Role of SWE-change After TIPS in the Prediction of Prognosis After TIPS

NCT ID: NCT03072615

Last Updated: 2017-03-07

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

83 participants

Study Classification

OBSERVATIONAL

Study Start Date

2013-04-01

Study Completion Date

2016-02-29

Brief Summary

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The aim of our prospective multicenter study was to investigate the prognostic value of the acute and long-term changes of liver stiffness in patients receiving a transjugular intrahepatic portosystemic shunt (TIPS).

Detailed Description

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We included 83 patients receiving TIPS for prevention of rebleeding, therapy-refractory ascites or both. Hemodynamic parameters were assessed before TIPS and after TIPS insertion. 16 patients from Freiburg underwent TE immediately before and after TIPS. In 67 patients from Bonn, SWE of liver and spleen, as well as clinical and biochemical parameters were assessed before TIPS, seven days and six weeks after TIPS.

Conditions

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Portal Hypertension Liver Cirrhoses

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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1

receiving TE before and 30 min after TIPS

Stiffness measurement

Intervention Type DIAGNOSTIC_TEST

Transient Elastopgraphy (TE) or Shear-Wave-Elastography

2

receiving SWE before and 7 days, 6 weeks and 3 months after TIPS

Stiffness measurement

Intervention Type DIAGNOSTIC_TEST

Transient Elastopgraphy (TE) or Shear-Wave-Elastography

Interventions

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Stiffness measurement

Transient Elastopgraphy (TE) or Shear-Wave-Elastography

Intervention Type DIAGNOSTIC_TEST

Eligibility Criteria

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Inclusion Criteria

* TIPS insertion and had reliable SWE or TE measurement

Exclusion Criteria

* contraindication for TIPS
* no reliable SWE or TE measurement
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Jonel Trebicka

OTHER

Sponsor Role lead

Responsible Party

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Jonel Trebicka

Prof. Dr.

Responsibility Role SPONSOR_INVESTIGATOR

References

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Jansen C, Moller P, Meyer C, Kolbe CC, Bogs C, Pohlmann A, Schierwagen R, Praktiknjo M, Abdullah Z, Lehmann J, Thomas D, Strassburg CP, Latz E, Mueller S, Rossle M, Trebicka J. Increase in liver stiffness after transjugular intrahepatic portosystemic shunt is associated with inflammation and predicts mortality. Hepatology. 2018 Apr;67(4):1472-1484. doi: 10.1002/hep.29612. Epub 2018 Feb 20.

Reference Type DERIVED
PMID: 29059466 (View on PubMed)

Other Identifiers

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TIPS-SWE

Identifier Type: -

Identifier Source: org_study_id

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