A Study of LGD-6972 in Patients With Type 2 Diabetes Mellitus

NCT ID: NCT02851849

Last Updated: 2018-01-12

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: PHASE2
• Total Enrollment: 148 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2016-09-30
• Study Completion Date: 2017-06-30

Brief Summary

The purpose of this study is to evaluate the change from baseline in hemoglobin A1c (HbA1c) during 12 weeks of treatment with 3 dose levels of LGD-6972 compared to placebo in subjects with Type 2 Diabetes Mellitus (T2DM)

Detailed Description

This will be a 12-week, randomized, double-blind, placebo-controlled, 4-arm, parallel group, multi-center study to evaluate the safety and efficacy of LGD-6972 in subjects with T2DM inadequately controlled on metformin monotherapy (a stable [≥12 weeks], daily dose of ≥1000mg at randomization). Subjects with T2DM will be treated with one of 3 dose levels of LGD-6972 (5 mg, 10 mg, or 15 mg) or placebo once daily (QD) for 12 weeks. Randomization will be stratified by HbAlc ≤8.5% or >8.5% at the Placebo Lead-in Visit.

Qualified subjects who require adjustment or stabilization of their metformin dose will participate in a run-in period of up to 12 additional weeks prior to randomization. Subjects will have the option to participate in an oral glucose tolerance test (OGTT) at baseline and end of treatment for assessment of exploratory endpoints.

Conditions

Type 2 Diabetes Mellitus

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: TREATMENT
• Blinding Strategy: DOUBLE

Study Groups

LGD-6972-5 mg

5 mg LGD-6972 QD

Group Type: ACTIVE_COMPARATOR

LGD-6972-5 mg

Intervention Type: DRUG

5 mg LGD-6972 QD

LGD-6972-10 mg

10 mg LGD-6972 QD

Group Type: ACTIVE_COMPARATOR

LGD-6972-10 mg

Intervention Type: DRUG

10 mg LGD-6972 QD

LGD-6972-15 mg

15 mg LGD-6972 QD

Group Type: ACTIVE_COMPARATOR

LGD-6972-15 mg

Intervention Type: DRUG

15 mg LGD-6972 QD

Placebo

Placebo QD

Group Type: PLACEBO_COMPARATOR

Placebo

Intervention Type: OTHER

Placebo QD

Interventions

LGD-6972-5 mg

5 mg LGD-6972 QD

Intervention Type: DRUG

LGD-6972-10 mg

10 mg LGD-6972 QD

Intervention Type: DRUG

LGD-6972-15 mg

15 mg LGD-6972 QD

Intervention Type: DRUG

Placebo

Placebo QD

Intervention Type: OTHER

Other Intervention Names

LGD-6972 sodium salt capsules; LGD-6972 sodium salt capsules; LGD-6972 sodium salt capsules

Eligibility Criteria

Inclusion Criteria

1. Female subjects must be surgically sterile (hysterectomy or bilateral oophorectomy or bilateral tubal ligation), or naturally post-menopausal for at least 12 months and with a follicle stimulating hormone (FSH) level in the post-menopausal range (if not taking hormone replacement therapy)

2. Male subjects must either have a vasectomy or agree that they and any female partners will use 2 acceptable forms of contraception, one of which must be a condom, until 30 days after the last dose of study drug. Other acceptable forms of contraception include hormonal contraceptives that have been at stable dose for 12 weeks prior to randomization, intrauterine device, Depo-Provera®, Norplant® System Implants, bilateral tubal ligation, bilateral oophorectomy, hysterectomy, and contraceptive sponge, foam, or jelly. Also, male subjects must not donate sperm during the study and for 30 days after the last dose of study drug

3. Willing and able to provide written informed consent

4. Diagnosis of T2DM according to American Diabetes Association criteria

5. Currently on stable metformin or metformin extended-release therapy (unchanged dose [minimum daily dose of 1000 mg] for ≥12 weeks prior to screening)

6. Subjects must have an HbA1c value of ≥7.0% to ≤10.5%

7. Subjects must have a fasting plasma glucose of ≤260 mg/dL

8. Subjects must have a body mass index (BMI) between 25 kg/m2 and 40 kg/m2, inclusive, and must weigh more than 45 kg

Exclusion Criteria

1. History of type 1 diabetes mellitus or history of diabetic ketoacidosis or persistent hypoglycemia or hypoglycemia unawareness

2. Women of childbearing potential, lactating, or has a positive pregnancy test

3. History or presence of alcoholism or drug abuse within 2 years prior to screening

4. Unwilling to comply with study restrictions, including restrictions on strenuous exercise

5. Presence of any of the following conditions: renal impairment (defined as history or estimated glomerular filtration rate at screening of <45 mL/min using the Modification of Diet in Renal Disease equation), diabetic proliferative retinopathy, severely symptomatic diabetic neuropathy requiring treatment, diabetic gastroparesis, active liver disease (other than asymptomatic nonalcoholic fatty liver disease), cirrhosis, symptomatic gall bladder disease, or pancreatitis

6. Serum triglyceride level > 400 mg/dL at screening

7. Liver transaminase levels (AST or ALT) >150% ULN, total bilirubin >2 ULN, or creatine kinase (CK) levels > 3 × ULN at screening

8. History or evidence of clinically significant cardiovascular, pulmonary, renal, endocrine (other than T2DM), hepatic, neurologic, psychiatric, immunologic, hematologic, gastrointestinal, or metabolic disease or surgical intervention (eg, bariatric surgery) or allergic conditions (including drug allergies, but excluding untreated, asymptomatic, seasonal allergies at time of dosing)

9. Myocardial infarction, unstable angina, arterial revascularization, stroke, symptomatic peripheral artery disease, deep vein thrombosis, New York Heart Association Functional Class III or IV heart failure, or transient ischemic attack within 6 months prior to screening

10. History of malignant hypertension or a recent history of uncontrolled high blood pressure or at screening has a seated systolic blood pressure >160 mmHg and/or diastolic blood pressure >100 mmHg after at least a 5 minute rest. Blood pressure is determined as the mean of triplicate measurements collected at 2- minute intervals after the subject has been sitting quietly for at least 5 minutes. Therapy for hypertension (beta blockers excluded) that has been stable for at least 8 weeks prior to screening is permitted

11. Arm size in excess of the maximum limit of the largest cuff provided with the study blood pressure monitor

12. History of malignancy (except adequately treated basal or squamous cell skin cancer or cervical carcinoma in situ) within 5 years prior to screening

13. History or evidence of QT prolongation or clinically significant QT prolongation (QTcF >450 msec) at screening, or other significant ECG findings at screening that may place the subject at increased risk by participating in the study

14. Treatment with any type of insulin (injected or inhaled) for > 6 consecutive days within 6 months prior to screening or any insulin therapy within 12 weeks prior to screening

15. Treated with peroxisome proliferator-activated receptor-gamma agonists (thiazolidinediones [TZDs]), incretin therapy (GLP-1 agonists). or amylin mimetics within 12 weeks prior to screening

16. Taking any of the following prohibited medications

• Antidepressants, antipsychotics, anti-epileptics, hormone replacement therapies (estrogen, progestin), testosterone therapies, and thyroid replacement medications that are not at a stable dose for at least 12 weeks prior to screening
• Lipid-modifying medications and anti-hypertensive medications that have not been at a stable dose for at least 8 weeks prior to the Screening Visit (excluding bile acid sequestrants, ezetimibe, and beta blockers, which are prohibited
• Over-the-counter herbal medications and supplement (aside from once daily multivitamins)

17. Treatment with systemic corticosteroids, which must be discontinued at least 4 weeks prior to screening. Note: Inhaled, intraarticular, intranasal and topical corticosteroids are permitted

18. Currently treated with weight-loss medications. These must be discontinued ≥12 weeks prior to screening

19. History or evidence of intravenous illicit drug use, active hepatitis B virus (HBV), hepatitis C virus (HCV), and/or human immunodeficiency virus (HIV) infection

20. Known hypersensitivity or idiosyncratic reaction to glucagon receptor (GCGR) antagonists or LGD-6972

21. Participation in another interventional clinical trial within 30 days prior to dosing or treatment with an investigational product with 14 days or 5 half-lives of the Screening Visit (whichever is longer)

22. Donated ≥ 450 mL of blood within 56 days of screening or has donated blood products within 30 days of screening

23. Inability to comply with study procedures or to adhere to study-required restrictions

• Minimum Eligible Age: 21 Years
• Maximum Eligible Age: 70 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Ligand Pharmaceuticals

INDUSTRY

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Keith Marschke, Ph.D.

Role: STUDY_DIRECTOR

Ligand Pharmaceuticals

Locations

Tuscumbia, Alabama, United States

Chandler, Arizona, United States

Surprise, Arizona, United States

Huntington Park, California, United States

Los Angeles, California, United States

Montclair, California, United States

North Hollywood, California, United States

San Diego, California, United States

Denver, Colorado, United States

Brooksville, Florida, United States

Miami, Florida, United States

Orlando, Florida, United States

Tampa, Florida, United States

Chicago, Illinois, United States

Las Vegas, Nevada, United States

Albuquerque, New Mexico, United States

Hopewell Junction, New York, United States

Durham, North Carolina, United States

Greensboro, North Carolina, United States

Franklin, Ohio, United States

Munroe Falls, Ohio, United States

Summerville, South Carolina, United States

Carrollton, Texas, United States

Dallas, Texas, United States

Houston, Texas, United States

Houston, Texas, United States

Houston, Texas, United States

Katy, Texas, United States

Manassas, Virginia, United States

Countries

United States

References

Pettus JH, D'Alessio D, Frias JP, Vajda EG, Pipkin JD, Rosenstock J, Williamson G, Zangmeister MA, Zhi L, Marschke KB. Efficacy and Safety of the Glucagon Receptor Antagonist RVT-1502 in Type 2 Diabetes Uncontrolled on Metformin Monotherapy: A 12-Week Dose-Ranging Study. Diabetes Care. 2020 Jan;43(1):161-168. doi: 10.2337/dc19-1328. Epub 2019 Nov 6.

Reference Type: DERIVED

PMID: 31694861 (View on PubMed)

Other Identifiers

L6972-04

Identifier Type: -

Identifier Source: org_study_id