Global Study to Assess the Safety and Effectiveness of Edoxaban (DU-176b) vs Standard Practice of Dosing With Warfarin in Patients With Atrial Fibrillation
NCT ID: NCT00781391
Last Updated: 2019-03-05
Study Results
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View full resultsBasic Information
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COMPLETED
PHASE3
21105 participants
INTERVENTIONAL
2008-11-30
2013-05-31
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
PREVENTION
QUADRUPLE
Study Groups
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Warfarin/placebo edoxaban
Warfarin tablets plus placebo Edoxaban tablets
warfarin tablets
Warfarin tablets plus Edoxaban placebo tablets each taken once daily for 24 months
placebo edoxaban
placebo edoxaban
high dose edoxaban/placebo warfarin
Edoxaban tablets (60mg) plus warfarin placebo tablets
Edoxaban tablets (high dose regimen-60mg)
Edoxaban tablets plus warfarin placebo tablets each taken once daily for 24 months
placebo warfarin
placebo warfarin
low dose edoxaban/placebo warfarin
Edoxaban tablets (30mg) plus warfarin placebo tablets
Edoxaban tablets (low dose regimen-30mg)
Edoxaban tablets plus warfarin placebo tablets each taken once daily for 24 months
placebo warfarin
placebo warfarin
Interventions
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warfarin tablets
Warfarin tablets plus Edoxaban placebo tablets each taken once daily for 24 months
Edoxaban tablets (high dose regimen-60mg)
Edoxaban tablets plus warfarin placebo tablets each taken once daily for 24 months
Edoxaban tablets (low dose regimen-30mg)
Edoxaban tablets plus warfarin placebo tablets each taken once daily for 24 months
placebo warfarin
placebo warfarin
placebo edoxaban
placebo edoxaban
Eligibility Criteria
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Inclusion Criteria
* Able to provide written informed consent.
* History of documented AF within the prior 12 months
* A moderate to high risk of stroke, as defined by CHADS2 index score of at least 2
Exclusion Criteria
* Subjects with moderate or severe mitral stenosis, unresected atrial myxoma, or a mechanical heart valve
* Subjects with any contraindication for anticoagulant agents;
* Subjects with conditions associated with high risk of bleeding or have known or suspected hereditary or acquired bleeding disorders
* Females of childbearing potential including the following:
* Females with a history of tubal-ligation
* Females less than 2 years post-menopausal
21 Years
ALL
No
Sponsors
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The TIMI Study Group
OTHER
Daiichi Sankyo
INDUSTRY
Responsible Party
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Locations
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Birmingham, Alabama, United States
Mobile, Alabama, United States
Gilbert, Arizona, United States
Glendale, Arizona, United States
Lake Havasu City, Arizona, United States
Sierra Vista, Arizona, United States
Tempe, Arizona, United States
Tucson, Arizona, United States
Harrisburg, Arkansas, United States
Hot Springs, Arkansas, United States
Little Rock, Arkansas, United States
Alhambra, California, United States
Anaheim, California, United States
Burbank, California, United States
Chula Vista, California, United States
Encinitas, California, United States
Fountain Valley, California, United States
Glendale, California, United States
Healdsburg, California, United States
Lakewood, California, United States
Long Beach, California, United States
Los Alamitos, California, United States
Los Angeles, California, United States
Los Banos, California, United States
Mather, California, United States
Merced, California, United States
Newport Beach, California, United States
Oceanside, California, United States
Pacific Palisades, California, United States
Palm Springs, California, United States
Pismo Beach, California, United States
Redondo Beach, California, United States
Sacramento, California, United States
San Diego, California, United States
Santa Rosa, California, United States
Torrance, California, United States
Ventura, California, United States
Aurora, Colorado, United States
Colorado Springs, Colorado, United States
Denver, Colorado, United States
Englewood, Colorado, United States
Greeley, Colorado, United States
Bridgeport, Connecticut, United States
Guilford, Connecticut, United States
Hamden, Connecticut, United States
Manchester, Connecticut, United States
New Haven, Connecticut, United States
North Haven, Connecticut, United States
Shelton, Connecticut, United States
Stamford, Connecticut, United States
Trumbull, Connecticut, United States
Newark, Delaware, United States
Washington D.C., District of Columbia, United States
Aventura, Florida, United States
Chipley, Florida, United States
Clearwater, Florida, United States
Daytona Beach, Florida, United States
Daytona Beach, Florida, United States
DeBary, Florida, United States
Deerfield Beach, Florida, United States
Delray Beach, Florida, United States
Delray Beach, Florida, United States
Hialeah, Florida, United States
Hollywood, Florida, United States
Jacksonville, Florida, United States
Jacksonville Beach, Florida, United States
Jupiter, Florida, United States
Leesburg, Florida, United States
Melbourne, Florida, United States
Miami, Florida, United States
Miami, Florida, United States
Naples, Florida, United States
Orange Park, Florida, United States
Orlando, Florida, United States
