Post-Authorisation Study on the Use of Bemfola® in Human Assisted Reproductive Technology

NCT ID: NCT02942849

Last Updated: 2020-02-05

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

1195 participants

Study Classification

OBSERVATIONAL

Study Start Date

2016-09-30

Study Completion Date

2018-12-31

Brief Summary

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Prospective, non-comparative, multi-centre, multi-country, observational post-authorization study, to correlate predictive factors with number of oocytes in relation to the gonadotropin dose administered using a new r-hFSH product (Bemfola®) for ovarian stimulation and GnRH-antagonists for pituitary suppression

Detailed Description

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This will be a prospective, non-comparative, multi-centre, multi-country, observational post-authorization study in Germany and Austria. The study will evaluate the use of follitropin alfa (Bemfola®) in controlled ovarian stimulation for IVF/ICSI.

About 30 ART centres will be involved in the study. Upon site initiation, each investigator site will enrol the subjects who meet the inclusion criteria.

As this is an observational study, there will be no additional treatment or diagnostic procedures performed on subjects other than those of the investigators' local routine clinical practice. The decision to start ART treatment and to use Bemfola® in controlled ovarian hyperstimulation (COH) following a GnRH antagonist protocol will be made independently by the investigators as per the ART centre's protocol, preceding patient enrollment for this study.

Conditions

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Infertility

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Interventions

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r-hFSH

As per standard clinical practice

Intervention Type DRUG

Other Intervention Names

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Bemfola

Eligibility Criteria

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Inclusion Criteria

* Female subject justifying an IVF/ICSI treatment
* Age over 18 years (inclusive) at the time of the screening visit
* Signed informed patient consent
* Received only Bemfola® for ovarian stimulation
* Pituitary suppression with GnRH-antagonists

Exclusion Criteria

* Hypersensitivity to the active substance follitropin alfa, FSH or to any of the excipients
* Tumours of the hypothalamus or pituitary gland
* Ovarian enlargement or ovarian cyst not due to polycystic ovarian syndrome
* Gynaecological haemorrhages of unknown aetiology
* Ovarian, uterine or mammary carcinoma
Minimum Eligible Age

18 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

No

Sponsors

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Finox AG

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Jan-Steffen Krüssel, MD

Role: PRINCIPAL_INVESTIGATOR

Leiter universitäres interdisziplinäres Kinderwunschzentrum Düsseldorf (UniKiD)

Locations

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Team Kinderwunsch Oldenburg

Oldenburg, Lower Saxony, Germany

Site Status

Countries

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Germany

Other Identifiers

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FIN-BEM-2016-04

Identifier Type: -

Identifier Source: org_study_id

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