Evolutive Potential of Embryos Obtained From Oocytes After Luteal Phase Ovarian Stimulation
NCT ID: NCT01645241
Last Updated: 2014-10-27
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
15 participants
INTERVENTIONAL
2012-07-31
2013-12-31
Brief Summary
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Detailed Description
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Conditions
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Study Design
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NA
SINGLE_GROUP
TREATMENT
NONE
Study Groups
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Lutheal phase ovarian stimulation
Early luteal phase Controlled ovarian hyperstimulation: we will administer in the 13th-15th cycle day simultaneously 0.25 mg/day of ganirelix to induce luteolysis and FSHr (dose according to BMI and AFC )IU/day for controlled ovarian hyperstimulation until achieving criteria for hCG , to induce final oocyte maturation. Mature oocytes will be vitrified. After warming, oocytes will be inseminated by ICSI with the recipients partners semen sample . Recipient endometrium will be primed with estrogen and progesterone , and embryo transfer will be performed on the 3rd day 3 of embryo cleavage.
gonadotropins plus GnRH antagonists
ganirelix
Interventions
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gonadotropins plus GnRH antagonists
ganirelix
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* regular cycles
* BMI \< 28
* signed informed consent
Recipients:
* Infertile women eligible for oocytes donation
* BMI \< 35
* Signed informed consent form
Exclusion Criteria
Recipients:
* Women eligible for oocytes donation
* BMI \>35
* Uncontrolled Endocrine Pathology
18 Years
35 Years
FEMALE
Yes
Sponsors
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FUNDACION DEXEUS SALUT DE LA DONA
UNKNOWN
Ayudas Merck Serono de Investigación 2012
UNKNOWN
Fundacion Dexeus
OTHER
Principal Investigators
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Francisca Martínez, PhD
Role: PRINCIPAL_INVESTIGATOR
Fundación Dexeus Salut de la Dona
Locations
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Departamento de Obstetricia Ginecologia y Reproducción. Institut Universitari Dexeus
Barcelona, Barcelona, Spain
Countries
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References
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Sonmezer M, Turkcuoglu I, Coskun U, Oktay K. Random-start controlled ovarian hyperstimulation for emergency fertility preservation in letrozole cycles. Fertil Steril. 2011 May;95(6):2125.e9-11. doi: 10.1016/j.fertnstert.2011.01.030. Epub 2011 Feb 3.
von Wolff M, Thaler CJ, Frambach T, Zeeb C, Lawrenz B, Popovici RM, Strowitzki T. Ovarian stimulation to cryopreserve fertilized oocytes in cancer patients can be started in the luteal phase. Fertil Steril. 2009 Oct;92(4):1360-1365. doi: 10.1016/j.fertnstert.2008.08.011. Epub 2008 Oct 18.
Martinez F, Clua E, Devesa M, Rodriguez I, Arroyo G, Gonzalez C, Sole M, Tur R, Coroleu B, Barri PN. Comparison of starting ovarian stimulation on day 2 versus day 15 of the menstrual cycle in the same oocyte donor and pregnancy rates among the corresponding recipients of vitrified oocytes. Fertil Steril. 2014 Nov;102(5):1307-11. doi: 10.1016/j.fertnstert.2014.07.741. Epub 2014 Aug 22.
Related Links
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Related Info
Other Identifiers
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DEX005
Identifier Type: -
Identifier Source: org_study_id
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