Ormond Beach, Florida, United States
Panama City, Florida, United States
Pembroke Pines, Florida, United States
Pensacola, Florida, United States
Plantation, Florida, United States
Port Charlotte, Florida, United States
Rockledge, Florida, United States
Saint Augustine, Florida, United States
Sarasota, Florida, United States
St. Petersburg, Florida, United States
Stuart, Florida, United States
Tamarac, Florida, United States
Tampa, Florida, United States
The Villages, Florida, United States
Vero Beach, Florida, United States
West Palm Beach, Florida, United States
Athens, Georgia, United States
Atlanta, Georgia, United States
Conyers, Georgia, United States
Covington, Georgia, United States
Cumming, Georgia, United States
Savannah, Georgia, United States
Snellville, Georgia, United States
Tucker, Georgia, United States
Watkinsville, Georgia, United States
Waycross, Georgia, United States
Woodstock, Georgia, United States
Honolulu, Hawaii, United States
Boise, Idaho, United States
Hayden Lake, Idaho, United States
Bannockburn, Illinois, United States
Belleville, Illinois, United States
Chicago, Illinois, United States
Elgin, Illinois, United States
Joliet, Illinois, United States
Libertyville, Illinois, United States
Maywood, Illinois, United States
Melrose Park, Illinois, United States
Oak Lawn, Illinois, United States
Springfield, Illinois, United States
Winfield, Illinois, United States
Bloomington, Indiana, United States
Munster, Indiana, United States
Ames, Iowa, United States
Council Bluffs, Iowa, United States
Iowa City, Iowa, United States
Shell Rock, Iowa, United States
Wichita, Kansas, United States
Bowling Green, Kentucky, United States
Campbellsville, Kentucky, United States
Elizabethtown, Kentucky, United States
Richmond, Kentucky, United States
Marrero, Louisiana, United States
West Monroe, Louisiana, United States
West Monroe, Louisiana, United States
Auburn, Maine, United States
Biddeford, Maine, United States
Baltimore, Maryland, United States
Bel Air, Maryland, United States
Bethesda, Maryland, United States
Lexington Park, Maryland, United States
Rockville, Maryland, United States
Salisbury, Maryland, United States
Towson, Maryland, United States
Westminster, Maryland, United States
Ayer, Massachusetts, United States
Boston, Massachusetts, United States
Concord, Massachusetts, United States
East Bridgewater, Massachusetts, United States
Haverhill, Massachusetts, United States
Methuen, Massachusetts, United States
Worcester, Massachusetts, United States
Bay City, Michigan, United States
Benzonia, Michigan, United States
Chelsea, Michigan, United States
Commerce, Michigan, United States
Detroit, Michigan, United States
Grand Rapids, Michigan, United States
Interlochen, Michigan, United States
Kalamazoo, Michigan, United States
Lapeer, Michigan, United States
Midland, Michigan, United States
Rochester Hills, Michigan, United States
Saginaw, Michigan, United States
Troy, Michigan, United States
Warren, Michigan, United States
Golden Valley, Minnesota, United States
Minneapolis, Minnesota, United States
Saint Paul, Minnesota, United States
Biloxi, Mississippi, United States
Chesterfield, Missouri, United States
Joplin, Missouri, United States
Kansas City, Missouri, United States
Saint Charles, Missouri, United States
St Louis, Missouri, United States
Kalispell, Montana, United States
Fremont, Nebraska, United States
Grand Island, Nebraska, United States
Lincoln, Nebraska, United States
Omaha, Nebraska, United States
Henderson, Nevada, United States
Belvidere, New Jersey, United States
Brick, New Jersey, United States
Bridgewater, New Jersey, United States
Browns Mills, New Jersey, United States
Cherry Hill, New Jersey, United States
Elizabeth, New Jersey, United States
Haddon Heights, New Jersey, United States
Hamilton, New Jersey, United States
Mine Hill, New Jersey, United States
Ocean City, New Jersey, United States
Passaic, New Jersey, United States
Ridgewood, New Jersey, United States
Somerset, New Jersey, United States
Toms River, New Jersey, United States
Albuquerque, New Mexico, United States
Albany, New York, United States
Brooklyn, New York, United States
Buffalo, New York, United States
Cortlandt Manor, New York, United States
Hawthorne, New York, United States
Jamaica, New York, United States
Mineola, New York, United States
New York, New York, United States
North Massapequa, New York, United States
Saratoga Springs, New York, United States
Troy, New York, United States
Cary, North Carolina, United States
Chapel Hill, North Carolina, United States
Charlotte, North Carolina, United States
Greensboro, North Carolina, United States
Mooresville, North Carolina, United States
Morehead City, North Carolina, United States
Morganton, North Carolina, United States
Morganton, North Carolina, United States
Oxford, North Carolina, United States
Pinehurst, North Carolina, United States
Statesville, North Carolina, United States
Winston-Salem, North Carolina, United States
Fargo, North Dakota, United States
Oakes, North Dakota, United States
Akron, Ohio, United States
Canal Fulton, Ohio, United States
Canton, Ohio, United States
Cincinnati, Ohio, United States
Cleveland, Ohio, United States
Columbus, Ohio, United States
Cuyahoga Falls, Ohio, United States
Dayton, Ohio, United States
Fairfield, Ohio, United States
Marion, Ohio, United States
Middletown, Ohio, United States
Pitsburg, Ohio, United States
Springfield, Ohio, United States
Thornville, Ohio, United States
Toledo, Ohio, United States
Willoughby Hills, Ohio, United States
Bartlesville, Oklahoma, United States
Oklahoma City, Oklahoma, United States
Bend, Oregon, United States
Corvallis, Oregon, United States
Altoona, Pennsylvania, United States
Beaver, Pennsylvania, United States
Chester, Pennsylvania, United States
Clymer, Pennsylvania, United States
Danville, Pennsylvania, United States
Doylestown, Pennsylvania, United States
Ephrata, Pennsylvania, United States
Feasterville, Pennsylvania, United States
Fleetwood, Pennsylvania, United States
Greenville, Pennsylvania, United States
Johnstown, Pennsylvania, United States
Lancaster, Pennsylvania, United States
Lewistown, Pennsylvania, United States
Newport, Pennsylvania, United States
Norristown, Pennsylvania, United States
Philadelphia, Pennsylvania, United States
Pittsburgh, Pennsylvania, United States
Pottstown, Pennsylvania, United States
Scranton, Pennsylvania, United States
Sellersville, Pennsylvania, United States
Somerset, Pennsylvania, United States
State College, Pennsylvania, United States
Uniontown, Pennsylvania, United States
Wilkes-Barre, Pennsylvania, United States
Wynnewood, Pennsylvania, United States
Yardley, Pennsylvania, United States
Providence, Rhode Island, United States
Anderson, South Carolina, United States
Charleston, South Carolina, United States
Columbia, South Carolina, United States
Florence, South Carolina, United States
Greenville, South Carolina, United States
Greer, South Carolina, United States
Mt. Pleasant, South Carolina, United States
Spartanburg, South Carolina, United States
Summerville, South Carolina, United States
Taylors, South Carolina, United States
Walterboro, South Carolina, United States
Rapid City, South Dakota, United States
Columbia, Tennessee, United States
Jackson, Tennessee, United States
Johnson City, Tennessee, United States
Nashville, Tennessee, United States
Oak Ridge, Tennessee, United States
Arlington, Texas, United States
Austin, Texas, United States
Carrollton, Texas, United States
Corsicana, Texas, United States
Dallas, Texas, United States
Fort Worth, Texas, United States
Georgetown, Texas, United States
Grapevine, Texas, United States
Houston, Texas, United States
Lubbock, Texas, United States
McAllen, Texas, United States
Odessa, Texas, United States
Plano, Texas, United States
San Antonio, Texas, United States
Tomball, Texas, United States
Wichita Falls, Texas, United States
Provo, Utah, United States
West Valley City, Utah, United States
Danville, Virginia, United States
Hopewell, Virginia, United States
Newport News, Virginia, United States
Norfolk, Virginia, United States
Richmond, Virginia, United States
Springfield, Virginia, United States
Suffolk, Virginia, United States
Virginia Beach, Virginia, United States
Winchester, Virginia, United States
Bellevue, Washington, United States
Kirkland, Washington, United States
Renton, Washington, United States
Seattle, Washington, United States
Spokane, Washington, United States
Tacoma, Washington, United States
Clarksburg, West Virginia, United States
Madison, Wisconsin, United States
Manitowoc, Wisconsin, United States
Menomonee Falls, Wisconsin, United States
Bahía Blanca, , Argentina
Buenos Aires, , Argentina
Corrientes, , Argentina
Córdoba, , Argentina
Formosa, , Argentina
Godoy Cruz, , Argentina
Mar del Plata, , Argentina
Mendoza, , Argentina
Paraguay, , Argentina
Provincia de Chaco, , Argentina
Provincia de Rio Negro, , Argentina
Provincia de Salta, , Argentina
San Luis, , Argentina
San Miguel de Tucumán, , Argentina
San Salvador de Jujuy, , Argentina
Santa Fe, , Argentina
Sante Fe, , Argentina
Broken Hill, New South Wales, Australia
East Gosford, New South Wales, Australia
Carina Heights, Queensland, Australia
Milton, Queensland, Australia
Adelaide, South Australia, Australia
Frankston, Victoria, Australia
Ashford, , Australia
Camperdown, , Australia
Elizabeth Vale, , Australia
Joondalup, , Australia
Melbourne, , Australia
Parkville, , Australia
Perth, , Australia
Antwerp, , Belgium
Arlon, , Belgium
Bruges, , Belgium
Brussels, , Belgium
Genk, , Belgium
Hasselt, , Belgium
Leuven, , Belgium
Liège, , Belgium
Mechelen, , Belgium
Merksem, , Belgium
Moerkerke, , Belgium
Montegnée, , Belgium
Mousron, , Belgium
Torhout, , Belgium
Veurne, , Belgium
Wetteren, , Belgium
Belo Horizonte, , Brazil
Blumenau, , Brazil
Brasília, , Brazil
Campina Grande do Sul, , Brazil
Campinas, , Brazil
Caxias do Sul, , Brazil
Curitiba, , Brazil
Goiânia, , Brazil
Lajeados, , Brazil
Maceió, , Brazil
Marília, , Brazil
Passo Fundo, , Brazil
Porto Alegre, , Brazil
Recife, , Brazil
Ribeirão Preto, , Brazil
Rio de Janeiro, , Brazil
Salvador, , Brazil
Santo André, , Brazil
São José, , Brazil
São Paulo, , Brazil
Uberlândia, , Brazil
Burgas, , Bulgaria
Dimitrovgrad, , Bulgaria
Haskovo, , Bulgaria
Pleven, , Bulgaria
Plovdiv, , Bulgaria
Rousse, , Bulgaria
Sofia, , Bulgaria
Varna, , Bulgaria
Calgary, Alberta, Canada
Campbell River, British Columbia, Canada
Chilliwack, British Columbia, Canada
Coquitlam, British Columbia, Canada
Kamloops, British Columbia, Canada
Kelowna, British Columbia, Canada
New Westminster, British Columbia, Canada
Penticton, British Columbia, Canada
Quesnel, British Columbia, Canada
Victoria, British Columbia, Canada
Saint John, New Brunswick, Canada
Bridgewater, Nova Scotia, Canada
Halifax, Nova Scotia, Canada
Liverpool, Nova Scotia, Canada
