Feasibility and Smokers' Reactions to DNA Feedback

NCT ID: NCT02922790

Last Updated: 2018-01-05

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

39 participants

Study Classification

INTERVENTIONAL

Study Start Date

2017-02-14

Study Completion Date

2017-07-24

Brief Summary

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The purpose of the study is to explore how feedback of cellular DNA (Deoxyribonucleic Acid) damage, as a marker of exposure to the genotoxic agents of tobacco smoke, promotes cessation.

Detailed Description

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The study aims to recruit 50 smokers who are not engaged in quitting. The study will involve two in-person visits. During visit 1, participants will complete a baseline survey and have their blood drawn. Approximately two weeks later, in visit 2, smokers will be randomized in a 1:2:2 ratio to one of three arms:

1. education about harms of smoking (control group);
2. same education plus information on DNA damage and biomarker feedback (biomarker arm) without visual of damage; or
3. same as arm 2 except accompanied with visuals of participants' normal and DNA damage cells. Participants in the this arm will be informed of their proportion of leucocytes showing DNA damage with pictures of their normal and damaged cells.

The goal of the analyses is to obtain effect size estimates (direction, confidence intervals) to inform if results align with hypotheses and obtain insights about reactions about the feedback (Aim 1). The study will collect feasibility data from baseline to three months (e.g., percentage who show up to the sessions, attrition).

Conditions

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Smoking

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

OTHER

Blinding Strategy

NONE

Study Groups

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Control

Subjects will review standard health information on the health consequences of smoking.

Subjects will have blood drawn but it will not be tested for DNA damage.

Group Type ACTIVE_COMPARATOR

standard health information

Intervention Type BEHAVIORAL

Subjects will review standard health information

Biomarker feedback

Subjects will review this standardized health information, plus receive information on DNA damage along with feedback of their DNA damage.

Subjects will have blood drawn and the feedback will be presented at Visit 2.

Group Type ACTIVE_COMPARATOR

standard health information plus info. on DNA damage

Intervention Type BEHAVIORAL

Subjects will review standard health information and information on DNA damage

Biomarker feedback plus

Subjects will review this standardized health information, information on DNA damage along with feedback of their DNA damage, and will also will see images of their own cells with and without DNA damage.

Subjects will have blood drawn and the feedback and images will be presented at Visit 2.

Group Type ACTIVE_COMPARATOR

Subjects will review standard health information and information on DNA damage, plus pictures of their DNA damage

Intervention Type BEHAVIORAL

Subjects will review standard health information and information on DNA damage, as well as review pictures of their cells' DNA damage

Interventions

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standard health information

Subjects will review standard health information

Intervention Type BEHAVIORAL

standard health information plus info. on DNA damage

Subjects will review standard health information and information on DNA damage

Intervention Type BEHAVIORAL

Subjects will review standard health information and information on DNA damage, plus pictures of their DNA damage

Subjects will review standard health information and information on DNA damage, as well as review pictures of their cells' DNA damage

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

* ages 18+
* smoke \> 5 cig/day during the last week
* be open to biomarker feedback
* not actively trying to quit

Exclusion Criteria

* smoker carbon monoxide level(CO \< 10 ppm)
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Duke Cancer Institute

OTHER

Sponsor Role collaborator

Duke University

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Isaac Lipkus, PhD

Role: PRINCIPAL_INVESTIGATOR

Duke University School of Nursing

Locations

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Duke University Medical Center

Durham, North Carolina, United States

Site Status

Countries

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United States

Other Identifiers

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Pro00075612

Identifier Type: -

Identifier Source: org_study_id

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