Staying Strong and Healthy During Androgen Deprivation Therapy (ADT) for Men

NCT ID: NCT02969577

Last Updated: 2021-02-17

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

38 participants

Study Classification

INTERVENTIONAL

Study Start Date

2017-03-07

Study Completion Date

2020-07-31

Brief Summary

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The purpose of this study is to learn if lifestyle changes and counseling along with standard medical care, compared to standard medical care alone, can prevent heart problems and diabetes in men who are receiving ADT for prostate cancer treatment.

Detailed Description

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Prostate cancer is a very treatable cancer but those treatments can have long-lasting effects. A kind of hormone therapy called Androgen Deprivation Therapy (ADT) is often used along with other treatments like radiation and has been shown to improve survival. However, ADT can have negative effects especially on the heart and metabolism (the body's system for using and storing energy).

Participation in this study will last for up to 12 months. The study is looking at two different approaches to treating men who are undergoing ADT:

1. Staying Strong \& Healthy Intervention + Usual Care
2. Usual Care

All participants will have blood drawn and be asked questions about how they are feeling during their participation. The men in the Staying Strong \& Healthy Intervention group will also take part in a diet and exercise program and receive counseling from a member of the study team.

Conditions

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Prostate Cancer

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

SUPPORTIVE_CARE

Blinding Strategy

NONE

Study Groups

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Staying Strong & Healthy Intervention (SS&H)

Participants will take part in a 6-month exercise program and diet and nutrition coaching program. Also part of this arm is a nutritional and lifestyle counseling program to be lead by a member of the study team. Participants will also receive the usual care they would normally receive if not taking part in this study.

Group Type EXPERIMENTAL

Exercise Program

Intervention Type BEHAVIORAL

Participants will have a personal training session at the first visit. A member of the study team will discuss strength training and cardiovascular workouts for them to complete over the first 6 months of the study. A member of the study team will then talk with the participant every week for the first 3 months and monthly afterwards until month 6. Participants will be sent exercise videos and be given recommendations for the exercise program via phone calls and will be tailored to the individual. Videos and recommendations will be sent directly to the participant's smartphone.

Diet and Nutrition Coaching

Intervention Type BEHAVIORAL

Diet and nutrition coaching session with an overview of resources on the smartphone. Over the first 6 months, participants will receive healthy recipes and nutritional information on the smartphone.

Usual Care with Attention

Intervention Type OTHER

Participants will receive the usual care for men undergoing ADT. This includes monitoring blood work and answering questions about how they are feeling. Participants will be directed to the IMPACT website for education materials on prostate cancer.

Usual Care with Attention (UCA)

Participants will receive the usual care they would normally receive if not taking part in this study.

Group Type ACTIVE_COMPARATOR

Usual Care with Attention

Intervention Type OTHER

Participants will receive the usual care for men undergoing ADT. This includes monitoring blood work and answering questions about how they are feeling. Participants will be directed to the IMPACT website for education materials on prostate cancer.

Interventions

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Exercise Program

Participants will have a personal training session at the first visit. A member of the study team will discuss strength training and cardiovascular workouts for them to complete over the first 6 months of the study. A member of the study team will then talk with the participant every week for the first 3 months and monthly afterwards until month 6. Participants will be sent exercise videos and be given recommendations for the exercise program via phone calls and will be tailored to the individual. Videos and recommendations will be sent directly to the participant's smartphone.

Intervention Type BEHAVIORAL

Diet and Nutrition Coaching

Diet and nutrition coaching session with an overview of resources on the smartphone. Over the first 6 months, participants will receive healthy recipes and nutritional information on the smartphone.

Intervention Type BEHAVIORAL

Usual Care with Attention

Participants will receive the usual care for men undergoing ADT. This includes monitoring blood work and answering questions about how they are feeling. Participants will be directed to the IMPACT website for education materials on prostate cancer.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Diagnosed with prostate cancer
* Starting or have started ADT (oral or injection) for prostate cancer treatment within the last 3 months
* Re-initiating ADT after being on holiday for longer than their ADT dosage (e.g. If the man's dosage is every six months and he has been off ADT for more than six he is eligible);
* Able to speak and read in English or Spanish
* Reachable consistently by telephone
* Able to travel to KUMC

Exclusion Criteria

* Not diagnosed with prostate cancer
* Not receiving or planning to receive ADT for prostate cancer treatment within the last three months
* Initiating ADT for prostate cancer prior to the previous 3 months or are not on ADT holiday
* Not able to speak and read in English or Spanish
* Not reachable consistently by telephone
* Not able to travel to the study site for data collection
Minimum Eligible Age

21 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

No

Sponsors

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National Institute of Nursing Research (NINR)

NIH

Sponsor Role collaborator

University of Kansas Medical Center

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Sally Maliski, PhD, RN, FAAN

Role: PRINCIPAL_INVESTIGATOR

University of Kansas Medical Center

Locations

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University of California, Los Angeles

Los Angeles, California, United States

Site Status

University of Kansas Medical Center

Kansas City, Kansas, United States

Site Status

Countries

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United States

Other Identifiers

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R01NR014518

Identifier Type: NIH

Identifier Source: secondary_id

View Link

STUDY00004205

Identifier Type: -

Identifier Source: org_study_id

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