The Anabolic Effects of Estrogen on Skeletal Muscles

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

31 participants

Study Classification

INTERVENTIONAL

Study Start Date

2017-01-01

Study Completion Date

2018-02-15

Brief Summary

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Purpose: to study the effect of estrogen replacement on muscle hypertrophy in response to 12 weeks resistance training in postmenopausal women Hypothesis: Transdermal administration of 17-β estradiol enhance the anabolic effect of resistance training on muscle mass, strength in postmenopausal women Primary outcome: Muscle hypertrophy (muscle CSA, muscle fiber type specific CSA) Secondary outcome: Messenger RiboNucleic Acid (mRNA)(real-time PCR), protein (western blotting), satellite cell proliferation and activation, Strength, functional test, muscle protein synthese.

Design: Two groups of healthy postmenopausal women (½-5 years after menopause) who have not performed regular resistance exercise (\<1 times per week) the last two years. Randomized, controlled intervention study +/- transdermal administration of estrogen (17-β estradiol). Both groups perform 12 weeks of supervised progressive resistance training (3/week) aiming to induce muscle hypertrophy in the legs.

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Detailed Description

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Conditions

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Estrogen Supplementation

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

PREVENTION

Blinding Strategy

TRIPLE

Participants Investigators Outcome Assessors

Study Groups

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Exercise + Estrogen

Strength training 3 times a week for 12 weeks. Estrogen patches which provide 100 um pr. 24 hours.

Group Type EXPERIMENTAL

Exercise + Estrogen

Intervention Type OTHER

12 weeks resistance training and estrogen patches

Exercise + Placebo

Strength training 3 times a week for 12 weeks. Placebo patches.

Group Type ACTIVE_COMPARATOR

Exercise + Placebo

Intervention Type OTHER

12 weeks resistance training and placebo patches

Interventions

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Exercise + Estrogen

12 weeks resistance training and estrogen patches

Intervention Type OTHER

Exercise + Placebo

12 weeks resistance training and placebo patches

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Postmenopausal women, more than 6 months, but less than 5 years since last menstruation.

Exclusion Criteria

* Less than 2 hours exercise with moderate to high intensity per week the last year, no regular resistance exercise the last 2 years (less than 5 exercise bouts during the last year)
* No previous or present lower limb injuries which may hinder participation in strength training
* No use of medicine which may influence the adaptation to strength training such as regular use of nonsteroidal anti-inflammatory drugs and use of statins, no muscle
* Joint or metabolic diseases or other chronic diseases that would affect the results of the investigation, high blood pressure (\>140/90), smoking

Minimum Eligible Age

40 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

Yes