Biomechanics of Optic Neuropathy

NCT ID: NCT02982499

Last Updated: 2020-10-23

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

TERMINATED

Total Enrollment

10 participants

Study Classification

OBSERVATIONAL

Study Start Date

2016-09-30

Study Completion Date

2018-03-26

Brief Summary

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The participant is being asked to be a subject in this research study because the participant may have a disorder that can cause optic nerve damage and impairment of his/her visual function which is called optic neuropathies (ON). Optic neuropathy refers to damage to the optic nerve (a "cable" connecting the eyes and the brain to transmit the visual signals) due to any cause.In this study, the investigator is using magnetic resonance imaging (MRI) and ophthalmic measures such as optic coherent tomography(OCT), which are non-invasive imaging tests to measure the changes in eye globe shape ,the flow of blood and brain fluid. It is hoped that this study will provide new knowledge that may allow the investigator to better understand the cause of symptoms associated with optic neuropathy and ways to better monitor what is happening.

Detailed Description

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Conditions

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Optic Neuropathy

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

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control group

Healthy participants will receive a one-time assessment of quantitative Magnetic Resonance Imaging (MRI) and spectrum domain optical coherence tomography (OCT).

magnetic resonance image (MRI)

Intervention Type DEVICE

Radiographic imaging that takes about 30-45 minutes

Optical Coherence Tomography (OCT)

Intervention Type DEVICE

Images taken from the back of the eye (retina)

optic neuropathy group

Participants with optic neuropathy will receive a one-time assessment of quantitative Magnetic Resonance Imaging (MRI) and spectrum domain optical coherence tomography (OCT).

magnetic resonance image (MRI)

Intervention Type DEVICE

Radiographic imaging that takes about 30-45 minutes

Optical Coherence Tomography (OCT)

Intervention Type DEVICE

Images taken from the back of the eye (retina)

Interventions

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magnetic resonance image (MRI)

Radiographic imaging that takes about 30-45 minutes

Intervention Type DEVICE

Optical Coherence Tomography (OCT)

Images taken from the back of the eye (retina)

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* 18 years old and on
* Patients with optic neuropathy(10) and age controlled healthy subjects(10)

Exclusion Criteria

* For patients: Subjects with history of neurological or ocular disease other than optic neuropathy and refractory error.
* For healthy control group: History of systemic disease except hypertension.
* Pregnant women and prisoners will be excluded.
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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University of Miami

OTHER

Sponsor Role lead

Responsible Party

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Byron Lam

Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Byron R Lam, MD

Role: PRINCIPAL_INVESTIGATOR

University of Miami

Locations

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Bascom Palmer Eye Institute

Miami, Florida, United States

Site Status

Countries

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United States

Other Identifiers

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20160376

Identifier Type: -

Identifier Source: org_study_id

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