Exercise and Arterial Modulation in Youth

NCT ID: NCT02853747

Last Updated: 2023-09-25

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Total Enrollment

337 participants

Study Classification

OBSERVATIONAL

Study Start Date

2016-05-31

Study Completion Date

2018-05-31

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

The project is designed as a large scale, cross-sectional study. The aim of the study is to investigate the association of micro- and macrovascular function with physical fitness and body composition in primary school children.

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

The investigators will examine whether physical fitness, body composition and blood pressure differently affect large and small arteries in young children. Furthermore, the investigators will examine whether pulmonary dysfunction is associated with vascular disorders and if subcutaneous advanced glycation endproducts (AGE's) mediate some of the vascular alterations observed.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Cardiovascular Disease Childhood Obesity Hypertension Endothelial Dysfunction

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Observational Model Type

COHORT

Study Time Perspective

CROSS_SECTIONAL

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Physical Activity, 20-meter shuttle run

cross-sectional physical activity assessment and medical screeening

Intervention Type BEHAVIORAL

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* primary school children aged 6-8 years who can participate in physical education lessons with written consent from their parents.

Exclusion Criteria

* children with a medical certificate that prohibits physical exercise with no consent from their parents.
Minimum Eligible Age

6 Years

Maximum Eligible Age

8 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

Meet the organizations funding or collaborating on the study and learn about their roles.

University of Basel

OTHER

Sponsor Role lead

Responsible Party

Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.

Henner Hanssen

Prof.Dr.med. Henner Hanssen

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

Learn about the lead researchers overseeing the trial and their institutional affiliations.

Henner Hanssen, Prof. Dr. med.

Role: PRINCIPAL_INVESTIGATOR

University of Basel

Lukas Zahner, Prof. Dr.

Role: PRINCIPAL_INVESTIGATOR

University of Basel

Locations

Explore where the study is taking place and check the recruitment status at each participating site.

Bereich Sport- und Bewegungsmedizin, Abteilung Präventive Sportmedizin und Systemphysiologie

Basel, Canton of Basel-City, Switzerland

Site Status

Countries

Review the countries where the study has at least one active or historical site.

Switzerland

References

Explore related publications, articles, or registry entries linked to this study.

Imhof K, Zahner L, Schmidt-Trucksass A, Faude O, Hanssen H. Influence of physical fitness and activity behavior on retinal vessel diameters in primary schoolchildren. Scand J Med Sci Sports. 2016 Jul;26(7):731-8. doi: 10.1111/sms.12499. Epub 2015 Jun 24.

Reference Type BACKGROUND
PMID: 26105148 (View on PubMed)

Veijalainen A, Tompuri T, Haapala EA, Viitasalo A, Lintu N, Vaisto J, Laitinen T, Lindi V, Lakka TA. Associations of cardiorespiratory fitness, physical activity, and adiposity with arterial stiffness in children. Scand J Med Sci Sports. 2016 Aug;26(8):943-50. doi: 10.1111/sms.12523. Epub 2015 Jul 29.

Reference Type BACKGROUND
PMID: 26220100 (View on PubMed)

Steinmann M, Abbas C, Singer F, Casaulta C, Regamey N, Haffner D, Fischer DC, Simonetti GD. Arterial stiffness is increased in asthmatic children. Eur J Pediatr. 2015 Apr;174(4):519-23. doi: 10.1007/s00431-014-2423-2. Epub 2014 Sep 25.

Reference Type BACKGROUND
PMID: 25248341 (View on PubMed)

Hauser C, Lichtenstein E, Nebiker L, Streese L, Kochli S, Infanger D, Faude O, Hanssen H. Cardiorespiratory fitness and development of childhood cardiovascular risk: The EXAMIN YOUTH follow-up study. Front Physiol. 2023 Aug 23;14:1243434. doi: 10.3389/fphys.2023.1243434. eCollection 2023.

Reference Type DERIVED
PMID: 37680774 (View on PubMed)

Kochli S, Smith W, Lona G, Goikoetxea-Sotelo G, Breet Y, Botha-Le Roux S, Mokwatsi GG, Kruger R, Hanssen H. Obesity, blood pressure and retinal microvascular phenotype in a bi-ethnic cohort of young children. Atherosclerosis. 2022 Jun;350:51-57. doi: 10.1016/j.atherosclerosis.2022.04.018. Epub 2022 Apr 21.

Reference Type DERIVED
PMID: 35490596 (View on PubMed)

Kochli S, Deiseroth A, Hauser C, Streese L, Schmidt-Trucksass A, Faude O, Hanssen H. Body Composition and Physical Fitness Affect Central Hemodynamics in Young Children. Front Pediatr. 2021 Oct 27;9:750398. doi: 10.3389/fped.2021.750398. eCollection 2021.

Reference Type DERIVED
PMID: 34778141 (View on PubMed)

Kochli S, Endes K, Grenacher J, Streese L, Lona G, Hauser C, Deiseroth A, Zahner L, Hanssen H. Socioeconomic Status and Parental Lifestyle Are Associated With Vascular Phenotype in Children. Front Public Health. 2021 Mar 26;9:610268. doi: 10.3389/fpubh.2021.610268. eCollection 2021.

Reference Type DERIVED
PMID: 33842418 (View on PubMed)

Kochli S, Endes K, Bartenstein T, Usemann J, Schmidt-Trucksass A, Frey U, Zahner L, Hanssen H. Lung function, obesity and physical fitness in young children: The EXAMIN YOUTH study. Respir Med. 2019 Nov;159:105813. doi: 10.1016/j.rmed.2019.105813. Epub 2019 Nov 8.

Reference Type DERIVED
PMID: 31731085 (View on PubMed)

Kochli S, Endes K, Steiner R, Engler L, Infanger D, Schmidt-Trucksass A, Zahner L, Hanssen H. Obesity, High Blood Pressure, and Physical Activity Determine Vascular Phenotype in Young Children. Hypertension. 2019 Jan;73(1):153-161. doi: 10.1161/HYPERTENSIONAHA.118.11872.

Reference Type DERIVED
PMID: 30571553 (View on PubMed)

Other Identifiers

Review additional registry numbers or institutional identifiers associated with this trial.

EKNZ258/12

Identifier Type: -

Identifier Source: org_study_id

More Related Trials

Additional clinical trials that may be relevant based on similarity analysis.

Sportcheck Follow-Up
NCT03085498 COMPLETED
Kettlebell-classroom Training
NCT06910085 COMPLETED NA