The Relationship Between Adipokines, Obesity and Insulin Resistance in Women With Polycystic Ovarian Syndrome

NCT ID: NCT02869750

Last Updated: 2018-10-02

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

300 participants

Study Classification

OBSERVATIONAL

Study Start Date

2016-11-30

Study Completion Date

2018-09-30

Brief Summary

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To evaluate possible clinical effects of adipokines , ( ghrelin, resistin and adiponectin), in obese and non-obese patients with polycystic ovary syndrome (PCOS).

Detailed Description

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Seventy selected PCOS patients will be recruited for this study, and will be divided into two groups based on their body mass index (BMI): 35 obese (BMI≥ 25 kg/m2, group A), 35 non-obese (BMI\<25 kg/m2, group B). In addition, 35 healthy non-obese women (BMI\<25 kg/m2) will bw enrolled as the control (group C). Serum levels of FSH (follicle stimulating hormone), LH (luteinizing hormone), T(testosterone), glucose, insulin, adiponectin, resistin and resistin will bw detected, and compared the differences of them among three groups

Conditions

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Polycystic Ovarian Syndrome

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Obese PCOS

PCOS patients with BMI more than 25 kg/m2

No interventions assigned to this group

Lean PCOS

PCOS patients with BMI less than 25 kg/m2

No interventions assigned to this group

PCOS with normal HOMA2-1R

PCOS without Insuline resistance

No interventions assigned to this group

PCOS with elevated HOMA2-IR

PCOS with Insuline resistance

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Females with PCOS in child bearing age who presented at reproductive and endocrinology clinics at Ain Shams University Maternity Hospital

Exclusion Criteria

* Known androgen secreting tumor.
* PCO on ovarian stimulation medications
* PCO with any other medical illness.
Minimum Eligible Age

18 Years

Maximum Eligible Age

40 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

Yes

Sponsors

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Ain Shams University

OTHER

Sponsor Role lead

Responsible Party

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Ahmed Mohamed El Kotb Abdel Fattah

Lecturer in obstertics and gynecology, Ain Shams University Hospital

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Ahmed Kotb

Cairo, Cairo Governorate, Egypt

Site Status

Countries

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Egypt

Other Identifiers

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ADIPCOS

Identifier Type: -

Identifier Source: org_study_id

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