Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
2500 participants
OBSERVATIONAL
2016-07-31
2036-07-31
Brief Summary
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Detailed Description
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Participation includes a blood draw, a mouth swab, and allowing researchers to look at your health information yearly for the next 5 years. Optional procedures include providing a urine and/or stool sample and taking part in the study for a longer time frame.
Conditions
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Study Design
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COHORT
PROSPECTIVE
Study Groups
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Those with trisomy 21
People aged 6 months to 89 years old who have some form of trisomy 21.
No interventions assigned to this group
Controls
People aged 6 months to 89 years old who do not have trisomy 21. These persons can be related to someone with some form of trisomy 21 but do not have to be related.
No interventions assigned to this group
Eligibility Criteria
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Inclusion Criteria
1. has Down syndrome (any type)
2. does not have Down syndrome
Exclusion Criteria
2. Wards of the state
6 Months
89 Years
ALL
Yes
Sponsors
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Linda Crnic Institute for Down Syndrome
UNKNOWN
National Center for Advancing Translational Sciences (NCATS)
NIH
GLOBAL Down Syndrome Foundation
UNKNOWN
Anna and John J. Sie Foundation
UNKNOWN
University of Colorado, Denver
OTHER
Responsible Party
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Principal Investigators
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Joaquin Espinosa, PhD
Role: PRINCIPAL_INVESTIGATOR
Linda Crnic Institute for Down Syndrome at the University of Colorado Denver
Locations
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Linda Crnic Institute for Down Syndrome at the University of Colorado Denver
Denver, Colorado, United States
Countries
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Central Contacts
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References
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Waugh KA, Araya P, Pandey A, Jordan KR, Smith KP, Granrath RE, Khanal S, Butcher ET, Estrada BE, Rachubinski AL, McWilliams JA, Minter R, Dimasi T, Colvin KL, Baturin D, Pham AT, Galbraith MD, Bartsch KW, Yeager ME, Porter CC, Sullivan KD, Hsieh EW, Espinosa JM. Mass Cytometry Reveals Global Immune Remodeling with Multi-lineage Hypersensitivity to Type I Interferon in Down Syndrome. Cell Rep. 2019 Nov 12;29(7):1893-1908.e4. doi: 10.1016/j.celrep.2019.10.038.
Related Links
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The Human Trisome Project™
Other Identifiers
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15-2170
Identifier Type: -
Identifier Source: org_study_id
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