Comparison of the Perioperative Effects of Dexmedetomidine and Ketamine Sedation in Septorhinoplasty Operations
NCT ID: NCT04628559
Last Updated: 2020-11-17
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
63 participants
INTERVENTIONAL
2009-07-01
2009-12-31
Brief Summary
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The groups were compared in terms of hemodynamic values, recovery times, postoperative agitation, sedation, activity, modified Aldrete and pain scores, side-effects and additional analgesia requirements at postoperative 24h.
Detailed Description
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Conditions
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Keywords
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Study Design
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RANDOMIZED
PARALLEL
2. Second arm received ketamine
3. Third arm received saline solution.
TREATMENT
TRIPLE
Study Groups
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Dexmedetomine
Patients recieving Dexmedetomidine.
Dexmedetomidine
dexmedetomidine was administered as a gradual bolus of 1 µg/kg/10ml 10 min before induction of anesthesia and then as an infusion of 0.4 µg/kg per min (30 ml/h). In Group K, ketamine was administered as a 0.4 mg/kg/10ml IV bolus 10 min before induction of anesthesia and in the form of 10 µg/kg per min infusion after induction (30 ml/h).
Ketamine
Patients recieving Ketamine.
Ketamine
In Group K, ketamine was administered as a 0.4 mg/kg/10ml IV bolus 10 min before induction of anesthesia and in the form of 10 µg/kg per min infusion after induction (30 ml/h).
Placebo
Patients recieving Saline.
Saline
Group S was given a bolus of saline solution in 10 ml volume 10 min before induction of anesthesia, followed by 30 mL/h serum saline infusion.
Interventions
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Dexmedetomidine
dexmedetomidine was administered as a gradual bolus of 1 µg/kg/10ml 10 min before induction of anesthesia and then as an infusion of 0.4 µg/kg per min (30 ml/h). In Group K, ketamine was administered as a 0.4 mg/kg/10ml IV bolus 10 min before induction of anesthesia and in the form of 10 µg/kg per min infusion after induction (30 ml/h).
Ketamine
In Group K, ketamine was administered as a 0.4 mg/kg/10ml IV bolus 10 min before induction of anesthesia and in the form of 10 µg/kg per min infusion after induction (30 ml/h).
Saline
Group S was given a bolus of saline solution in 10 ml volume 10 min before induction of anesthesia, followed by 30 mL/h serum saline infusion.
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* Patient subjected to septorhineoplasty operation
Exclusion Criteria
* Patient having yypertension,
* Patient having Asthma,
* Patient having neuropsychiatric disease,
* Patient allergy to the study drugs.
18 Years
55 Years
ALL
Yes
Sponsors
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Karadeniz Technical University
OTHER
Responsible Party
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Muge Kosucu
Clinical Associated Professor
Principal Investigators
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Muge Muge, Assoc Prof
Role: STUDY_CHAIR
Medical School of Karadeniz Technical University, Department of Anesthesiology
Locations
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Medical School of Karadeniz Technical University, Department of Anesthesiology
Trabzon, , Turkey (Türkiye)
Countries
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Other Identifiers
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2009/137
Identifier Type: -
Identifier Source: org_study_id