The Effect of Dexamethasone Added to Bupivacain in Nasal Surgery

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE4

Total Enrollment

60 participants

Study Classification

INTERVENTIONAL

Study Start Date

2017-03-15

Study Completion Date

2017-05-15

Brief Summary

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Nasal packing is frequently applied after nasal surgery. Nasal packing reduces epistaxis, prevents septal hematoma and stabilizes nasal septum. Nasal mucosa is quite sensitive to pain, therefore the most common problems after surgery are postoperative pain and anxiety during removal of the nasal packing. Lots of methods have been tried to control this pain (non-steroidal anti-inflammatory drugs, nerve blockade with long-acting local anesthetics, local anesthetics infiltration into nasal packing).

Glucocorticoids have been used as an adjuvant in the management of acute postoperative pain. Perineural dexamethasone as an adjuvant for the single-injection nerve block can prolong analgesia and reduce opioid-requiring after surgery. Furthermore dexamethasone reduces postoperative nausea and vomiting incidance.

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Detailed Description

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Conditions

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Nasal Surgery

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

SINGLE

Investigators

Study Groups

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Group Bupivacaine

4 ml %0.5 bupivacaine and 1 ml %0.9 NaCl infiltration into nasal packing to both sides

Group Type ACTIVE_COMPARATOR

Bupivacaine

Intervention Type DRUG

%0.5 bupivacaine

Group Bupivacaine+Dexamethasone

4 ml %0.5 bupivacaine and 4mg(1 ml) dexamethasone infiltration into nasal packing to both sides

Group Type ACTIVE_COMPARATOR

Bupivacaine

Intervention Type DRUG

%0.5 bupivacaine

Dexamethasone

Intervention Type DRUG

8 mg Dexamethasone

Interventions

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Bupivacaine

%0.5 bupivacaine

Intervention Type DRUG

Dexamethasone

8 mg Dexamethasone

Intervention Type DRUG

Other Intervention Names

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Bupivacaine only Bupivacaine plus dexamethasone

Eligibility Criteria

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Inclusion Criteria

* American Society of Anesthesiologist's physiologic state I-II patients undergoing nasal surgery

Exclusion Criteria

* chronic pain
* bleeding disorders
* renal or hepatic insufficiency
* patients on chronic non-steroidal anti-inflammatory medications
* emergency cases

Minimum Eligible Age

18 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No