Ketamine vs Hydromorphone

NCT ID: NCT03001843

Last Updated: 2021-03-09

Study Results

Results available

Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE4

Total Enrollment

54 participants

Study Classification

INTERVENTIONAL

Study Start Date

2017-02-22

Study Completion Date

2018-12-21

Brief Summary

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This study will help to determine if investigators can minimize narcotic use in laparoscopic gastric bypass patients while maintaining adequate pain control. This will allow investigators to minimize the negative side effects of narcotics which is a goal in this population.

Detailed Description

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The study will be a head to head observational study of patients who have undergone gastric bypass surgery. The methods of intraoperative anesthesiology will be Ketamine or Narcotic. Both are FDA approved methods of delivering anesthesia.

The amount of narcotics a patient receives is part of the medical record post-operatively will be followed from post-anesthesia care unit (PACU) through to discharge. The amount of narcotics needed to control the patient's pain (converted to morphine equivalent units) and pain scores (a hospital standard measure) will be collected for 48 hours for the study, or until discharge, whichever occurs sooner. The conversion to a morphine equivalent unit allows investigators to compare different narcotics the patient may receive in a more standardized way. The results will be analyzed and compared between the two groups.

Conditions

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Laparoscopic Gastric Bypass Obesity Pain, Postoperative

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

OTHER

Blinding Strategy

SINGLE

Participants

Study Groups

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Non-Ketamine

This group will receive intraoperative narcotics as is usually done for this surgery. This arm will not receive Ketamine.

Group Type ACTIVE_COMPARATOR

Narcotics

Intervention Type DRUG

The narcotic group will receive no ketamine but rather a more standard anesthetic

pain scale

Intervention Type BEHAVIORAL

0-10 pain scale. 0 = no pain and 10 = worst pain

Ketamine

This group will receive an intraoperative infusion of ketamine rather than narcotics to control pain.

Group Type ACTIVE_COMPARATOR

Ketamine

Intervention Type DRUG

Anesthesia of only Ketamine

pain scale

Intervention Type BEHAVIORAL

0-10 pain scale. 0 = no pain and 10 = worst pain

Interventions

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Ketamine

Anesthesia of only Ketamine

Intervention Type DRUG

Narcotics

The narcotic group will receive no ketamine but rather a more standard anesthetic

Intervention Type DRUG

pain scale

0-10 pain scale. 0 = no pain and 10 = worst pain

Intervention Type BEHAVIORAL

Other Intervention Names

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Ketalar

Eligibility Criteria

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Inclusion Criteria

* Obese patient presenting for laparoscopic gastric bypass between 18 and 65 years of age

Exclusion Criteria

* Hypersensitivity, allergy, or contraindications to fentanyl, propofol, or ketamine.
Minimum Eligible Age

18 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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University of Florida

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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David M Smyth, MSN

Role: PRINCIPAL_INVESTIGATOR

Shands Hospital at the University of Florida

Locations

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University of Florida

Gainesville, Florida, United States

Site Status

Countries

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United States

Provided Documents

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Document Type: Study Protocol

View Document

Document Type: Informed Consent Form

View Document

Other Identifiers

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IRB201500836 -A

Identifier Type: -

Identifier Source: org_study_id

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