Genetic Predisposition for Chronic Non-specific Low Back Pain

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Total Enrollment

100 participants

Study Classification

OBSERVATIONAL

Study Start Date

2016-09-30

Study Completion Date

2018-08-31

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

Patients with inflammatory back pain were shown to differ from healthy controls in genotype of the Angiotensin-converting enzyme (ACE), which regulates vasoconstriction/-dilatation. The aim of this study is to investigate whether genetic reduction of muscle perfusion might be a pathophysiological pathway of how genes influence chronic non-specific low back pain (LBP).

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Predictors of Chronic Non-specific Low Back Pain

NCT02932163

Low Back Pain

COMPLETED

Trunk Muscle Strength, Strength Endurance and Activity in Persons With Low Back Pain

NCT03494452

Low Back Pain

COMPLETED

Non-Specific Chronic Back Pain; Insight From Spatial Aspects of Lumbar Spinal Muscle Activation

NCT01214213

Low Back Pain

COMPLETED

Back Pain - Linking Phenotype to Pain Mechanism and Outcome.

NCT04433299

Low Back Pain

RECRUITING

Prognostic Factors of Disabling Low Back Pain in Patients With Chronic Low Back Pain

NCT02226692

Chronic Low Back Pain Mechanical Low Back Pain

COMPLETED

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

The following genes will be investigated:

* Insertions-/deletions-polymorphism of the angiotensin-converting enzyme (ACE-I/D gene polymorphism; 3 genotypes: ACE-II, ACE-ID, ACE-DD).
* Anti-adhesive extracellular matrix protein Tenascin-C: gene polymorphism rs2104772

The goals of this study are to investigate whether these genotypes correlate with 1) endurance of back muscles, 2) comorbidities such as asthma and diabetes and 3) the risk for LBP as assessed by a LBP-classification tool.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Low Back Pain

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Observational Model Type

CASE_CONTROL

Study Time Perspective

CROSS_SECTIONAL

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Low back pain patients

Low back pain since more than 3 months Age: 18-65 Caucasian race

no intervention

Intervention Type OTHER

observational case-control study

Controls without low back pain

no low back ain Age: 18-65 Caucasian race

no intervention

Intervention Type OTHER

observational case-control study

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

no intervention

observational case-control study

Intervention Type OTHER

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* 18-65

Exclusion Criteria

* Spinal surgery
* Spinal fracture
* Inflammation
* Tumour
* Severe chronic disease which make intensive physical activity impossible (osteoporosis, cardiovascular heart diseases)

Minimum Eligible Age

18 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes