Characterization of Immunosuppressive Signing of Cervical Cancer

NCT ID: NCT02875990

Last Updated: 2016-08-23

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

50 participants

Study Classification

INTERVENTIONAL

Study Start Date

2016-09-30

Study Completion Date

2024-09-30

Brief Summary

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Infection with Human Papillomavirus high-risk Human (HR-HPV) is the main factor of risk of cancer of the cervix. Recent studies show that cancers linked to infection with HR-HPV are associated with immunosuppression and lack of T cell response Such mechanisms would promote progression to cancer and progression of it . Various factors such as an increase of regulatory T cells, the presence of myeloid cells and suppressor of defects in the signaling pathway Toll Like Receptor (TLR) may have a key role in these immunosuppression mechanisms. At this stage of knowledge, a better characterization of local and systemic immunosuppressive signing of cervical cancer is needed. The results should have a significant medical impact for the identification of new prognostic markers and new therapeutic targets for the treatment of patients with cervical cancer.

The aim of this research project is to define the signing of immunosuppressive cancer cervix and analyze the different mechanisms involved in this immunosuppression.

Detailed Description

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Conditions

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Cervical Cancer

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

DIAGNOSTIC

Blinding Strategy

NONE

Study Groups

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patients with invasive cervical cancer

Blood sample

Group Type EXPERIMENTAL

Blood sample

Intervention Type BIOLOGICAL

Interventions

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Blood sample

Intervention Type BIOLOGICAL

Eligibility Criteria

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Inclusion Criteria

* The women presenting for initial therapeutic management of cervical cancer
* Elderly patients over 18 years
* Patients beneficiary of a social security scheme
* Pregnant women can not participate in this study
* Women known to be HIV positive will not participate in this study

Exclusion Criteria

* Patients with a recurrence of a treaty cervical cancer
* Patients with a history of pelvic radiotherapy
* Patients unable to receive informed about the progress and objectives of the study
* Patients not receiving a social security scheme
* Patients who have not signed informed consent
* Immunocompromised patients and pregnant women
Minimum Eligible Age

18 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

No

Sponsors

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Assistance Publique Hopitaux De Marseille

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Assistance Publique Hôpitaux de Marseille

Marseille, , France

Site Status

Countries

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France

Central Contacts

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Xavier CARCOPINO, PU-PH

Role: CONTACT

Urielle DESALBRES, Director

Role: CONTACT

04.91.38.27.47

Facility Contacts

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Xavier CARCOPINO, PU-PH

Role: primary

Urielle DESALBRES, Director

Role: backup

04.91.38.27.47

Other Identifiers

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2015-A00699-40

Identifier Type: REGISTRY

Identifier Source: secondary_id

2014-03

Identifier Type: -

Identifier Source: org_study_id

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