Evolutive Potential of Embryos Obtained From Oocytes After Luteal Phase Ovarian Stimulation

NCT ID: NCT01645241

Last Updated: 2014-10-27

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

15 participants

Study Classification

INTERVENTIONAL

Study Start Date

2012-07-31

Study Completion Date

2013-12-31

Brief Summary

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The purpose of this study is to evaluate the clinical pregnancy rate per embryo transfer in oocytes recipients obtained after ovarian stimulation during the luteal phase of oocytes donors . This study will be performed in egg recipients and donors but this type of treatment is meant to be implemented in fertility preservation patients

Detailed Description

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Conditions

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INFERTILITY Fertility Preservation Ovulation Induction Vitrification Oocyte Donation

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Lutheal phase ovarian stimulation

Early luteal phase Controlled ovarian hyperstimulation: we will administer in the 13th-15th cycle day simultaneously 0.25 mg/day of ganirelix to induce luteolysis and FSHr (dose according to BMI and AFC )IU/day for controlled ovarian hyperstimulation until achieving criteria for hCG , to induce final oocyte maturation. Mature oocytes will be vitrified. After warming, oocytes will be inseminated by ICSI with the recipients partners semen sample . Recipient endometrium will be primed with estrogen and progesterone , and embryo transfer will be performed on the 3rd day 3 of embryo cleavage.

Group Type EXPERIMENTAL

gonadotropins plus GnRH antagonists

Intervention Type DRUG

ganirelix

Intervention Type DRUG

Interventions

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gonadotropins plus GnRH antagonists

Intervention Type DRUG

ganirelix

Intervention Type DRUG

Other Intervention Names

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Ovarian stimulation the investigators will administer in the 13th-15th cycle day simultaneously 0.25 mg/day of ganirelix

Eligibility Criteria

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Inclusion Criteria

* premenopausal women, 18-35 years old, FSH levels \< 10 mIU/ml; AFC\> 10
* regular cycles
* BMI \< 28
* signed informed consent

Recipients:

* Infertile women eligible for oocytes donation
* BMI \< 35
* Signed informed consent form

Exclusion Criteria

-Polycystic ovarian syndrome, gonadotropins allergy

Recipients:

* Women eligible for oocytes donation
* BMI \>35
* Uncontrolled Endocrine Pathology
Minimum Eligible Age

18 Years

Maximum Eligible Age

35 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

Yes

Sponsors

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FUNDACION DEXEUS SALUT DE LA DONA

UNKNOWN

Sponsor Role collaborator

Ayudas Merck Serono de Investigación 2012

UNKNOWN

Sponsor Role collaborator

Fundacion Dexeus

OTHER

Sponsor Role lead

Principal Investigators

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Francisca Martínez, PhD

Role: PRINCIPAL_INVESTIGATOR

Fundación Dexeus Salut de la Dona

Locations

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Departamento de Obstetricia Ginecologia y Reproducción. Institut Universitari Dexeus

Barcelona, Barcelona, Spain

Site Status

Countries

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Spain

References

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Sonmezer M, Turkcuoglu I, Coskun U, Oktay K. Random-start controlled ovarian hyperstimulation for emergency fertility preservation in letrozole cycles. Fertil Steril. 2011 May;95(6):2125.e9-11. doi: 10.1016/j.fertnstert.2011.01.030. Epub 2011 Feb 3.

Reference Type BACKGROUND
PMID: 21292255 (View on PubMed)

von Wolff M, Thaler CJ, Frambach T, Zeeb C, Lawrenz B, Popovici RM, Strowitzki T. Ovarian stimulation to cryopreserve fertilized oocytes in cancer patients can be started in the luteal phase. Fertil Steril. 2009 Oct;92(4):1360-1365. doi: 10.1016/j.fertnstert.2008.08.011. Epub 2008 Oct 18.

Reference Type BACKGROUND
PMID: 18930226 (View on PubMed)

Martinez F, Clua E, Devesa M, Rodriguez I, Arroyo G, Gonzalez C, Sole M, Tur R, Coroleu B, Barri PN. Comparison of starting ovarian stimulation on day 2 versus day 15 of the menstrual cycle in the same oocyte donor and pregnancy rates among the corresponding recipients of vitrified oocytes. Fertil Steril. 2014 Nov;102(5):1307-11. doi: 10.1016/j.fertnstert.2014.07.741. Epub 2014 Aug 22.

Reference Type DERIVED
PMID: 25154677 (View on PubMed)

Related Links

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Other Identifiers

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DEX005

Identifier Type: -

Identifier Source: org_study_id

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