Edoxaban Treatment in Routine Clinical Practice in Patients With Venous Thromboembolism in Korea and Taiwan (ETNA-VTE-KOR-TWN)

NCT ID: NCT02952599

Last Updated: 2019-12-23

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Total Enrollment

352 participants

Study Classification

OBSERVATIONAL

Study Start Date

2017-03-27

Study Completion Date

2019-10-29

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

According to current guidelines, duration of anticoagulant treatment after a venous thromboembolic event varies from 3 months to indefinite treatment depending on the estimated risks of venous thromboembolism (VTE) recurrence and bleeding. Current data for edoxaban are limited to a maximum treatment duration of 12 months.

Therefore, this study aims to gather further insight into efficacy (i.e. symptomatic recurrent VTE) and safety (i.e. bleeding events, liver adverse events, all-cause mortality and other drug related adverse events) of extended treatment with edoxaban up to 12 months in an unselected patient population in routine clinical practice.

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Edoxaban is an orally administered anticoagulant that inhibits coagulation factor Xa. It has been approved by the Ministry of Food and Drug Safety (MFDS) in Korea (date: 25th, August 2015) for the: Reduction in the risk of stroke and systemic embolism in patients with non valvular atrial fibrillation (NVAF) Treatment of deep vein thrombosis (DVT) and pulmonary embolism (PE) Reduction in the risk of recurrent DVT and PE, and by Taiwan Food and Drug Administration (TFDA) in Taiwan (date: 24th, February, 2016) for the Prevention of stroke and systemic embolism in adult patients with NVAF with one or more risk factors, such as congestive heart failure, hypertension, age ≥ 75 years, diabetes mellitus, prior stroke or transient ischemic attack (TIA). Treatment of deep vein thrombosis (DVT) and pulmonary embolism (PE) following 5 to 10 days of initial therapy with a parenteral anticoagulant.

According to current guidelines, duration of anticoagulant treatment after a venous thromboembolic event varies from 3 months to indefinite treatment depending on the estimated risks of venous thromboembolism (VTE) recurrence and bleeding. Current data for edoxaban are limited to a maximum treatment duration of 12 months.

This non-interventional study aims to gather further insight into efficacy (i.e. symptomatic recurrent VTE) and safety (i.e. bleeding events, liver adverse events, all-cause mortality and other drug related adverse events) of extended treatment with edoxaban up to 12 months in approximately 350 patients in an unselected patient population in routine clinical practice.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Venous Thromboembolism

Keywords

Explore important study keywords that can help with search, categorization, and topic discovery.

Non-interventional Study Real World Evidence Patients with Acute VTE treated with Edoxaban Efficacy/Safety

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Patients treated with Edoxaban

Patients with established acute initial or recurrent VTE treated with edoxaban according to Summary of Product Characteristics (SmPC). Physician's prescribing behaviour will not be influenced, patients may only be included after the treating physician has made the clinical decision to prescribe edoxaban.

Edoxaban

Intervention Type DRUG

Prescribed according to approved label

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Edoxaban

Prescribed according to approved label

Intervention Type DRUG

Other Intervention Names

Discover alternative or legacy names that may be used to describe the listed interventions across different sources.

Lixiana

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Established acute initial or recurrent VTE
* Patients prescribed treatment with edoxaban according to package information before participation in the trial
* Written informed consent for participation in the study (ICF)
* Not simultaneously participating in any interventional study

Exclusion Criteria

* None
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

Meet the organizations funding or collaborating on the study and learn about their roles.

Daiichi Sankyo

INDUSTRY

Sponsor Role lead

Responsible Party

Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.

Responsibility Role SPONSOR

Principal Investigators

Learn about the lead researchers overseeing the trial and their institutional affiliations.

Global Clinical Leader

Role: STUDY_DIRECTOR

Daiichi Sankyo

Locations

Explore where the study is taking place and check the recruitment status at each participating site.

SoonChunHyang University Hospital Gumi

Gyeongsang, Gumi, South Korea

Site Status

Inje University Haeundae Paik Hospital

Busan, Haeundae-gu, South Korea

Site Status

Seoul National University Hospital

Seoul, Jongno-gu, South Korea

Site Status

Dong-A University Hospital

Seogu, Kwang-Jo Cho, South Korea

Site Status

Pusan National University Hospital

Busan, Seo-gu, South Korea

Site Status

Severance Hospital, Yonsei University Health System

Seoul, Seodaemun-gu, South Korea

Site Status

SoonChunHyang University Hospital Seoul

Seoul, Yongsan-gu, South Korea

Site Status

Keimyung University Dongsan Medical Center

Daegu, , South Korea

Site Status

Yonsei University, Wonju Severance Christian Hospital

Wŏnju, , South Korea

Site Status

Far Eastern Memorial Hospital

New Taipei City, Banciao District, Taiwan

Site Status

Taipei Veterans General Hospital

Taipei, Beitou District, Taiwan

Site Status

Chang Gung Memorial Hospital, KaoHsiung

Kaohsiung City, Niaosong District, Taiwan

Site Status

Cheng Hsin General Hospital

Taipei, Pai-Tou, Taiwan

Site Status

Shin Kong Wu Ho-Su Memorial Hospital

Taipei, Shih Lin District, Taiwan

Site Status

National Taiwan University Hospital

Taipei, Zhongzheng District, Taiwan

Site Status

KaoHsiung Veterans General Hospital

Kaohsiung City, Zuoying District, Taiwan

Site Status

Changhua Christian Hospital

Chang-hua, , Taiwan

Site Status

China Medical University Hospital

Taichung, , Taiwan

Site Status

Taichung Veterans General Hospital

Taichung, , Taiwan

Site Status

Countries

Review the countries where the study has at least one active or historical site.

South Korea Taiwan

References

Explore related publications, articles, or registry entries linked to this study.

Hokusai-VTE Investigators; Buller HR, Decousus H, Grosso MA, Mercuri M, Middeldorp S, Prins MH, Raskob GE, Schellong SM, Schwocho L, Segers A, Shi M, Verhamme P, Wells P. Edoxaban versus warfarin for the treatment of symptomatic venous thromboembolism. N Engl J Med. 2013 Oct 10;369(15):1406-15. doi: 10.1056/NEJMoa1306638. Epub 2013 Aug 31.

Reference Type BACKGROUND
PMID: 23991658 (View on PubMed)

Other Identifiers

Review additional registry numbers or institutional identifiers associated with this trial.

DU176b-D-A4010

Identifier Type: -

Identifier Source: org_study_id