Back Pain - Linking Phenotype to Pain Mechanism and Outcome.

NCT ID: NCT04433299

Last Updated: 2025-02-06

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

150 participants

Study Classification

OBSERVATIONAL

Study Start Date

2019-11-01

Study Completion Date

2025-07-31

Brief Summary

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To investigate whether different clinical, psychophysical and neurophysiological phenotypes can be identified among low back pain patients

Detailed Description

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Low back pain patients will fill in a detailed questionnaire (incl. pain drawing) about their pain. Some of them will undergo a standardized quantitative sensory testing protocol and an fMRI procedure.

Conditions

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Low Back Pain

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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low back pain patients

no intervention

no intervention, observational

Intervention Type OTHER

no intervention, observational

controls

no intervention

no intervention, observational

Intervention Type OTHER

no intervention, observational

Interventions

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no intervention, observational

no intervention, observational

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

-primary complaint: low back pain clinically not attributable to red flags

Exclusion Criteria

* any major medical or psychiatric condition that affects pain sensitivity
* contraindications to MRI
Minimum Eligible Age

18 Years

Maximum Eligible Age

80 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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University of Zurich

OTHER

Sponsor Role collaborator

Balgrist University Hospital

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Petra Schweinhardt, MD, PhD

Role: PRINCIPAL_INVESTIGATOR

Balgrist University Hospital

Locations

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Balgrist University Hospital

Zurich, Canton of Zurich, Switzerland

Site Status RECRUITING

Countries

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Switzerland

Central Contacts

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Lucas Tauschek, BSc

Role: CONTACT

+41 44 386 57 11

Brigitte Wirth, PhD

Role: CONTACT

+41 44 386 57 03

Facility Contacts

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Lucas Tauschek

Role: primary

+41 44 386 57 11

References

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Sirucek L, De Schoenmacker I, Gorrell LM, Lutolf R, Langenfeld A, Baechler M, Wirth B, Hubli M, Zolch N, Schweinhardt P. The periaqueductal gray in chronic low back pain: dysregulated neurotransmitters and function. Pain. 2025 May 15;166(7):1690-1705. doi: 10.1097/j.pain.0000000000003617.

Reference Type DERIVED
PMID: 40372313 (View on PubMed)

Other Identifiers

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2019-00136

Identifier Type: -

Identifier Source: org_study_id

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