Non Invasive Cancer Test (NICT): a Proof of Principle Study.

NCT ID: NCT03019471

Last Updated: 2025-10-07

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

40 participants

Study Classification

OBSERVATIONAL

Study Start Date

2016-03-01

Study Completion Date

2025-12-31

Brief Summary

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The investigators aim to collect tumor DNA out of blood of cancer patients. If this is successful this could lead to the development of a cancer test in blood in the future, which is less invasive than current diagnostic methods.

Detailed Description

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Conditions

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Neoplasmata

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Lung cancer

Isolate Tumor DNA from the patients blood.

Isolation of tumor DNA

Intervention Type GENETIC

Breast cancer

Isolate Tumor DNA from the patients blood.

Isolation of tumor DNA

Intervention Type GENETIC

Colorectal cancer

Isolate Tumor DNA from the patients blood.

Isolation of tumor DNA

Intervention Type GENETIC

Glioma

Isolate Tumor DNA from the patients blood.

Isolation of tumor DNA

Intervention Type GENETIC

Interventions

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Isolation of tumor DNA

Intervention Type GENETIC

Eligibility Criteria

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Inclusion Criteria

1. Patients with newly diagnosed local or metastatic breast cancer, colorectal cancer, non-small cell lung cancer and anaplastic glioblastoma, before start of radiation therapy, chemoradiation or chemotherapy.
2. Patients age \> 18 years, willing and able to comply with the protocol as judged by the investigator with a signed informed consent

Exclusion Criteria

1. Patients with a history of malignant disease other than the disease under study, with an exception for adequately treated squamous cell carcinoma of the skin, basal cell carcinoma of the skin and in situ cervix carcinoma.
2. Pregnancy
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Maastricht University Medical Center

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Christine C. De Die-Smulders, Prof. dr.

Role: PRINCIPAL_INVESTIGATOR

Clinical Geneticist in MUMC+

Locations

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Maastricht University Medical Center

Maastricht, Limburg, Netherlands

Site Status RECRUITING

Countries

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Netherlands

Central Contacts

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Merryn M. Macville, Dr.

Role: CONTACT

+31-43-3875843

Job J. Verdonschot, Drs.

Role: CONTACT

Facility Contacts

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M. Eijck-Vievermans

Role: primary

+313876447

Other Identifiers

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NL55080.068.15

Identifier Type: -

Identifier Source: org_study_id

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