Influences of Long Term Hormone Therapy on Physical Fitness and Vascular Function in Transgender Women

NCT ID: NCT06116201

Last Updated: 2023-11-28

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

60 participants

Study Classification

INTERVENTIONAL

Study Start Date

2020-08-15

Study Completion Date

2021-07-31

Brief Summary

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Transgender women who transitioned from male to female by hormone therapy demonstrate similar physical fitness and vascular function to males or females.

Detailed Description

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This cross-sectional study was to compare physical fitness and vascular function between cisgender men, cisgender women, and transgender women.

Conditions

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Transgender Women

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

SCREENING

Blinding Strategy

NONE

Study Groups

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Transgender women with orchiectomy

Transgender women who took medication for sex transition form male to female via estradiol hormone therapy and orchiectomy surgery. They were recruited for measurement of all variables in the study to compare with another group.

Group Type EXPERIMENTAL

Estradiol

Intervention Type OTHER

Estradiol

Transgender women without orchiectomy

Transgender women who took medication for sex transition form male to female via estradiol hormone and anti-androgen hormone therapy. They were recruited for measurement of all variables in the study to compare with another group.

Group Type EXPERIMENTAL

Estradiol and Anti-Androgen

Intervention Type OTHER

Estradiol and Anti-Androgen

Cisgender men

Cisgender men who lived in normal life were not used medication process for sex transition. They were recruited for measurement of all variables in the study to compare with another group.

Group Type SHAM_COMPARATOR

No intervention

Intervention Type OTHER

No intervention

Cisgender women

Cisgender women who lived in normal life were not used medication process for sex transition. They were recruited for measurement of all variables in the study to compare with another group.

Group Type SHAM_COMPARATOR

No intervention

Intervention Type OTHER

No intervention

Interventions

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Estradiol

Estradiol

Intervention Type OTHER

Estradiol and Anti-Androgen

Estradiol and Anti-Androgen

Intervention Type OTHER

No intervention

No intervention

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

1. Cisgender men group (Body mass index between 18.5-24.9 and NO NCDs).
2. Cisgender women group (Body mass index between 18.5-24.9, No pregnant, NO NCDs).
3. Transgender women with orchiectomy (Body mass index between 18.5-24.9, taking estradiol, testosterone level below 10 nmol/L, NO NCDs).
4. Transgender women without orchiectomy (Body mass index between 18.5-24.9, taking estradiol and anti-androgen, testosterone level below 10 nmol/L, NO NCDs).

Exclusion Criteria

* Participants had an injury during testing.
Minimum Eligible Age

20 Years

Maximum Eligible Age

35 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Chulalongkorn University

OTHER

Sponsor Role lead

Responsible Party

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Prof. Dr.Daroonwan Suksom

Faculty of Sports Science

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Daroonwan Suksom, Ph.D.

Role: STUDY_DIRECTOR

Chulalongkorn University

Locations

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Faculty of Sports Science, Chulalongkorn University

Pathum Wan, Bangkok, Thailand

Site Status

Countries

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Thailand

References

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Saitong A, Naeowong W, Suksom D, Tanaka H. Physical Fitness and Exercise Performance of Transgender Women. Med Sci Sports Exerc. 2025 Jan 1;57(1):134-143. doi: 10.1249/MSS.0000000000003536. Epub 2024 Aug 12.

Reference Type DERIVED
PMID: 39140786 (View on PubMed)

Other Identifiers

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SPSC-7

Identifier Type: -

Identifier Source: org_study_id