Placebo Controlled Dose-Response Study of Rivoglitazone in Type 2 Diabetes

NCT ID: NCT00575471

Last Updated: 2009-03-02

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE2

Total Enrollment

250 participants

Study Classification

INTERVENTIONAL

Study Start Date

2007-07-31

Study Completion Date

2008-03-31

Brief Summary

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The purpose of this study is to assess the efficacy response of rivoglitazone HCl on the change in HbA1c after 12 weeks of treatment in patients with type 2 diabetes.

Detailed Description

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Conditions

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Type 2 Diabetes

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

QUADRUPLE

Participants Caregivers Investigators Outcome Assessors

Study Groups

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1

rivoglitazone HCl 0.5 mg tablets once daily for 12 weeks

Group Type EXPERIMENTAL

Rivoglitazone HCl

Intervention Type DRUG

0.5 mg tablets once daily for 12 weeks

2

rivoglitazone HCl 1 mg tablets once daily for 12 weeks

Group Type EXPERIMENTAL

rivoglitazone HCl

Intervention Type DRUG

1.0 mg tablets once daily for 12 weeks

3

rivoglitazone HCl 1.5 mg tablets once daily for 12 weeks

Group Type EXPERIMENTAL

rivoglitazone HCl

Intervention Type DRUG

1.5 mg tablets once daily for 12 weeks

4

Matching placebo tablets once daily for 12 weeks

Group Type PLACEBO_COMPARATOR

Placebo

Intervention Type DRUG

Matching placebo tablets once daily for 12 weeks

Interventions

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Rivoglitazone HCl

0.5 mg tablets once daily for 12 weeks

Intervention Type DRUG

rivoglitazone HCl

1.0 mg tablets once daily for 12 weeks

Intervention Type DRUG

rivoglitazone HCl

1.5 mg tablets once daily for 12 weeks

Intervention Type DRUG

Placebo

Matching placebo tablets once daily for 12 weeks

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* type 2 diabetes mellitus
* HbA1c \>6.5% and \<10%
* FPG \>126 mg/dL (7mmol/L) and \<270 mg/dL (15 mmol/L)

Exclusion Criteria

* history of type 1 diabetes
* history of ketoacidosis
* current insulin therapy
* C-peptide \<0.5ng/mL
* impaired hepatic function
* CHF or history of CHF (NYHA stage I - IV)
* uncontrolled hypertension
Minimum Eligible Age

20 Years

Maximum Eligible Age

75 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Daiichi Sankyo Co., Ltd.

INDUSTRY

Sponsor Role lead

Responsible Party

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Daiichi Sankyo Co. Ltd.

Locations

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Fukuoka, , Japan

Site Status

Osaka, , Japan

Site Status

Tokyo, , Japan

Site Status

Countries

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Japan

Other Identifiers

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CS011-A-J204

Identifier Type: -

Identifier Source: org_study_id

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