The Association of Warfarin Dosage and Plasma Enantiomer Concentration With the Gene Polymorphisms of CYP and VKOR
NCT ID: NCT00247702
Last Updated: 2005-11-02
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
NA
120 participants
INTERVENTIONAL
2005-07-31
2006-06-30
Brief Summary
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The cytochrome P450 CYP2C9 is a liver enzyme required for the oxidative metabolism of warfarin. The vitamin K epoxide redutase (VKOR) is a liver enzyme associated with the reuse of the oxidative hydroquinone form of vitamin K. The VKOR enzyme is the target of warfarin. Recent studies revealed both genes may determine the pharmacodynamic of warfarin anticogualation. To date, there are more than thirteen identified polymorphism at CYP2C9 gene. Majority of those variant polymorphisms may decrease the warfarin requirement. The VKOR complex subunit 1 (VKORC1) is a newly identified gene. Some polymorphisms also were reported.
As we know, the Chinese patients need a lower dosage of warfarin in comparison with the Caucasian patients. We are interested in finding the genetic causes of Taiwneses Chinese patients. In our study we will first identify the polymorphism patterns of these two genes in normal population. Then, we will try to find the association between these polymorphism and patient warfarin requirement. Our pharmacogenetics study will be valuable for prevention of bleeding complication of warfarin treatment in Chinese population.
Detailed Description
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Conditions
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Keywords
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Study Design
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RANDOMIZED
SINGLE_GROUP
TREATMENT
NONE
Interventions
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warfarin
Eligibility Criteria
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Inclusion Criteria
* Stable INR value during recent three months
Exclusion Criteria
* liver and renal dysfunction
* alcohol abuse
* BMI\<18kg/m2
* coadministered medicine that can affect pharmacokinetics or pharmacodynamics of warfarin
18 Years
80 Years
ALL
No
Sponsors
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National Taiwan University Hospital
OTHER
Principal Investigators
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Tasy Wei, Doctor
Role: STUDY_CHAIR
National Taiwan Univerisity Hospital
Locations
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National Taiwan University Hospital
Taipei, , Taiwan
Countries
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Central Contacts
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Facility Contacts
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Tsay Wei, Doctor
Role: primary
Other Identifiers
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940609
Identifier Type: -
Identifier Source: org_study_id