Ajax, Ontario, Canada
Beamsville, Ontario, Canada
Brampton, Ontario, Canada
Corunna, Ontario, Canada
Greater Sudbury, Ontario, Canada
Hamilton, Ontario, Canada
Kitchener, Ontario, Canada
Listowel, Ontario, Canada
London, Ontario, Canada
Oshawa, Ontario, Canada
Ottawa, Ontario, Canada
Richmond Hill, Ontario, Canada
Sarnia, Ontario, Canada
Scarborough Village, Ontario, Canada
Toronto, Ontario, Canada
Greenfield Park, Quebec, Canada
Longueuil, Quebec, Canada
Montreal, Quebec, Canada
Québec, Quebec, Canada
Saint Georges de Beauce, Quebec, Canada
Saint-Charles-Borromée, Quebec, Canada
Saint-Jérôme, Quebec, Canada
Saint-Lambert, Quebec, Canada
Terrebonne, Quebec, Canada
Trois-Rivières, Quebec, Canada
Westmount, Quebec, Canada
Saskatoon, Saskatchewan, Canada
Mount Pearl, , Canada
St. John's, , Canada
Iquique, , Chile
La Serena, , Chile
Osorno, , Chile
Port Montt, , Chile
Rancagua, , Chile
Santiago, , Chile
Talcahuano, , Chile
Temuco, , Chile
Victoria, , Chile
Viña del Mar, , Chile
Baotou, , China
Beijing, , China
Changchun, , China
Changsha, , China
Chendu, , China
Chongqing, , China
Guangxi, , China
Guangzhou, , China
Hainan Province, , China
Hangzhou, , China
Harbin, , China
Jinzhou, , China
Lanzhou, , China
Liaoning Province, , China
Nanchang, , China
Shaanxi Province, , China
Shanghai, , China
Shenyang, , China
Shijiazhuang, , China
Tianjin, , China
Wenzhou, , China
Wuhan, , China
Antioquia, , Colombia
Armenia, , Colombia
Barranquilla, , Colombia
Bogotá, , Colombia
Bucaramanga, , Colombia
Cartagena, , Colombia
Envigado, , Colombia
Manizales, , Colombia
Medellín, , Colombia
Dubrovnik, , Croatia
Karlovac, , Croatia
Koprivnica, , Croatia
Krapinski Toplice, , Croatia
Osijek, , Croatia
Rijeka, , Croatia
Slavonski Brod, , Croatia
Split, , Croatia
Varaždin, , Croatia
Zadar, , Croatia
Zagreb, , Croatia
Benátky nad Jizerou, , Czechia
Benešov, , Czechia
Bílovec, , Czechia
Brno, , Czechia
Brno-Lesna, , Czechia
Chrudim, , Czechia
Český Krumlov, , Czechia
Havlickux Brod, , Czechia
Hradec Králové, , Czechia
Hranice, , Czechia
Jindřichův Hradec, , Czechia
Kolín, , Czechia
Kroměříž, , Czechia
Mariánské Lázně, , Czechia
Mladá Boleslav, , Czechia
Náchod, , Czechia
Ostrava, , Czechia
Ostrava-Trebovice, , Czechia
Pardubice, , Czechia
Pilsen, , Czechia
Prague, , Czechia
Příbram, , Czechia
Řevnice, , Czechia
Semily, , Czechia
Slaný, , Czechia
Teplice, , Czechia
Trutnov, , Czechia
Ústí nad Labem, , Czechia
Aarhus N, , Denmark
Copenhagen, , Denmark
Esbjerg, , Denmark
Frederiksberg, , Denmark
Glostrup Municipality, , Denmark
Hellerup, , Denmark
Holbæk, , Denmark
Horsens, , Denmark
Haabneeme, Harju, Estonia
Puusepa, Tartu, Estonia
Pärnu, , Estonia
Tallinn, , Estonia
Tartu, , Estonia
Jyväskylä, , Finland
Kuopio, , Finland
Lappeenranta, , Finland
Oulu, , Finland
Seinäjoki, , Finland
Tampere, , Finland
Abbeville, , France
Amiens, , France
Brest, , France
Cambrai, , France
Clamart, , France
La Roche-sur-Yon, , France
Lille, , France
Lyon, , France
Massy, , France
Nantes, , France
Paris, , France
Pau, , France
Pessac, , France
Poitiers, , France
Tours, , France
Valenciennes, , France
Altenburg, , Germany
Aschaffenburg, , Germany
Augsburg, , Germany
Bad Nauheim, , Germany
Berlin, , Germany
Bochum, , Germany
Cloppenburg, , Germany
Cologne, , Germany
Dortmund, , Germany
Dresden, , Germany
Essen, , Germany
Frankfurt, , Germany
Giengen an der Brenz, , Germany
Görlitz, , Germany
Großheirath, , Germany
Hamburg, , Germany
Heidelberg, , Germany
Heilbronn, , Germany
Homburg, , Germany
Ingelheim, , Germany
Kallstadt, , Germany
Kassel, , Germany
Kiel-Kronshagen, , Germany
Leipzig, , Germany
Ludwigshafen, , Germany
Lübeck, , Germany
Magdeburg, , Germany
Mainz, , Germany
Mannheim, , Germany
Markkleeberg, , Germany
München, , Germany
Nienburg, , Germany
Northeinm, , Germany
Offenbach-beiber, , Germany
Potsdam, , Germany
Rüdersdorf, , Germany
Siegen, , Germany
Stuhr, , Germany
Ulm, , Germany
Unterschneidheim, , Germany
Wardenburg, , Germany
Wermsdorf, , Germany
Weyhe, , Germany
Witten, , Germany
Woerishofen, , Germany
Wuppertal, , Germany
Athens, , Greece
Larissa, , Greece
Rhodes, , Greece
Rio-Patras, , Greece
Thessaloniki, , Greece
Trikala, , Greece
Voula, , Greece
Ciudad, , Guatemala
Clinica, , Guatemala
Edificio Multimedica, , Guatemala
Nivel, , Guatemala
Oficina, , Guatemala
Quetzaltenango, , Guatemala
Zacapa, , Guatemala
Ajka, , Hungary
Baja, , Hungary
Békéscsaba, , Hungary
Budapest, , Hungary
Debrecen, , Hungary
Hódmezővásárhely, , Hungary
Kecskemét, , Hungary
Keeskemet, , Hungary
Kistarcsa, , Hungary
Komárom, , Hungary
Makó, , Hungary
Nagykanizsa, , Hungary
Nyíregyháza, , Hungary
Pécs, , Hungary
Sopron, , Hungary
Szekszárd, , Hungary
Szombathely, , Hungary
Zalaegerszeg, , Hungary
Hyderabad, Andhra Pradesh, India
Vijayawada, Andhra Pradesh, India
Angamaly, Kerala, India
Kochi, Kerala, India
Thrissur, Kerala, India
Ahmedabad, , India
Anddhra Pradesh, , India
Andhra Pradesh, , India
Aurangabad, , India
Bangalore, , India
Bikaner, , India
Chennai, , India
Coimbatore, , India
Delhi, , India
Gujrāt, , India
Indore, , India
Jaipur, , India
Karnataka, , India
Kerala, , India
Kolkata, , India
Ludhiana, , India
Madhya Pradesh, , India
Maharashtra, , India
Mangalore, , India
Mumbai, , India
Nagpur, , India
Nashik, , India
New Delhi, , India
Pune, , India
Punjab, , India
Pūni, , India
Rajasthan, , India
Ramnagar, , India
Shimoga, , India
Surat, , India
Trivandrum, , India
Vadodara, , India
Afula, , Israel
Beersheba, , Israel
Dimona, , Israel
Giv‘atayim, , Israel
Hadera, , Israel
Haifa, , Israel
Holon, , Israel
Jerusalem, , Israel
Kfar Saba, , Israel
Nahariya, , Israel
Nazareth, , Israel
Petah Tikva, , Israel
Poria – Neve Oved, , Israel
Raanana, , Israel
Rehovot, , Israel
Tel Aviv, , Israel
Tel Litwinsky, , Israel
Ẕerifin, , Israel
Bologna, , Italy
Brescia, , Italy
Cantania, , Italy
Casarano, , Italy
Caserta, , Italy
Chieti, , Italy
Cremona, , Italy
Genova, , Italy
Grosseto, , Italy
Legnano, , Italy
Manerbio, , Italy
Milan, , Italy
Monserrato, , Italy
Napoli, , Italy
Novara, , Italy
Ostia Antica, , Italy
Pavia, , Italy
Pisa, , Italy
Pozzuoli, , Italy
Roma, , Italy
Santa Maria Capua Vetere, , Italy
Sassari, , Italy
Seriate, , Italy
Siena, , Italy
Trieste, , Italy
Venezia Mestre, , Italy
Kyoto, Kyoto, Japan
Lida-shi, Nagano, Japan
Ueda-shi, Nagano, Japan
Minato-ku, Tokyo, Japan
Aichi, , Japan
Aomori, , Japan
Chiaki, , Japan
Chiba, , Japan
Ehime, , Japan
Fukuoka, , Japan
Fukushima, , Japan
Gifu, , Japan
Gunma, , Japan
Hiroshima, , Japan
Hokkai-do, , Japan
Hokkaido, , Japan
Hyōgo, , Japan
Ibaraki, , Japan
Isesaki-shi, , Japan
Ishikawa, , Japan
Kagawa, , Japan
Kanagawa, , Japan
Kumamoto, , Japan
Kyoda, , Japan
Mie, , Japan
Miyagi, , Japan
Nagaoka-shi, , Japan
Nagasaki, , Japan
Niigata, , Japan
Numakunai, , Japan
Okayama, , Japan
Osaka, , Japan
Saitama, , Japan
Shimane, , Japan
Shizuoka, , Japan
Tokushima, , Japan
Tokyo, , Japan
Yamaguchi, , Japan
Yokohama, , Japan
Guadalajara, Jalisco, Mexico
Xalapa, Veracruz, Mexico
Aguascalientes, , Mexico
Chihuahua City, , Mexico
Distrito Federal, , Mexico
Durango, , Mexico
Monterrey, , Mexico
San Luis Potosí City, , Mexico
Yucatán, , Mexico
Almere Stad, , Netherlands
Amstelveen, , Netherlands
Amsterdam, , Netherlands
Dordrecht, , Netherlands
Eindhoven, , Netherlands
Ewijk, , Netherlands
Leiderdorp, , Netherlands
Maastricht, , Netherlands
Rotterdam, , Netherlands
Venlo, , Netherlands
Wildervlank, , Netherlands
Lower Hutt, Wellington Region, New Zealand
Auckland, , New Zealand
Christchurch, , New Zealand
Dunedin, , New Zealand
Hamilton, , New Zealand
Nelson, , New Zealand
Tauranga, , New Zealand
Bodø, , Norway
Harstad, , Norway
Haugesund, , Norway
Oslo, , Norway
Rud, , Norway
Arequipa, , Peru
Callao, , Peru
Lima, , Peru
Cebu, , Philippines
Cebu City, , Philippines
Davao City, , Philippines
Pasig, , Philippines
Quezon City, , Philippines
Ostrów, Mazowiecka, Poland
Bydgoszcz, , Poland
Chojnice, , Poland
Elblag, , Poland
Ełk, , Poland
Gdansk, , Poland
Inowrocław, , Poland
Jarosław, , Poland
Katowice, , Poland
Komenskiego, , Poland
Kołobrzeg, , Poland
Krakow, , Poland
Kutno, , Poland
Libiąż, , Poland
Lodz, , Poland
Lubartów, , Poland
Lublin, , Poland
Pomorskie, , Poland
Puławy, , Poland
Płock, , Poland
Ruda Śląska, , Poland
Rzeszów, , Poland
Skierniewice, , Poland
Sopot, , Poland
Sucharskiego, , Poland
Szczecin, , Poland
Tarnów, , Poland
Torun, , Poland
Warsaw, , Poland
Warzawa, , Poland
Wroclaw, , Poland
Amadora, , Portugal
Aveiro, , Portugal
Braga, , Portugal
Coimbra, , Portugal
Leiria, , Portugal
Lisbon, , Portugal
Ponta Delgada, , Portugal
Setúbal, , Portugal
Viseu, , Portugal
Bacau, , Romania
Brasov, , Romania
Brăila, , Romania
Buccuresti, , Romania
Bucharest, , Romania
Buzău, , Romania
Covasna, , Romania
Dambovita, , Romania
Iași, , Romania
Judetul Maramures, , Romania
Judetul Mures, , Romania
Judetul Suceava, , Romania
Judetul Vrancea, , Romania
Oradea, , Romania
Timișoara, , Romania
Barnaul, , Russia
Chelyabinsk, , Russia
Kemerovo, , Russia
Krasnoyarsk, , Russia
Moscow, , Russia
Nizhny Novgorod, , Russia
Novosibirsk, , Russia
Omsk, , Russia
Orenburg, , Russia
Perm, , Russia
Ryazan, , Russia
Saint Petersburg, , Russia
Saratov, , Russia
Smolensk, , Russia
Tula, , Russia
Tyumen, , Russia
Volgograd, , Russia
Voronezh, , Russia
Yaroslavl, , Russia
Belgrade, , Serbia
Kamenitz, , Serbia
Niš, , Serbia
Niška Banja, , Serbia
Zemun, , Serbia
Zmaj Jovina, , Serbia
Bardejov, , Slovakia
Bratislava, , Slovakia
Dolný Kubín, , Slovakia
Galanta, , Slovakia
Košice, , Slovakia
Levice, , Slovakia
Lučenec, , Slovakia
Nitra, , Slovakia
Nové Zámky, , Slovakia
Prešov, , Slovakia
Rimavská Sobota, , Slovakia
Alberton, , South Africa
Benoni, , South Africa
Bloemfontein, , South Africa
Cape Town, , South Africa
Diepkloof, , South Africa
Durban, , South Africa
Lyttelton, , South Africa
Parktown West, , South Africa
Port Elizabeth, , South Africa
Potchefstroom, , South Africa
Pretoria, , South Africa
Somerset West, , South Africa
Worcester, , South Africa
Busan, , South Korea
Daegu, , South Korea
Daejeon, , South Korea
Gangwon-do, , South Korea
Gwangju, , South Korea
Gyeonggi-do, , South Korea
Incheon, , South Korea
Pusan, , South Korea
Seoul, , South Korea
A Coruña, , Spain
Alcoy, , Spain
Almería, , Spain
Barcelona, , Spain
Bilbao, , Spain
De La Castellana, , Spain
Donostia / San Sebastian, , Spain
Figueras, , Spain
Jaén, , Spain
Lleida, , Spain
Madrid, , Spain
Murcia, , Spain
Santiago de Compostela, , Spain
Seville, , Spain
Vigo, , Spain
Vitoria-Gasteiz, , Spain
Alingsås, , Sweden
Enköping, , Sweden
Gothenburg, , Sweden
Halmstad, , Sweden
Karlshamn, , Sweden
Köping, , Sweden
Lindesberg, , Sweden
Luleå, , Sweden
Lund, , Sweden
Malmo, , Sweden
Mora, , Sweden
Mölndal, , Sweden
Örebro, , Sweden
Skene, , Sweden
Umeå, , Sweden
Uppsala, , Sweden
Varberg, , Sweden
Lausanne, , Switzerland
Lugano, , Switzerland
Changhua, , Taiwan
Hualien City, , Taiwan
Kaohsiung City, , Taiwan
Taichung, , Taiwan
Taipei, , Taiwan
Taoyuan, , Taiwan
Yongkang District, , Taiwan
Bangkok, , Thailand
Chang Mai, , Thailand
Khon Kaen, , Thailand
Nakhon Ratchasima, , Thailand
Pathum Thani, , Thailand
Sai Mai, , Thailand
Songkhla, , Thailand
Adana, , Turkey (Türkiye)
Ankara, , Turkey (Türkiye)
Antalya, , Turkey (Türkiye)
Aydin, , Turkey (Türkiye)
Erzurum, , Turkey (Türkiye)
Eskişehir, , Turkey (Türkiye)
Isparta, , Turkey (Türkiye)
Istanbul, , Turkey (Türkiye)
Izmir, , Turkey (Türkiye)
Konya, , Turkey (Türkiye)
Sivas, , Turkey (Türkiye)
Cherkasy, , Ukraine
Chernihiv, , Ukraine
Dnipropetrovsk, , Ukraine
Donetsk, , Ukraine
Ivano-Frankivsh, , Ukraine
Ivano-Frankivsk, , Ukraine
Kharkiv, , Ukraine
Kherson, , Ukraine
Kyiv, , Ukraine
Luhansk, , Ukraine
Lutsk, , Ukraine
Lviv, , Ukraine
Mykolayiv, , Ukraine
Odesa, , Ukraine
Poltava, , Ukraine
Uzhhorod, , Ukraine
Vinnytsia, , Ukraine
Zaporizhzhya, , Ukraine
Birmingham, , United Kingdom
Blackpool, , United Kingdom
Bournemouth, , United Kingdom
Bradford, , United Kingdom
Cambridge, , United Kingdom
Chesterfield, , United Kingdom
Coventry, , United Kingdom
Devon, , United Kingdom
Dundee, , United Kingdom
East Horsley, , United Kingdom
East Sussex, , United Kingdom
Edinburgh, , United Kingdom
Essex, , United Kingdom
Glasgow, , United Kingdom
Harrow, , United Kingdom
Leicester, , United Kingdom
Liverpool, , United Kingdom
London, , United Kingdom
Middlesbrough, , United Kingdom
Orpington, , United Kingdom
Peterborough, , United Kingdom
Portadown, , United Kingdom
Sheffield, , United Kingdom
Stirling, , United Kingdom
Stockport, , United Kingdom
Surrey, , United Kingdom
Sutton Coldfield, , United Kingdom
Swindon, , United Kingdom
Warwickshire, , United Kingdom
Wolverhampton, , United Kingdom
York, , United Kingdom
Countries
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References
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Semco RS, Bergmark RW, Murphy SA, Cange AL, Unverdorben M, Chen CZL, Ruff CT, Antman EM, Giugliano RP, Bergmark BA. Epistaxis Versus Nonepistaxis Bleeding in Anticoagulated Patients With Atrial Fibrillation: Results From the ENGAGE AF-TIMI 48 Trial. J Am Heart Assoc. 2025 Jan 21;14(2):e031434. doi: 10.1161/JAHA.123.031434. Epub 2025 Jan 10.
Zimerman A, Braunwald E, Steffel J, Van Mieghem NM, Palazzolo MG, Murphy SA, Chen CZL, Unverdorben M, Ruff CT, Antman EM, Giugliano RP. Dose Reduction of Edoxaban in Patients 80 Years and Older With Atrial Fibrillation: Post Hoc Analysis of the ENGAGE AF-TIMI 48 Randomized Clinical Trial. JAMA Cardiol. 2024 Sep 1;9(9):817-825. doi: 10.1001/jamacardio.2024.1793.
Bergmark BA, Park JG, Hamershock RA, Melloni GEM, De Caterina R, Antman EM, Ruff CT, Rutman H, Mercuri MF, Lanz HJ, Braunwald E, Giugliano RP. Application of the Win Ratio Method in the ENGAGE AF-TIMI 48 Trial Comparing Edoxaban With Warfarin in Patients With Atrial Fibrillation. Circ Cardiovasc Qual Outcomes. 2024 Jul;17(7):e010561. doi: 10.1161/CIRCOUTCOMES.123.010561. Epub 2024 Jun 3.
Inciardi RM, Giugliano RP, Park JG, Nordio F, Ruff CT, Chen C, Lanz HJ, Antman EM, Braunwald E, Solomon SD. Risks of Heart Failure, Stroke, and Bleeding in Atrial Fibrillation According to Heart Failure Phenotypes. JACC Clin Electrophysiol. 2023 Apr;9(4):569-580. doi: 10.1016/j.jacep.2022.11.032. Epub 2023 Feb 22.
Oyama K, Giugliano RP, Ruff CT, Berg DD, Jarolim P, Tang M, Park JG, Lanz HJ, Antman EM, Braunwald E, Morrow DA. Serial assessment of biomarkers and heart failure outcomes in patients with atrial fibrillation. Eur J Heart Fail. 2023 Jun;25(6):832-841. doi: 10.1002/ejhf.2844. Epub 2023 Apr 18.
Bonaca MP, Antman EM, Cunningham JW, Wiviott SD, Murphy SA, Halperin JL, Weitz JI, Grosso MA, Lanz HJ, Braunwald E, Giugliano RP, Ruff CT. Ischaemic and bleeding risk in atrial fibrillation with and without peripheral artery disease and efficacy and safety of full- and half-dose edoxaban vs. warfarin: insights from ENGAGE AF-TIMI 48. Eur Heart J Cardiovasc Pharmacother. 2022 Sep 29;8(7):695-706. doi: 10.1093/ehjcvp/pvab089.
Oyama K, Giugliano RP, Berg DD, Ruff CT, Jarolim P, Tang M, Murphy SA, Lanz HJ, Grosso MA, Antman EM, Braunwald E, Morrow DA. Serial assessment of biomarkers and the risk of stroke or systemic embolism and bleeding in patients with atrial fibrillation in the ENGAGE AF-TIMI 48 trial. Eur Heart J. 2021 May 1;42(17):1698-1706. doi: 10.1093/eurheartj/ehab141.
Steffel J, Ruff CT, Yin O, Braunwald E, Park JG, Murphy SA, Connolly S, Antman EM, Giugliano RP. Randomized, Double-Blind Comparison of Half-Dose Versus Full-Dose Edoxaban in 14,014 Patients With Atrial Fibrillation. J Am Coll Cardiol. 2021 Mar 9;77(9):1197-1207. doi: 10.1016/j.jacc.2020.12.053.
Wilkinson C, Wu J, Searle SD, Todd O, Hall M, Kunadian V, Clegg A, Rockwood K, Gale CP. Clinical outcomes in patients with atrial fibrillation and frailty: insights from the ENGAGE AF-TIMI 48 trial. BMC Med. 2020 Dec 24;18(1):401. doi: 10.1186/s12916-020-01870-w.
Vilain K, Li H, Kwong WJ, Antman EM, Ruff CT, Braunwald E, Cohen DJ, Giugliano RP, Magnuson EA; ENGAGE AF-TIMI 48 Trial Investigators. Cardiovascular- and Bleeding-Related Hospitalization Rates With Edoxaban Versus Warfarin in Patients With Atrial Fibrillation Based on Results of the ENGAGE AF-TIMI 48 Trial. Circ Cardiovasc Qual Outcomes. 2020 Nov;13(11):e006511. doi: 10.1161/CIRCOUTCOMES.120.006511. Epub 2020 Nov 5.
Inciardi RM, Giugliano RP, Claggett B, Gupta DK, Chandra A, Ruff CT, Antman EM, Mercuri MF, Grosso MA, Braunwald E, Solomon SD; ENGAGE AF-TIMI 48 Investigators. Left atrial structure and function and the risk of death or heart failure in atrial fibrillation. Eur J Heart Fail. 2019 Dec;21(12):1571-1579. doi: 10.1002/ejhf.1606. Epub 2019 Nov 27.
Bergmark BA, Kamphuisen PW, Wiviott SD, Ruff CT, Antman EM, Nordio F, Kuder JF, Mercuri MF, Lanz HJ, Braunwald E, Giugliano RP. Comparison of Events Across Bleeding Scales in the ENGAGE AF-TIMI 48 Trial. Circulation. 2019 Nov 26;140(22):1792-1801. doi: 10.1161/CIRCULATIONAHA.119.041346. Epub 2019 Oct 10.
Berg DD, Ruff CT, Jarolim P, Giugliano RP, Nordio F, Lanz HJ, Mercuri MF, Antman EM, Braunwald E, Morrow DA. Performance of the ABC Scores for Assessing the Risk of Stroke or Systemic Embolism and Bleeding in Patients With Atrial Fibrillation in ENGAGE AF-TIMI 48. Circulation. 2019 Feb 5;139(6):760-771. doi: 10.1161/CIRCULATIONAHA.118.038312.
Corbalan R, Nicolau JC, Lopez-Sendon J, Garcia-Castillo A, Botero R, Sotomora G, Horna M, Ruff CT, Hamershock RA, Grip LT, Antman EM, Braunwald E, Giugliano RP. Edoxaban Versus Warfarin in Latin American Patients With Atrial Fibrillation: The ENGAGE AF-TIMI 48 Trial. J Am Coll Cardiol. 2018 Sep 25;72(13):1466-1475. doi: 10.1016/j.jacc.2018.07.037.
Yin OQP, Antman EM, Braunwald E, Mercuri MF, Miller R, Morrow D, Ruff CT, Truitt K, Weitz JI, Giugliano RP. Linking Endogenous Factor Xa Activity, a Biologically Relevant Pharmacodynamic Marker, to Edoxaban Plasma Concentrations and Clinical Outcomes in the ENGAGE AF-TIMI 48 Trial. Circulation. 2018 Oct 30;138(18):1963-1973. doi: 10.1161/CIRCULATIONAHA.118.033933.
Aisenberg J, Chatterjee-Murphy P, Friedman Flack K, Weitz JI, Ruff CT, Nordio F, Mercuri MF, Choi Y, Antman EM, Braunwald E, Giugliano RP. Gastrointestinal Bleeding With Edoxaban Versus Warfarin: Results From the ENGAGE AF-TIMI 48 Trial (Effective Anticoagulation With Factor Xa Next Generation in Atrial Fibrillation-Thrombolysis In Myocardial Infarction). Circ Cardiovasc Qual Outcomes. 2018 May;11(5):e003998. doi: 10.1161/CIRCOUTCOMES.117.003998.
Wang K, Li H, Kwong WJ, Antman EM, Ruff CT, Giugliano RP, Cohen DJ, Magnuson EA; ENGAGE AF-TIMI 48 Trial Investigators. Impact of Spontaneous Extracranial Bleeding Events on Health State Utility in Patients with Atrial Fibrillation: Results from the ENGAGE AF-TIMI 48 Trial. J Am Heart Assoc. 2017 Aug 11;6(8):e006703. doi: 10.1161/JAHA.117.006703.
Eisen A, Ruff CT, Braunwald E, Hamershock RA, Lewis BS, Hassager C, Chao TF, Le Heuzey JY, Mercuri M, Rutman H, Antman EM, Giugliano RP. Digoxin Use and Subsequent Clinical Outcomes in Patients With Atrial Fibrillation With or Without Heart Failure in the ENGAGE AF-TIMI 48 Trial. J Am Heart Assoc. 2017 Jun 30;6(7):e006035. doi: 10.1161/JAHA.117.006035.
De Caterina R, Renda G, Carnicelli AP, Nordio F, Trevisan M, Mercuri MF, Ruff CT, Antman EM, Braunwald E, Giugliano RP. Valvular Heart Disease Patients on Edoxaban or Warfarin in the ENGAGE AF-TIMI 48 Trial. J Am Coll Cardiol. 2017 Mar 21;69(11):1372-1382. doi: 10.1016/j.jacc.2016.12.031.
Link MS, Giugliano RP, Ruff CT, Scirica BM, Huikuri H, Oto A, Crompton AE, Murphy SA, Lanz H, Mercuri MF, Antman EM, Braunwald E; ENGAGE AF-TIMI 48 Investigators. Stroke and Mortality Risk in Patients With Various Patterns of Atrial Fibrillation: Results From the ENGAGE AF-TIMI 48 Trial (Effective Anticoagulation With Factor Xa Next Generation in Atrial Fibrillation-Thrombolysis in Myocardial Infarction 48). Circ Arrhythm Electrophysiol. 2017 Jan;10(1):e004267. doi: 10.1161/CIRCEP.116.004267.
Ruff CT, Giugliano RP, Braunwald E, Murphy SA, Brown K, Jarolim P, Mercuri M, Antman EM, Morrow DA. Cardiovascular Biomarker Score and Clinical Outcomes in Patients With Atrial Fibrillation: A Subanalysis of the ENGAGE AF-TIMI 48 Randomized Clinical Trial. JAMA Cardiol. 2016 Dec 1;1(9):999-1006. doi: 10.1001/jamacardio.2016.3311.
Steffel J, Giugliano RP, Braunwald E, Murphy SA, Mercuri M, Choi Y, Aylward P, White H, Zamorano JL, Antman EM, Ruff CT. Edoxaban Versus Warfarin in Atrial Fibrillation Patients at Risk of Falling: ENGAGE AF-TIMI 48 Analysis. J Am Coll Cardiol. 2016 Sep 13;68(11):1169-1178. doi: 10.1016/j.jacc.2016.06.034.
Eisen A, Ruff CT, Braunwald E, Nordio F, Corbalan R, Dalby A, Dorobantu M, Mercuri M, Lanz H, Rutman H, Wiviott SD, Antman EM, Giugliano RP. Sudden Cardiac Death in Patients With Atrial Fibrillation: Insights From the ENGAGE AF-TIMI 48 Trial. J Am Heart Assoc. 2016 Jul 8;5(7):e003735. doi: 10.1161/JAHA.116.003735.
Rost NS, Giugliano RP, Ruff CT, Murphy SA, Crompton AE, Norden AD, Silverman S, Singhal AB, Nicolau JC, SomaRaju B, Mercuri MF, Antman EM, Braunwald E; ENGAGE AF-TIMI 48 Investigators. Outcomes With Edoxaban Versus Warfarin in Patients With Previous Cerebrovascular Events: Findings From ENGAGE AF-TIMI 48 (Effective Anticoagulation With Factor Xa Next Generation in Atrial Fibrillation-Thrombolysis in Myocardial Infarction 48). Stroke. 2016 Aug;47(8):2075-82. doi: 10.1161/STROKEAHA.116.013540. Epub 2016 Jul 7.
Bohula EA, Giugliano RP, Ruff CT, Kuder JF, Murphy SA, Antman EM, Braunwald E. Impact of Renal Function on Outcomes With Edoxaban in the ENGAGE AF-TIMI 48 Trial. Circulation. 2016 Jul 5;134(1):24-36. doi: 10.1161/CIRCULATIONAHA.116.022361.
Kato ET, Giugliano RP, Ruff CT, Koretsune Y, Yamashita T, Kiss RG, Nordio F, Murphy SA, Kimura T, Jin J, Lanz H, Mercuri M, Braunwald E, Antman EM. Efficacy and Safety of Edoxaban in Elderly Patients With Atrial Fibrillation in the ENGAGE AF-TIMI 48 Trial. J Am Heart Assoc. 2016 May 20;5(5):e003432. doi: 10.1161/JAHA.116.003432.
Xu H, Ruff CT, Giugliano RP, Murphy SA, Nordio F, Patel I, Shi M, Mercuri M, Antman EM, Braunwald E. Concomitant Use of Single Antiplatelet Therapy With Edoxaban or Warfarin in Patients With Atrial Fibrillation: Analysis From the ENGAGE AF-TIMI48 Trial. J Am Heart Assoc. 2016 Feb 23;5(2):e002587. doi: 10.1161/JAHA.115.002587.
Ruff CT, Giugliano RP, Braunwald E, Morrow DA, Murphy SA, Kuder JF, Deenadayalu N, Jarolim P, Betcher J, Shi M, Brown K, Patel I, Mercuri M, Antman EM. Association between edoxaban dose, concentration, anti-Factor Xa activity, and outcomes: an analysis of data from the randomised, double-blind ENGAGE AF-TIMI 48 trial. Lancet. 2015 Jun 6;385(9984):2288-95. doi: 10.1016/S0140-6736(14)61943-7. Epub 2015 Mar 11.
Mega JL, Walker JR, Ruff CT, Vandell AG, Nordio F, Deenadayalu N, Murphy SA, Lee J, Mercuri MF, Giugliano RP, Antman EM, Braunwald E, Sabatine MS. Genetics and the clinical response to warfarin and edoxaban: findings from the randomised, double-blind ENGAGE AF-TIMI 48 trial. Lancet. 2015 Jun 6;385(9984):2280-7. doi: 10.1016/S0140-6736(14)61994-2. Epub 2015 Mar 11.
Ruff CT, Giugliano RP, Braunwald E, Mercuri M, Curt V, Betcher J, Grip L, Cange AL, Crompton AE, Murphy SA, Deenadayalu N, Antman EM. Transition of patients from blinded study drug to open-label anticoagulation: the ENGAGE AF-TIMI 48 trial. J Am Coll Cardiol. 2014 Aug 12;64(6):576-84. doi: 10.1016/j.jacc.2014.05.028.
Giugliano RP, Ruff CT, Rost NS, Silverman S, Wiviott SD, Lowe C, Deenadayalu N, Murphy SA, Grip LT, Betcher JM, Duggal A, Dave J, Shi M, Mercuri M, Antman EM, Braunwald E; ENGAGE AF-TIMI 48 Investigators. Cerebrovascular events in 21 105 patients with atrial fibrillation randomized to edoxaban versus warfarin: Effective Anticoagulation with Factor Xa Next Generation in Atrial Fibrillation-Thrombolysis in Myocardial Infarction 48. Stroke. 2014 Aug;45(8):2372-8. doi: 10.1161/STROKEAHA.114.006025. Epub 2014 Jun 19.
Gupta DK, Shah AM, Giugliano RP, Ruff CT, Antman EM, Grip LT, Deenadayalu N, Hoffman E, Patel I, Shi M, Mercuri M, Mitrovic V, Braunwald E, Solomon SD; Effective aNticoaGulation with factor xA next GEneration in AF-Thrombolysis In Myocardial Infarction 48 Echocardiographic Study Investigators. Left atrial structure and function in atrial fibrillation: ENGAGE AF-TIMI 48. Eur Heart J. 2014 Jun 7;35(22):1457-65. doi: 10.1093/eurheartj/eht500. Epub 2013 Dec 2.
Giugliano RP, Ruff CT, Braunwald E, Murphy SA, Wiviott SD, Halperin JL, Waldo AL, Ezekowitz MD, Weitz JI, Spinar J, Ruzyllo W, Ruda M, Koretsune Y, Betcher J, Shi M, Grip LT, Patel SP, Patel I, Hanyok JJ, Mercuri M, Antman EM; ENGAGE AF-TIMI 48 Investigators. Edoxaban versus warfarin in patients with atrial fibrillation. N Engl J Med. 2013 Nov 28;369(22):2093-104. doi: 10.1056/NEJMoa1310907. Epub 2013 Nov 19.
Salazar DE, Mendell J, Kastrissios H, Green M, Carrothers TJ, Song S, Patel I, Bocanegra TS, Antman EM, Giugliano RP, Kunitada S, Dornseif B, Shi M, Tachibana M, Zhou S, Rohatagi S. Modelling and simulation of edoxaban exposure and response relationships in patients with atrial fibrillation. Thromb Haemost. 2012 May;107(5):925-36. doi: 10.1160/TH11-08-0566. Epub 2012 Mar 8.
Ruff CT, Giugliano RP, Antman EM, Crugnale SE, Bocanegra T, Mercuri M, Hanyok J, Patel I, Shi M, Salazar D, McCabe CH, Braunwald E. Evaluation of the novel factor Xa inhibitor edoxaban compared with warfarin in patients with atrial fibrillation: design and rationale for the Effective aNticoaGulation with factor xA next GEneration in Atrial Fibrillation-Thrombolysis In Myocardial Infarction study 48 (ENGAGE AF-TIMI 48). Am Heart J. 2010 Oct;160(4):635-41. doi: 10.1016/j.ahj.2010.06.042.
Other Identifiers
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DU176b-C-U301
Identifier Type: -
Identifier Source: org_study_id
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