Impact of Neutrophil Activation in Acute Ischemic Stroke Patients Treated With Endovascular Therapy

NCT ID: NCT02900833

Last Updated: 2026-01-20

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

ACTIVE_NOT_RECRUITING

Total Enrollment

440 participants

Study Classification

OBSERVATIONAL

Study Start Date

2016-03-24

Study Completion Date

2026-08-31

Brief Summary

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Clinical and experimental data suggest that neutrophil activation and extravasation are deleterious in acute ischemic stroke (AIS) involving an increased risk of unfavorable outcome and hemorrhagic transformation (HT). However, clinical trials targeting neutrophil recruitment in AIS patients were negative. Recently, an experimental study has shown that neutrophil activation and transmigration begin immediately after the occlusion. Inhibition of neutrophil recruitment several hours after the start of ischemia appears therefore too late to have a clinical relevance.

The objective is to study the time dependent impact of neutrophils in AIS and the predominant mediators in each time point to identify the appropriate therapeutic target and time window.

Detailed Description

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Conditions

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Acute Stroke

Study Design

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Observational Model Type

OTHER

Study Time Perspective

CROSS_SECTIONAL

Eligibility Criteria

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Inclusion Criteria

* age \>= 18 years old
* acute ischemic stroke secondary to a large vessel occlusion.
* Patients hospitalized for endovascular therapy.

Exclusion Criteria

* Pregnant or breast feeding patient
* patient under legal protection
* Patient opposition to participate in this study
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Fondation Ophtalmologique Adolphe de Rothschild

NETWORK

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Jean-Philippe DESILLES, MD

Role: PRINCIPAL_INVESTIGATOR

Fondation OPH A de Rothschild

Mikael MAZIGHI, MD, PhD

Role: STUDY_CHAIR

Fondation OPH A de Rothschild

Locations

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Fondation Ophtalmologique Adolphe de Rothschild

Paris, , France

Site Status

Countries

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France

References

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Boutelier A, Ollivier V, Mazighi M, Kyheng M, Labreuche J, Brikci-Nigassa N, Solo Nomenjanahary M, Delvoye F, Maier B, Paquet C, Ho-Tin-Noe B, Desilles JP. Acute astrocytic reaction is associated with 3-month functional outcome after stroke treated with endovascular therapy. Eur Stroke J. 2024 Dec;9(4):952-958. doi: 10.1177/23969873241256813. Epub 2024 Jun 6.

Reference Type DERIVED
PMID: 38845167 (View on PubMed)

Other Identifiers

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JDS_2015_46

Identifier Type: -

Identifier Source: org_study_id

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