Snow Physical Properties and Human Ventilatory Response

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

12 participants

Study Classification

INTERVENTIONAL

Study Start Date

2013-12-01

Study Completion Date

2014-03-09

Brief Summary

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Sufficient oxygenation is critical for completely buried avalanche victims to avoid life-threatening consequences during hypoxic exposure. Snow contains a remarkable capacity to maintain air availability; it was suspected that the snow physical properties affect the development of hypoxia and hypercapnia. The aim of this study was to evaluate the influence of different snow physical properties on the development of hypoxia and hypercapnia in subjects breathing into an artificial air pocket in snow. Twelve male healthy subjects breathed through an airtight face-mask and 40cm tube into an artificial air pocket of 4L. Every subject performed three tests on different days with varying snow characteristics. Symptoms, gas and cardiovascular parameters were monitored up to 30min. Tests were interrupted at SpO2 \<75% (primary endpoint); or due to subjective symptoms like dyspnea, dizziness, and headache (i.e. related to hypercapnia). Snow density was assessed via standard methods and micro-computed tomography (CT) analysis, and permeability and penetration with the snow micro-penetrometer (SMP).

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Detailed Description

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Conditions

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Hypoxic Respiratory Failure Hypercapnic Respiratory Failure Avalanche Burial Snow Physical Properties

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

DOUBLE

Participants Investigators

Study Groups

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Winter snow

First test series breathing in dry snow in winter

Group Type EXPERIMENTAL

Breathing in snow

Intervention Type OTHER

Breathing in snow with different physical properties

Intermediate snow

Second test series breathing in dry/wet snow in intermediate season

Group Type EXPERIMENTAL

Breathing in snow

Intervention Type OTHER

Breathing in snow with different physical properties

Spring snow

Third test series breathing in very wet snow in spring

Group Type EXPERIMENTAL

Breathing in snow

Intervention Type OTHER

Breathing in snow with different physical properties

Interventions

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Breathing in snow

Breathing in snow with different physical properties

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Healthy volunteers with an age above 18yr-old, physically active.
* Volunteers have been informed and have signed consent.

Exclusion Criteria

* Lack of consent.
* Chronic previous illness of the respiratory tract or of the cardiovascular system.
* Acute disease at or immediately prior to the test (eg, flu-like infection, fever of unknown origin).
* Eurac employees.

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes