol or drug use disorder
* past-month suicidal ideation
* past-year suicide attempt
Minimum Eligible Age

55 Years

Maximum Eligible Age

80 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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National Cancer Institute (NCI)

NIH

Sponsor Role collaborator

University of Michigan

OTHER

Sponsor Role collaborator

Mayo Clinic

OTHER

Sponsor Role collaborator

HealthPartners Institute

OTHER

Sponsor Role collaborator

University of Minnesota

OTHER

Sponsor Role collaborator

Imbio

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Health Partners

Minneapolis, Minnesota, United States

Site Status

Countries

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United States

Provided Documents

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Document Type: Study Protocol and Statistical Analysis Plan

View Document

Document Type: Informed Consent Form

View Document

Other Identifiers

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R44CA203050

Identifier Type: NIH

Identifier Source: secondary_id

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R44CA203050

Identifier Type: NIH

Identifier Source: org_study_id

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