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KERatoconus and Metalloproteinases InvesTigation

NCT ID: NCT02891655

Last Updated: 2020-12-10

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

23 participants

Study Classification

OBSERVATIONAL

Study Start Date

2016-12-02

Study Completion Date

2020-11-26

Brief Summary

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Corneal stromal thinning observed in keratoconic eyes could result from an increased synthesis of MMP at the level of the anterior stroma and the corneal epithelium induced by an overexpression of the Extracellular Matrix Metalloproteinase Inducer (EMMPRIN) and Galectin-3 by epithelial cells. A differential expression of EMMPRIN, Galectin-3 and metalloproteinases (MMP) may be observed between the apex of the keratoconus and the peripheral cornea. Highlighting the implication of EMMPRIN and Galectin-3 could lead to the development of specific inhibitors to slow or to stop keratoconus evolution.

Detailed Description

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Conditions

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Keratoconus

Study Design

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Observational Model Type

OTHER

Study Time Perspective

CROSS_SECTIONAL

Study Groups

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surgery for keratoconus

immuno-histo-chemical analysis

Intervention Type OTHER

in vitro immuno-histo-chemical analysis of corneal epithelium

refractive surgery (control patients)

immuno-histo-chemical analysis

Intervention Type OTHER

in vitro immuno-histo-chemical analysis of corneal epithelium

Interventions

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immuno-histo-chemical analysis

in vitro immuno-histo-chemical analysis of corneal epithelium

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* age \> 18 years old
* Patient with keratoconus undergoing corneal collagen cross-linking (epithelium-off methods)
* Patient with keratoconus undergoing his first corneal graft for optical indication (control)

Exclusion Criteria

* Patient with keratoconus undergoing corneal graft for tectonic indication
* Patient undergoing corneal refractive surgery (refractive photokeratectomy) with a normal topography, a normal slit lamp examination and no previous ophthalmic condition (control)
* pregnant or breast feeding patient
* patient under judiciary protection
* patient opposition to participate in the study
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Fondation Ophtalmologique Adolphe de Rothschild

NETWORK

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Eric GABISON, MD, PhD

Role: PRINCIPAL_INVESTIGATOR

Fondation OPH A de Rothschild

Locations

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Fondation Opthalmologique A de Rothschild

Paris, , France

Site Status

Countries

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France

Other Identifiers

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EGN_2016_6

Identifier Type: -

Identifier Source: org_study_id